Background: Respiratory tract infections (RTI) can cause severe morbidity and morbidity in HIV-uninfected patients with even intact full functioning immune system, and for the majority of HIV paglents, RTl are the first secondary infections which may infect even detect HIV-positivity in some of the cases. In this study attempt has been made to correlate the degree of damage to immune system of the HIV patients and different etiological agents of RTl. Naturally, in HIV-infected, Immuno-compromised patients the prevalence of routine bacteriological and fungal RTl would be more, this study is designed to know exact prevalence rate of RTl in HIV patients of this region. RTl has broad spectrum of fungal and bacterial etiology, when combined with HIV, this feature confuses the treating physician. Without knowledge of incidence of common etiological agents and their susceptibility/ pattern it is difficult for him to select the right drug for treatment.
 Aim: HIV Infection and Secondary Bacterial and Fungal Respiratory Tract Infections in Central Indian Patients, as well as a Heart Survey.
 Material and Method: Secondary infections of the upper and lower respiratory tract are highly common in HIV-positive patients, and the majority of them have a bacterial etiology. The respiratory tract infections of HIV-infected patients do not differ too much than HIV-uninfected patients, except in degree. This study was done on a total number of 200 sputum samples collected from ICTC and ART Center during the study period. 
 Results: The HIV-positive patients were the ones who had the highest polymicrobial isolation. PCP was not detected in our investigation, perhaps due to the nature of the sample, which was sputum. According to the findings of this study, Mycobacterium tuberculosis, Klebsiella pneumoniae, Candida albicans, and Pseudomonas aeruginosa are the most common opportunistic pathogens among HIV-positive people in the Central Indian regions investigated. Constant monitoring of infections in HIV positive patients is crucial for better management and to improve the quality of life of such patients, due to the changing pattern of infections based on the degree of immuno-suppression.
 Conclusion: Despite the risks of side effects, the provision of highly active antiretroviral therapy in underdeveloped countries like ours should be supported, especially since these life-saving drugs are still unavailable to the vast majority of patients who require them. Even though there are certain side effects, HIV patients are advised to continue taking HAART. However, in order to manage the morbidity associated with HAART, appropriate clinical follow-up is also essential, and all of these factors may help them live longer.
 Keywords: Respiratory tract infections, Immuno-compromised patients, Human Immunodeficiency Virus, AIDS and HAART