ABSTRACT The use and interpretation of figurative expressions (e.g., irony, idiom, and metaphor) is an integral part of everyday human communication. Thus, the ability to comprehend figurative language underpins successful communication and social functioning. Despite this, there is an ongoing debate regarding the fundamental cognitive and neural processes that support figurative language comprehension. In addition, relatively little is known regarding the additional challenges that can be faced in many situations, for example, when communicating in one’s second language, or with partners from a different culture, or when integrating information across different modalities. The purpose of this special issue is to showcase some of the latest research in this area, utilizing state of the art methods to examine comprehension (e.g., eye-tracking and EEG) and investigating how certain factors, such as cultural and individual differences and multimodal stimuli affect the comprehension process.