Common Usage Research Articles

Differentially used codons among essential genes in bacteria identified by machine learning-based analysis.

Codon usage bias (CUB), the uneven usage of synonymous codons encoding the same amino acid, differs among genes within and across bacteria genomes. CUB is known to be influenced by gene expression and accordingly, CUB differs between the high-expression and low-expression genes in several bacteria. In this article, we have extended codon usage study considering gene essentiality as a feature. Using machine learning (ML) based approaches, we have analysed Relative Synonymous Codon Usage (RSCU) values between essential and non-essential genes in Escherichia coli and thirty-four other bacterial genomes whose gene essentiality features were available in public databases. We observed significant differences in codon usage patterns between essential and non-essential genes for majority of the bacterial genomes and accordingly, ML based classifiers achieved high area under curve (AUC) scores, with a minimum score of 70.0 across twenty-eight organisms. Further, importance of the codons towards classifying genes found to differ among the codons in each genome. Arg codon CGT and Gly codon GGT were observed to be the most preferred codons among essential genes in Escherichia coli. Interestingly, some of the codons like CGT, ATA, GGT and GGG observed to be contributing consistently towards classifying essential genes across thirty-five bacteria genomes studied. In other hand, codons TGY and CAY encoding amino acids Cys and His respectively were among the least contributing codons towards classification among all these bacteria. This study demonstrates the gene essentiality based differences in synonymous codon usage in bacteria genomes and presents a common codon usage pattern across bacteria.

Taxonomy for the assessment of the subjective experience of curly hair manageability.

This paper aims to develop and validate a taxonomy for the assessment of the subjective experience of curly hair manageability. It represents the latter of two iterative stages of a mixed-method design interdisciplinary project. The qualitative stage of the study incorporated thematic analysis of 14 interview transcripts generated using a video-ethnographic method (SEBE). A survey-based instrument assessing different elements of the construct of hair manageability designed during the first stage of this project was further developed following consultations with experts with extensive experience in hair research, product development, testing and trichology. The instrument was tested online with 506 female participants self-reporting natural curly hair, types 3A and higher according to the Andre Walker Curl Classification. The initial construct of four groups of hair goals received positive content validity from the experts. High scale reliability was achieved for the aesthetic, haptic and emotive goals' scales as well as for hair esteem (Cronbach's alpha >0.75). Curl type was the only personal hair attribute that was correlated with hair goals and perceptions. From the demographic and lifestyle data, only age was correlated with goals and willingness to try new products. Common hair practices and product usage were also correlated with hair curl and goals. The appropriateness of the instrument for measuring the strength of different hair goals and perceptions relevant to hair curvature degree and hair esteem has been validated. The instrument will support the development and testing of products better aligned with the manageability needs of very curly and textured hair. It was also confirmed that hair curvature is the most significant determinant of practices, and age of product attitudes.

Authentic assessment as relational pedagogy

ABSTRACT This article troubles a pervasive concept within higher education studies: authentic assessment. Authentic assessment is well-established within higher education, and yet its common usage leaves it limited in possibility. Often understood as a practice focused on tasks, where assessments represent a ‘reality’ beyond universities, authentic assessment praxis has missed engaging with wider literature exploring authenticity as an emergent quality connected with being and becoming. In this article, I first consider the utility of concepts in education, and then spotlight a change in how authentic assessment is being understood. I then move to explore how relational pedagogies might offer further insights into how assessment can be conceptualised and enacted, sketching shapes for thinking differently about authenticity in assessment. Extending the exciting conversation that is redirecting praxis, I argue that thinking with theory can help us think and enact assessment in a more meaningful mode, where assessment becomes a relational, ethical, act.

Euphemism in Saudi Slang: An Attitudinal Survey Study

This study explores some euphemistic expressions in common usage in the Kingdom of Saudi Arabia (KSA). It evaluates the degree to which Saudis are familiar with these expressions and how frequently they use them. The KSA covers a large area with a variety of dialects: thus, any socio-linguistic research which deals with slang should be meticulous. One enabling factor for this study is that Saudis are comparatively religious and avoidant of linguistic taboos, and consequently employ euphemisms often. Several research papers have tackled taboos in the KSA, but most of these have been contrastive to or comparative with British English or American English, while others have explored standard euphemistic expressions in classical Arabic. This study is unique in dealing with selective euphemisms used in Saudi slang through a survey devised to measure peoples' degree of knowledge as well as their usage of such expressions. After analyzing the results of the questionnaires, it is possible to derive several attitudinal results, the most important of which include the findings that present-day Saudis are generally well-acquainted with euphemism in their language and that they are inclined to employ it in everyday situations wherever appropriate. The population selected for this study is resident within the Al Riyadh region, or what can be called “Najid”. As the heart of the KSA, this region has Saudis from various regions and with a range of linguistic differences. However, it is recommended that similar studies be taken up in different parts of the KSA so as to pinpoint regional variations.

Exploratory mapping of tumor associated macrophage nanoparticle article abstracts using an eLDA topic modeling machine learning approach.

The role of macrophages in regulating the tumor microenvironment has spurned the exponential generation of nanoparticle targeting technologies. With the large amount of literature and the speed at which it is generated it is difficult to remain current with the most up-to-date literature. In this study we performed a topic modeling analysis of 854 abstracts of peer-reviewed literature for the most common usages of nanoparticle targeting of tumor associated macrophages (TAMs) in solid tumors. The data spans 20 years of literature, providing a broad perspective of the nanoparticle strategies. Our topic model found 6 distinct topics: Immune and TAMs, Nanoparticles, Imaging, Gene Delivery and Exosomes, Vaccines, and Multi-modal Therapies. We also found distinct nanoparticle usage, tumor types, and therapeutic trends across these topics. Moreover, we established that the topic model could be used to assign new papers into the existing topics, thereby creating a Living Review. This type of "birds-eye-view" analysis provides a useful assessment tool for exploring new and emerging themes within a large field.

Food uses, functional activities, and bioactive compounds of three Ecuadorian Vasconcellea fruits: Bibliometric analysis and review

Vasconcellea, the most abundant genus within the Caricaceae family, encompasses twenty-one out of the 35 species in the family, predominantly found in Peru, Ecuador, and Colombia, where they are utilized for both culinary and medicinal purposes. This study investigates the research trends, patents, and nutritional and functional potential of three native Ecuadorian species in the genus: Vasconcellea stipulata V.M. Badillo (toronche), Vasconcellea pubescens (V.M. Badillo) (chamburo), and their natural hybrid Vasconcellea x pentagona V.M. Badillo (babaco). Utilizing bibliometric analysis via a Scopus dataset of 117 documents and sixteen unique patents through Patentscope. Our findings reveal V. pubescens as the most studied species, followed by V. x pentagona and V. stipulata, with scientific production primarily originating from Chile, Brazil, Ecuador, and the United States. Patents focus on V. pubescens, particularly in cultivation and applications of protease and alcohol acyltransferase enzymes. Gastronomically, these species find common usage in jams, juices, and preserves and ritual beverages, with limited innovation. Food technology uses are mainly meat tenderization and beer clarification. Rich in nutrients, all three species offer health and dietary benefits, accompanied by diverse functional activities including anticancer, anti-inflammatory, antioxidant, antiparasitic, and antiseptic properties. Thirty-seven bioactive compounds, including organic acids, carotenoids, esters, alkaloids, phenolic compounds, amino acids, isothiocyanates, alcohols, tocopherols, and phytosterols, were reported across the species. This study underscores the global and local economic, industrial, and health-related significance of Vasconcellea species, while also indicating directions for further research and exploration to realize their full potential.

Self‐care rhetoric and institutional culpability: Theorizing the academy and intellectual labor

AbstractSelf‐care, a ubiquitous concept commonly touted as the solution to an array of modern‐day problems, implies unapologetic selfishness aimed at preserving mental, emotional, and physical health. The overtly individualistic framing in its most common usage—the centering of oneself for the sake of oneself—obscures power relations and structural/institutional inequalities that create the need for self‐care. To deal with difficult work or family lives, taking up a hobby or some kind of diversion offers an escape that feels good; self‐care serves as a kind of coping mechanism, but not a solution to a social problem. It also lets society, or more specifically, managers and administrators in organizations, off the hook because it places the onus on individuals to deal with challenges on their own rather than situating them as social problems. We critique shortcomings in self‐care rhetoric employed by organizations—and specifically university administrators—to their members, by extending Hochschild's economy of gratitude framework.

Machine learning-empowered sleep staging classification using multi-modality signals

The goal is to enhance an automated sleep staging system's performance by leveraging the diverse signals captured through multi-modal polysomnography recordings. Three modalities of PSG signals, namely electroencephalogram (EEG), electrooculogram (EOG), and electromyogram (EMG), were considered to obtain the optimal fusions of the PSG signals, where 63 features were extracted. These include frequency-based, time-based, statistical-based, entropy-based, and non-linear-based features. We adopted the ReliefF (ReF) feature selection algorithms to find the suitable parts for each signal and superposition of PSG signals. Twelve top features were selected while correlated with the extracted feature sets' sleep stages. The selected features were fed into the AdaBoost with Random Forest (ADB + RF) classifier to validate the chosen segments and classify the sleep stages. This study's experiments were investigated by obtaining two testing schemes: epoch-wise testing and subject-wise testing. The suggested research was conducted using three publicly available datasets: ISRUC-Sleep subgroup1 (ISRUC-SG1), sleep-EDF(S-EDF), Physio bank CAP sleep database (PB-CAPSDB), and S-EDF-78 respectively. This work demonstrated that the proposed fusion strategy overestimates the common individual usage of PSG signals.

Fear of Missing Out and Problematic Usage of Smartphones Concerning Adolescents

The development of technology and increase of common usage of mobile phone in recent years has caused the desire of the individual to share their lives with other individuals and the desire to be aware of their lives, that is, the fear of missing out regarding developments. By considering that the fear of missing out (fomo) and problematic cell phone use will affect adolescents, current study aimed to analyze the fomo and problematic mobile phone use of adolescents with regard to various variables. In present research, descriptive research design was conducted. The data of current study were collected with the fomo scale and the problematic smartphone usage scale. It was carried out with 673 adolescents who have been studying at high school. The results revealed that the fomo differs significantly in adolescents in terms of gender and class level and it was concluded that problematic smartphone usage differs significantly with regard to father education level, gender and class level. Moreover, it has been concluded that problematic mobile phone use did not differ with regard to mother and father education level, age, high school type and family income level. Additionally, the results of current research revealed that the fomo and problematic smartphone usage are positively and significantly related with each other regarding adolescents.

Growth, Yield and Quality of Linseed under Replacement Series in Legume Intercropping System

Among the oil seeds crops grown during rabi season, linseed is next in importance to rapeseed and mustard in area as well as production. This crop is often grown on marginal and sub marginal land in rainfed conditions as pure and mixed or intercrop. It is one among minor crops which is of economic value because of its common usage in animal feed, oil extraction, etc. There are many factors responsible for lack of productivity of linseed including crop failure. Therefore increasing productivity and avoiding the risk associated with complete crop failure intercropping is the way forward. Hence, a field experiment was conducted at College Agronomy Farm, B. A. College of Agriculture, Anand Agricultural University, Anand during two consecutive rabi season of the year 2019-20 and 2020-21 in Randomized Block Design (RBD), consisting of ninth different intercropping systems viz.; T1: sole chickpea, T2: sole linseed, T3: sole fenugreek, T4: (chickpea + linseed 2:1), T5: (chickpea + linseed 3:1), T6: (chickpea + linseed 4:2), T7: (chickpea + fenugreek 2:1), T8: (chickpea + fenugreek 3:1) and T9: (chickpea + fenugreek 4:2) with four replication. The results showed that the plant height of linseed at harvest, number of branches per plant at 60 DAS (Days after sowing) and at harvest was found significantly higher under treatment T2 (sole linseed) during the both years as well as in pooled results. Furthermore treatment T2 (sole linseed) recorded significantly higher number of capsules/plant during the year 2019-20, 2020-21 and on pooled base analysis, respectively but being comparable with treatment T4 (chickpea + linseed 2:1) during both the years. Maximum seed yield of linseed was obtained under treatment T2 (sole linseed) during the individual years and on pooled base analysis, respectively. Among the intercropping treatments, higher seed yield of linseed was obtained in the treatment T4 (chickpea + linseed 2:1). While the highest straw yield and harvest index of linseed was obtained in treatment T2 (sole linseed) during the year 2019-2020, 2020-21 and in pooled results. Treatment T2 (sole linseed) gave the highest crude protein (%) and oil content (%) during the both years as well as pooled results.

Article of Over the Counter (OTC) Products for Relief of Gastrointestinal Problems

Gastrointestinal problems affect millions worldwide, ranging from mild discomfort to debilitating conditions. Over-the-counter (OTC) products provide convenient relief from symptoms such as indigestion, heartburn, diarrhea, and constipation. This project aims to analyze OTC products for gastrointestinal relief by examining their active ingredients, effectiveness, side effects, consumer satisfaction, and common usage patterns. The classification of OTC products based on intended use and mechanism of action is outlined, including antacids, proton pump inhibitors (PPIs), H2 blockers, anti-diarrheals, laxatives, and gas relief medications. Causes of gastrointestinal problems and the advantages and disadvantages of OTC products are discussed. The importance of responsible use and the potential for abuse or misuse of OTC gastrointestinal products are highlighted. Overall, this project underscores the significance of OTC products in managing gastrointestinal symptoms, while emphasizing the importance of informed decision-making and responsible usage.

Maximizing Aqueous Drug Encapsulation: Small Nanoparticles Formation Enabled by Glycopolymers Combining Glucose and Tyrosine.

Highly potent heterocyclic drugs are frequently poorly water soluble, leading to limited or abandoned further drug development. Nanoparticle technology offers a powerful delivery approach by enhancing the solubility and bioavailability of hydrophobic therapeutics. However, the common usage of organic solvents causes unwanted toxicity and process complexity, therefore limiting the scale-up of nanomedicine technology for clinical translation. Here, we show that an organic-solvent-free methodology for hydrophobic drug encapsulation can be obtained using polymers based on glucose and tyrosine. An aqueous solution based on a tyrosine-containing glycopolymer is able to dissolve solid dasatinib directly without adding an organic solvent, resulting in the formation of very small nanoparticles of around 10 nm loaded with up to 16 wt % of drug. This polymer is observed to function as both a drug solubilizer and a nanocarrier at the same time, offering a simple route for the delivery of insoluble drugs.

George Sclavunos (1869-1954): Anatomical Insights and His Contribution into the "Magenstrasse of Waldeyer".

The purpose of this article is to present a well-known physician and highlight his contribution into an essential, but neglected anatomical feature. George Sclavunos (1869-1954) was a 20th century Greek physician, whose scientific work was a significant milestone in global medical knowledge. In 1899 he became Professor of Anatomy and Head Director of the Department of Anatomy. In 1906 Sclavunos G. published the first volume of the three volume book "Human Anatomy" (1906-1926), which is characterized by its unparalleled illustrations. For more than a century it was the most important book of medical literature in Greece. In 1926 he became a Full Member of the Academy of Athens and was named Life Partner of the International Anatomical Society. His interests included Anatomy, Physiology, Histology, as well as Osteology and Syndesmology. In his book "Human Anatomy", he described for first time the "Sialine Groove of the Stomach", which was described by Waldeyer-Hartz almost at the same time as the "Magenstrasse", a German word that means "stomach road". It is a ribbon-like path that extends along the lesser curvature of the stomach from the gastric cardia to the antrum and releases the gastric content directly into the small intestine. Its importance is confirmed by its association not only with drug delivery, but also with anti-obesity surgical techniques. The old German term has come back into common medical usage in view of the commonly performed Magenstrasse and Mill procedure, a form of bariatric surgery. CONCLUSION: Sclavunos G. managed to observe an anatomical structure that has remained of great importance until today.

SafeNet: Towards mitigating replaceable unsafe Rust code via a recommendation‐based approach

AbstractRust is a system‐level programming language with advantages in memory safety. It ensures that any Rust programs without unsafe code should not incur undefined behaviours. However, unsafe code still plays an essential role in Rust to achieve low‐level control. Therefore, a major design pattern of Rust programs is interior unsafe, which wraps unsafe code as safe APIs and handles all undefined behaviours internally. Rust standard library already provides a rich set of safe APIs to facilitate Rust code development. Nevertheless, due to unfamiliarity with these APIs, developers may misuse unnecessary unsafe code and suffer memory‐safety risks. In this paper, we investigate an approach to mitigate replaceable unsafe code. We first analyse unsafe APIs of the Rust standard library and summarize their common usage patterns. Each pattern corresponds to one or several code samples in our knowledge base. Then, we develop an approach to automatically recognize the usage pattern and recommend corresponding code samples. Our approach leverages dataflow analysis to exclude impossible patterns and employs a BERT‐based machine learning model to find the most similar pattern among the rest. We have conducted evaluation experiments with 472 unsafe code snippets collected from GitHub projects and successfully recognized the pattern of 394 snippets. We hope our approach can assist developers in detecting unnecessary unsafe code and suggesting safe alternatives.

Reply to “Comment on Comparison of direct and indirect measures of transport efficiency in single particle inductively coupled plasma mass spectrometry” by H. Goenaga-Infante

This paper provides a rebuttal to the comments on our original research article entitled “Comparison of Direct and Indirect Measures of Transport Efficiency in Single Particle ICP-MS” recently published by Goenaga-Infante in Spectrochimica Acta Part B: Atomic Spectroscopy.The intent of our study is not to condemn the dynamic mass flow (DMF) method but rather to explore the use parameters under which it can and cannot be applied. As explained in the original paper, the goal of this study is to evaluate the ranges of use conditions under which measures of transport efficiency (TE) yield accurate and reproducible results for spICP-MS measurements of particle number concentration (PNC) and particle size (diameter, PS) of various gold nanoparticle (AuNP) suspensions. The evaluation was performed through a systematic comparison of three methods for the measurement of TE: the particle frequency (TEF), particle size (TES), and DMF methods using three types of spray chambers operated at cooled and ambient temperature conditions and employing different ICP-MS platforms. While we appreciate thorough critical and constructive comments on our paper, we strongly disagree that the conclusions and highlights are not supported by the content and findings about the features and benefits of the DMF method.The discussion of three additional independent studies in this field by other spICP-MS expert groups that have been published after the submission of our manuscript is included in this paper. While the DMF approach has been used in two interlaboratory comparisons for TE determination in spICP-MS measurements of PNC, only one laboratory, namely the laboratory led by Goenaga-Infante, provided results using the DMF method in both projects. A method cannot be considered validated if successful results have only been demonstrated within one laboratory.The paper by Goenaga-Infante claims that the main use of DMF, the assignment of a SI traceable PNC value to new commercial nanomaterials (NMs), has not been highlighted explicitly in our original paper. The advantages and disadvantages of the DMF, TES, and TEF methods to measure TE were presented throughout the manuscript and are clearly summarized in the conclusion. The assignment of PNC that is metrologically traceable to the SI implies that all known or suspected uncertainty components including bias are taken into account. Our research shows that under some use conditions, the biases inherent to the DMF method are not yet fully understood and cannot be accounted for. While Cuello-Nuñez et al. Journal of Analytical Atomic Spectrometry, 2020, DOI: https://doi.org/10.1039/c9ja00415g state that cooled conditions (2 °C) were used in their work, they do not define the level of bias that can be expected if different spray chamber temperatures are used, and they do not provide recommendations on the optimal use conditions that define the field of applicability of the DMF method. Furthermore, besides the use of a Scott-type spray chamber cooled to 2 °C, neither the composition material of the spray chamber nor the volume of the Scott-type spray chamber were specified. It is important to note that in our original research, fifteen of the nineteen experiments were conducted using a cooled spray chamber. Also, the four different ICP-MS platforms were used in the standard configuration and with additional spray chamber options encountered in common ICP-MS usage. The value of our work is that it extends the study of Cuello-Nuñez et al. to a wide variety of use conditions routinely encountered in spICP-MS analysis.

Numerical Analysis of a Steel Hollow Beam Subjected to Axial Compression and Oblique Loadings

Over the past few decades there has been a growing interest in designing a structural component which is capable of absorbing a large amount of energy during impact. This so-called energy absorbers have found common usage in many applications such as in aircraft, automotive, and road barriers. This paper presents the crush analysis of a hollow square beam subjected to axial compression and oblique loadings. Quasi-static and dynamic numerical analyses using ANSYS finite element analysis commercial package were carried out on the beam subjected to various angles of oblique loadings applied at the edge of the beam to simulate one of the actual load cases which might occur in the event of impact. The isotropic strain hardening rule and the Johnson-Cook material models (for high strain rates) were utilized for the quasi-static and dynamic crush analyses respectively. Validation of the numerical analysis were carried out and the results were in good agreement with the published results which confirms the accuracy of the simulation scheme. Parametric study was performed for the steel hollow tube to investigate the effect of beam wall thickness, load obliquity, and the impact velocity onto the specific energy absorption (SEA) and the initial peak load. Based on the quasi-static analysis, it has been observed that the peak load and SEA increases with the beam wall thickness but linearly reduced when the oblique angles of the applied loadings are increased. On the other hand, increasing in the impact velocity has resulted in the increase in both the SEA and peak load.

Knowledge as a capability to make decisions: Experiences with a virtual support context

AbstractHuman decision making is an act or process that is based on explicit or tacit knowledge, and can be supported in a limitless number of ways. Knowledge is a broad and delicate concept, rich in nuance, a concept that has been interpreted, understood, and categorized in different ways. Even if it may be true that “all knowing is personal knowing,” all knowledge is not inevitably personal knowledge. Organizations have a common capability to act (i.e., knowledge capacity or intellectual capital), the lack of which would inevitably prevent organizational action and would lead to unpredictability, disorder and chaos. Hence, the conversion of personal knowledge to organizational usage has become an important and justified stream of research. However, there are serious conceptual barriers to deriving organizational knowledge directly from personal knowledge. Although the term “conversion” is partly misleading, it is used here in the absence of a better alternative to describe a type of knowledge generation process in which one kind of knowledge is used to create another kind of knowledge. In this paper, we define knowledge as the individual or organizational capability to make decisions. We show that the ability to make decisions is determined not only by the personal dimension but also by the social and material dimensions; knowledge is a triangular model that combines these three worlds. In order to explore and manage the resource of knowledge more effectively in organizational contexts, the key question involves how to support and stimulate the deployment of personal knowledge for common usage in organizational decision making. The contributions of this paper are firstly the provision of a theoretical basis for a virtual support context, and secondly a description of an experience with a concrete virtual context that supports and stimulates the conversion of personal knowledge into strategic, organizational decisions. The support system developed here provides a set of virtual conditions that can be used to exercise organizational skills and capabilities for effective decision making.

A critical view on using "life not worth living" in the bioethics of assisted reproduction.

This paper critically engages with how life not worth living (LNWL) and cognate concepts are used in the field of beginning-of-life bioethics as the basis of arguments for morally requiring the application of preimplantation genetic diagnosis (PGD) and/or germline genome editing (GGE). It is argued that an objective conceptualization of LNWL is largely too unreliable in beginning-of-life cases for deriving decisive normative reasons that would constitute a moral duty on the part of intending parents. Subjective frameworks are found to be more suitable to determine LNWL, but they are not accessible in beginning-of-life cases because there is no subject yet. Conceptual and sociopolitical problems are additionally pointed out regarding the common usage of clear case exemplars. The paper concludes that a moral requirement for the usage of PGD and GGE cannot be derived from the conceptual base of LNWL, as strong reasons that can be reliably determined are required to limit reproductive freedom on moral grounds. Educated predictions on prospective well-being might still be useful regarding the determination of moral permissibility of PGD and/or GGE. It is suggested that due to the high significance of subjective experience in the normativity of beginning-of-life bioethics, the discipline is called to more actively realize the inclusion of people with disabilities. This regards for instance research design, citation practices, and language choices to increase the accessibility of societal debates on the reproductive ethics of genetic technologies.

Gesture-Based Interactions: Integrating Accelerometer and Gyroscope Sensors in the Use of Mobile Apps

This study investigates the feasibility and functionality of accelerometer and gyroscope sensors for gesture-based interactions in mobile app user experience. The core of this innovative approach lies in introducing a dynamic and intuitive user interaction model with the device sensors. The Android app developed for this purpose has been created for its use in controlled experiments. Methodologically, it was created as a stand-alone tool to both capture quantitative (time, automatically captured) and qualitative (behavior, collected with post-task questionnaires) variables. The app’s setting features a set of modules with two levels each (randomized presentation applied, minimizing potential learning effects), allowing users to interact with both sensor-based and traditional touch-based scenarios. Preliminary results with 22 participants reveal that tasks involving sensor-based interactions tend to take longer to complete when compared to the traditional ones. Remarkably, many participants rated sensor-based interactions as a better option than touch-based interactions, as seen in the post-task questionnaires. This apparent discrepancy between objective completion times and subjective user perceptions requires a future in-depth exploration of factors influencing user experiences, including potential learning curves, cognitive load, and task complexity. This study contributes to the evolving landscape of mobile app user experience, emphasizing the benefits of considering the integration of device sensors (and gesture-based interactions) in common mobile usage.

Audiological and Vestibular Measurements in Chronic Renal Failure Patients Receiving Hemodialysis Treatment.

The aim was to evaluate the changes in the audiovestibular system in adult patients with the diagnosis of chronic renal failure who were treated with hemodialysis. Thirty-five patients diagnosed with chronic renal failure and receiving hemodialysis treatment 3 days a week and 35 healthy individuals were tested with pure tone audiometry, video head impulse test, and post-head shake nystagmus test. Dizziness Handicap Inventory was applied to all participants. The Dizziness Handicap Inventory scores of the patient groups are higher than the control groups (P=.001). In the video head impulse test, there is no statistically significant difference between the patient and control groups in terms of gain asymmetry. 17.1% of the patients had both left and right lateral saccades (P=.03). A statistically significant difference was also found after the post-head shake test (P=.025). In the patient group, an inverse relationship between the presence of left anterior right posterior saccades and blood urea nitrogen-creatinine ratio and a direct relationship between the presence of right anterior left posterior saccades and creatinine elevation were determined. The presence of saccades in the video head impulse test increased significantly as the disease duration of hemodialysis patients increased. It was determined that the overt and covert saccades in the video head impulse test increased significantly as the creatinine increased and the duration of the disease increased in the patients with chronic renal failure. The common clinical usage of video head impulse test in monitoring the vestibular side effects of creatinine elevation and disease duration in chronic renal failure patients may be possible with future studies.