This brief presents an efficient binary common subexpression elimination (BCSE)-based approach for designing reconfigurable interpolation root-raised cosine (RRC) finite-impulse-response (FIR) filter, whose coefficients change during runtime for multistandard wireless communication system called software-defined radio (SDR). Reconfiguration can be done conveniently by storing the coded coefficients in the lookup tables (LUTs), and loading the required coefficient set over the interpolation filter. In the proposed method based on 4-bit BCSE algorithm, first the number of binary common subexpressions (BCSs) formed in the coefficients is reduced. Hence, multiplexers, shifters, and adders in the multiplier structure are reduced, which results in the improvement of operating frequency. The number of addition operations is further reduced using programmable adders and an efficient polyphase interpolation structure is implemented to reduce the hardware cost. The proposed design has 49.5% less area-delay product and 28.6% improved frequency of operation when compared to a 2-bit BCSE-based technique reported earlier when implemented on Xilinx field-programmable gate array (FPGA) device XC2VP4FF672-6. Similarly, the proposed design supports 93.14 MHz operating frequency, which is 59.2% and 74.2% greater when compared to 2-bit BCSE- and 3-bit BCSE-based approach when implemented on XC2V3000FF1152-4. The proposed structure also shows improved performance in terms of speed and area when compared to distributed arithmetic (DA)-based and multiply-accumulate (MAC)-based approaches.