AbstractHuman error is one of the largest contributing factors to unsafe operation and accidents in high‐speed train operation. As a well‐known second‐generation human reliability analysis (HRA) technique, the cognitive reliability and error analysis method (CREAM) has been introduced to address HRA problems in various fields. Nevertheless, current CREAM models are insufficient to deal with the HRA problem that need to consider the interdependencies between the Common Performance Conditions (CPCs) and determine the weights of these CPCs, simultaneously. Hence, the purpose of this paper is to develop a hybrid HRA model by integrating CREAM, the interval type‐2 fuzzy sets, and analytic network process (ANP) to overcome this drawback. Firstly, the interval type‐2 fuzzy sets are utilized to express the highly uncertain information of CPCs. Secondly, the ANP is incorporated into the CREAM to depict the interdependencies between the CPCs and determine their weights. Furthermore, human error probability (HEP) can be calculated based on the obtained weights. Finally, an illustrative example of the HRA problem in high‐speed train operation is proposed to demonstrate the application and validity of the proposed HRA model. The results indicate that experts prefer to express their preferences by fuzzy sets rather than crisp values, and the interdependences between the CPCs can be better depicted in the proposed model.