Toxic workplace culture, characterized by negative behaviors such as poor communication, lack of trust, and unethical conduct, poses significant challenges to organizational effectiveness and employee well-being. Leadership plays a pivotal role in either perpetuating or mitigating these toxic environments. This article critically examines the role of leadership in addressing toxic workplace culture, focusing on effective interventions that leaders can implement to transform negative work environments into positive and productive spaces. The study highlights how different leadership styles, particularly transformational and ethical leadership, are instrumental in fostering a culture of accountability, open communication, and ethical behavior. It also explores the importance of leadership interventions such as establishing clear organizational values, implementing conflict resolution mechanisms, and promoting continuous learning and development. However, the study also acknowledges the challenges leaders face, including resistance to change, deeply entrenched toxic behaviors, and external pressures that may undermine efforts to create a positive work environment. The findings suggest that while leadership is crucial in mitigating toxicity, success depends on sustained commitment, adaptability, and the ability to navigate complex organizational dynamics. By prioritizing ethical leadership and fostering a culture of inclusion and respect, organizations can effectively combat toxic workplace culture and promote long-term organizational health and success. This research contributes to the broader understanding of the critical role of leadership in shaping workplace culture and provides practical insights for leaders seeking to address and prevent toxicity in their organizations.