Common Form Research Articles

Oral health and oral-health-related quality of life in people with X-linked hypophosphatemia

BackgroundX-linked hypophosphatemia (XLH) is a type of vitamin D-resistant rickets. It is the most common form of it and is related with oral health problems. This study aimed to analyze the OHRQoL of people suffering from XLH and measure physical oral health to confirm or refute evidence of reduced oral health.MethodsThe German version of the Oral Health Impact Profile (OHIP-14G), was used to measure OHRQoL. All study participants underwent clinical examination, and oral health was scored using the Physical Oral Health Index (PhOX).ResultsA total of 26 people participated in the study, of whom five were male and 21 were female. The average participant age was 40.9 ± 12.8 years. The OHIP-14G score was 14.3 (± 12.1; 95% CI: 9.37. 19.16) points (range 0–44 points). The PhOX score was 77.1 (± 9.9; 95% CI: 73.10—81.13) points (range 61–95 points).ConclusionsThe results of this study confirm that oral health and OHRQoL are both reduced in the studied cohort of people affected by XLH. Particular attention should be paid to perfect oral hygiene in people with XLH, as the impaired enamel mineralisation increases the risk of caries and thus also the occurrence of apical infections.

Combining X-ray micro-CT and microscopy-based images of two lianas species to derive structural, mechanical and functional relationships

This paper presents a biomechanical study of stems of two liana species, Clematis vitalba and Vitis vinifera, investigates the mechanical performance of these two liana species and attempts to enhance the understanding of structure–function relationships. The investigation involved mechanical testing of whole plant stems, supplemented by X-ray micro-CT (X-ray computed tomography at micron voxel size) imaging and 2D microscopic images of stained cross sections of the plant stems, to derive structure–function relationships with potential for application in bioinspired composite materials. The micro-CT images were compared to the microscopic images of stained cross sections, in order to show benefits and potential drawbacks of the X-ray micro-CT method with respect to traditional methods. The high-resolution 3D imaging capacity of micro-CT is exploited to explain the structural functionality derived from the mechanical testing. A simple finite element model is developed based on the plant topology derived by the micro-CT images and proved accurate enough to model the plant’s mechanical behaviour and assess the influence of their structural differences. The two plants exhibit different to each other physical and mechanical properties (density, strength and stiffness) due to their common growth form. Anatomical cross-sectional observation and X-ray micro-CT provide complementary information. The first method allows the identification of the lignified parts, supposedly more resistant mechanically, of these structures, while the second one provides a full 3D model of the structure, admittedly less detailed but providing the spatial distribution of density contrasts supposed to be important in the mechanical properties of the plant. The proposed methodological approach opens new perspectives to better understand the mechanical behaviour of the complex structure of plants and to draw inspiration from it in structural engineering.

Tuberculous Meningitis Complicated Without Deep Sylvian Cerebral Infarction: About an Immunocompetent Patient with HIV-AIDS

Introduction: Neuromeningeal tuberculosis is the most common form of extra-pulmonary tuberculosis in developing countries. It is the most serious form of Mycobacterium tuberculosis infection. Vascular complications of tuberculous meningitis involve functional prognosis of patients. Observation: In our daily practice, we frequently encounter cases of cerebral infarction associated with neuromeningeal tuberculosis in the infectious etiological balance. We report the case of an HIV immunocompetent patient hospitalized for neuromeningeal tuberculosis complicated with ischemic stroke. It was a 39-year-old patient, right-handed, admitted to the Neurology department of University Hospital of Cocody in whom the diagnosis of neuromeningeal tuberculosis was retained. She received treatment for tuberculosis in emergency. On the seventh day of hospitalization, she suddenly presented with a massive motor deficit of the left hemibody. The MRI performed was compatible with meningoencephalitis associated with recent deep right Sylvan ischemia foci. The evolution was marked by partial recovery of the left hemiplegia, right retro-bulbar neuritis, and iatrogenic hepatic cytolysis. Comments: Tuberculous meningitis remains today one of the most serious neurological conditions involving the vital and functional prognosis of patients. Association of cerebral infarction and tuberculous meningitis is of variable occurrence. There are reported cases in which cerebral infarction is a complication of tuberculous meningitis. On the other hand, the discovery of tuberculous meningitis can be observed in the assessment of a cerebral infarction in young subjects. Tuberculous meningovascularitis remains a rare condition in immunocompetent patients for HIVAIDS. It results from arterial occlusion by thrombosing and obliterating endarteritis. It represents a medical emergency requiring starting anti-tuberculosis treatment. The evolution depends on the precocity of the diagnosis and the speed of treatment. Conclusion: The sudden appearance of a neurological deficit in à patient with tuberculous meningitis even under specific treatment should suggest an ischemic stroke, especially if the symptomatology respects an anatomo-functional vascular systematization.

Effects of brackish water irrigation and biochar application on fertility, enzyme activity, and winter wheat yield in coastal saline‐alkali soils

AbstractSoil salinization is a common form of land degradation in coastal regions. The Yellow River Delta is a typical coastal saline‐alkali soils distribution region, with saline‐alkali soils accounting for nearly half of the total area of the region. In view of the lack of fresh water in the region, the use of brackish water and biochar made from agricultural waste to improve coastal saline‐alkali soils has a good application prospect, but there are fewer studies on this at present. To explore water conservation, fertilization, and yield enhancement solutions appropriate for saline‐alkali soils in the Yellow River Delta region, this study focused on investigating the impact of biochar addition on the fertility, enzyme activity, and winter wheat yield in saline‐alkali soils under brackish water irrigation conditions. The research was conducted through outdoor potting experiments, utilizing a local moderately saline‐alkali soil as the subject of study. The study design established three different irrigation water mineralization levels (0, 2, and 4 g L−1) during the research. Two types of biochar, wheat straw biochar (WB) and corn straw biochar (CB) were used with four different applications (0, 5, 10, and 20 t ha−1). There were 21 treatments; each replicated three times. The research findings indicated that brackish water irrigation adversely affected soil fertility and soil alkaline phosphatase activity and soil sucrase activity but increased soil urease activity and soil peroxidase activity. In contrast, biochar application improved soil fertility and enzyme activities. The soil fertility and enzyme activities of K2Y10 treatment was higher than that of CK (fresh water, no biochar application) except for soil total nitrogen, which increased by 5.5%–71.2%. While brackish water irrigation decreased winter wheat yield. Biochar application increased winter wheat yield, with the K2Y10 treatment showing the highest yield under brackish water irrigation conditions, and increased by 17.7% compared to CK. In conclusion, the study recommends a combination of water‐saving measures, fertilizer cultivation, and yield increase strategies to improve saline‐alkali soils in the Yellow River Delta region effectively. Specifically, irrigating with 2 g L−1 brackish water and application 10 t ha−1 of CB demonstrated greater efficacy in addressing the challenges of saline‐alkali soils in the region.

Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews.

The objective of this study is to evaluate the effectiveness and safety of ozone therapy (OT) in the treatment of knee osteoarthritis (KOA), which is the most common form of the disease. We analysed systematic reviews (SRs) of randomised controlled trials (RCTs) using the "A MeaSurement Tool to Assess systematic Reviews" (AMSTAR2) instrument to evaluate their quality. We developed a narrative synthesis report with eight SRs (15 RCTs/3,685 patients) to summarise the findings. The AMSTAR2 analysis indicated that all reviews had critically low confidence ratings. Statistically significant effects in pain reduction using OT compared to placebo groups were reported in three SRs. OT was shown to be comparable to other therapies in one SR and not superior in the other five. Six SRs highlighted the need for additional RCTs with improved methodological quality to confirm the efficacy of OT for KOA. SRs found fewer consistent effects for improving joint function. Regarding safety, seven SRs reported a low prevalence of minor adverse events linked with OT. Finally, this umbrella review highlights the beneficial effects and safety of OT in the treatment of KOA, particularly in pain control. The low methodological quality of RCTs and SRs limits the possibility of drawing conclusions on the effectiveness of the procedure in comparison to other therapies. Ensure adequate compliance with guidelines such as Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and AMSTAR2 has the ability to improve the quality of SRs in this area.

Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy.

Nemaline myopathies are the most common form of congenital myopathies. Variants in ACTA1 (NEM3) comprise 15-25% of all nemaline myopathy cases. Patients harboring variants in ACTA1 present with a heterogeneous disease course characterized by stable or progressive muscle weakness and, in severe cases, respiratory failure and death. To date, no specific treatments are available. Since NEM3 is an actin-based thin filament disease, we tested the ability of tirasemtiv, a fast skeletal muscle troponin activator, to improve skeletal muscle function in a mouse model of NEM3, harboring the patient-based p.Asp286Gly variant in Acta1. Acute and long-term tirasemtiv treatment significantly increased muscle contractile capacity at submaximal stimulation frequencies in both fast-twitch extensor digitorum longus and gastrocnemius muscle, and intermediate-twitch diaphragm muscle in vitro and in vivo. Additionally, long-term tirasemtiv treatment in NEM3 mice resulted in a decreased respiratory rate with preserved minute volume, suggesting more efficient respiration. Altogether, our data support the therapeutic potential of fast skeletal muscle troponin activators in alleviating skeletal muscle weakness in a mouse model of NEM3 caused by the Acta1:p.Asp286Gly variant.

Epigenetics as a Key Factor in Prostate Cancer.

Nowadays, prostate cancer is one of the most common forms of malignant neoplasms in men all over the world. Against the background of increasing incidence, there is a high mortality rate from prostate cancer, which is associated with an inadequate treatment strategy. Such a high prevalence of prostate cancer requires the development of methods that can ensure early detection of the disease, improve the effectiveness of treatment, and predict the therapeutic effect. Under these circumstances, it becomes crucial to focus on the development of effective diagnostic and therapeutic approaches. Due to the development of molecular genetic methods, a large number of studies have been accumulated on the role of epigenetic regulation of gene activity in cancer development, since it is epigenetic changes that can be detected at the earliest stages of cancer development. The presence of epigenetic aberrations in tumor tissue and correlations with drug resistance suggest new therapeutic approaches. Detection of epigenetic alterations such as CpG island methylation, histone modification, and microRNAs as biomarkers will improve the diagnosis of the disease, and the use of these strategies as targets for therapy will allow for greater personalization of prostate cancer treatment.

Accuracy of MRI in predicting deep myometrial invasion in endometrial cancer and the influence of leiomyoma, adenomyosis and the microcystic elongated and fragmented tumour pattern.

The most common form of endometrial cancer is Type 1 endometrioid adenocarcinoma. Depth of myometrial invasion is the most important prognostic factor correlating with overall patient survival. The objective was to investigate how accurate magnetic resonance imaging (MRI) is in predicting the depth of myometrial invasion in preoperative assessment, and the influence of leiomyoma and/or adenomyosis, or microcystic, elongated and fragmented (MELF) pattern of invasion on MRI diagnostic performance. Retrospective audit of 235 endometrial cancer patients from the regional Gynaecology Oncology multidisciplinary meeting at Auckland City Hospital, between January 2020 and January 2021. Radiologist assigned stage was compared to histopathology. Presence of leiomyoma, adenomyosis andMELF pattern evaluated followed by analysis under a Biostatistician's supervision. Overall MRI diagnostic accuracy for depth of myometrial invasion was 86%. For deep myometrial invasion, MRI had a sensitivity of 72% and specificity 91%. Out of the misreported 32/235 cases, 16 demonstrated fibroids and/or adenomyosis leading to a sensitivity of 57% and specificity 93% for deep invasion, compared with 94% and 74% respectively in the population without, demonstrating statistical significance. Thirty seven cases with MELF pattern of invasion showed a sensitivity of 81% and specificity 80% for deep invasion, compared with 63% and 92% respectively in the group without, demonstrating no statistical significance. MRI assessment of the depth of myometrial invasion in endometrial cancer has high accuracy. In the presence of background uterine fibroids/adenomyosis, pre-operative MRI accuracy of evaluating deep invasion shows a statistically significant reduction.

Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma.

Brain tumors are a diverse collection of neoplasms affecting the brain with a high prevalence rate in people of all ages around the globe. In this pathological context, glioblastoma, a form of glioma that belongs to the IV-grade astrocytoma group, is the most common and most aggressive form of the primary brain tumors. Indeed, despite the best treatments available including surgery, radiotherapy or a pharmacological approach with Temozolomide, glioblastoma patients' mortality is still high, within a few months of diagnosis. Therefore, to increase the chances of these patients surviving, it is critical to keep finding novel treatment opportunities. In the past, efforts to treat glioblastoma have mostly concentrated on customized treatment plans that target specific mutations such as epidermal growth factor receptor (EGFR) mutations, Neurotrophic Tyrosine Receptor Kinase (NTRK) fusions, or multiple receptors using multi-kinase inhibitors like Sunitinib and Regorafenib, with varying degrees of success. Here, we focused on the receptor tyrosine kinase AXL that has been identified as a mediator for tumor progression and therapy resistance in various cancer types, including squamous cell tumors, small cell lung cancer, and breast cancer. Activated AXL leads to a significant increase in tumor proliferation, tumor cell migration, and angiogenesis in different in vitro and in vivo models of cancer since this receptor regulates interplay with apoptotic, angiogenic and inflammatory pathways. Based on these premises, in this review we mainly focused on the role of AXL in the course of glioblastoma, considering its primary biological mechanisms and as a possible target for the application of the most recent treatments.

Work and community tourism: reflections on capitalist realism

This theoretical essay aims to reflect on the concept of capitalist realism, by the author Mark Fisher, and its correlation with the context of work in Amazonian tourism, especially that carried out in conservation units (CU) by traditional communities. Fisher defines capitalist realism as a widespread belief in a defeatist way, which supports the idea that capitalism is the only viable economic and political system, with no alternatives even in the face of widespread dissatisfaction. In the context of Amazonian tourism, the proposal for community tourism (TC) stands out as an alternative to the mainstream, focusing on local development centered on the communities' endogenous resources. However, the essay argues that TC analysis often neglects working conditions and industrial relations. The question arises as to how it is possible to propose a sustainable alternative without considering workers and their interactions with natural resources. On a methodological level, this study is a theoretical essay, anchored in a bibliographical review with a critical perspective and qualitative nature. As a preliminary result, it points to the danger in hybrid forms of work organization in tourism, highlighting that, although they can be forged as anti-capitalist alternatives, they end up being co-opted by a logic of maximizing profits, harming the conservation of common resources and the well-being of workers. The hopelessness of alternatives preached by capitalist realism in the context of work encounters barriers in experiences aligned with the solidarity economy, shared management of common resources, cooperatives and collective forms of work/equal distribution of income. Although there are significant experiences in the counterflow of mainstream tourism, they are not capable of revolutionizing the horizon of Amazonian community tourism.

At the Edge of Space: the Archaeology of Boundaries within a Landscape for Young Convicts

AbstractWithin a landscape, boundaries are the physically or socially defined lines that mark the limits of spaces. They can appear static and binary, and therefore analytically restricted. Yet it is argued here that while space is often analyzed in archaeology to inform social, economic, or institutional interpretations of a landscape, the analysis of boundaries is a complimentary method that captures movement, control, and prohibition mechanisms. Analyzing boundaries is shown to reveal aspects of change – sometimes diachronic and sometimes ephemeral – and a malleability that is often linked to materiality. The examination of the early nineteenth-century historical boundaries of Point Puer, a juvenile convict prison (1834–49) located in lutruwita/Tasmania, Australia, is used as a case study to illustrate their common archaeological forms. It is reasoned that the analysis of boundaries contributes dynamic interpretations of historical landscapes by theorizing boundaries as spatial frameworks to examine social and experiential elements of space.

Retromer-dependent lysosomal stress in Parkinson's disease.

While causative mutations in complex disorders are rare, they can be used to extract a biological pathway whose pathogenicity can generalize to common forms of the disease. Here we begin by relying on the biological consequences of mutations in LRRK2 and VPS35, genetic causes of autosomal-dominant Parkinson's disease, to hypothesize that 'Retromer-dependent lysosomal stress' represents a pathway that can generalize to idiopathic Parkinson's disease. Next, we outline a series of studies that can test this hypothesis, including the development of biomarkers of pathway dysfunction. If validated, the hypothesis can suggest a unified mechanism of disease and might inform future diagnostic and therapeutic investigations. This article is part of a discussion meeting issue 'Understanding the endo-lysosomal network in neurodegeneration'.

Study on the Influence of Water Erosion on the Bearing Capacity and Function of the High Pile Foundation of the Wharf

High-pile foundation is a common form of deep foundation commonly used in ocean environments, such as docks and bridge sites. Aiming at the problem of bearing capacity of high pile foundations, this paper proposes the calculation of bearing capacity and the analysis of scour depth of high pile foundations under the action of scour based on the modified p-y curve. In this paper, three kinds of scour mechanisms—natural evolution scour, general scour, and local scour—are described; and the calculation methods of scour widely used at present are compared and analyzed. The solution of the vertical stress of soil around the pile under local scour is solved and applied to the β method to solve the lateral resistance of the pile under local scour. The local erosion is equivalent to the whole erosion, and the expression of the ultimate soil resistance before and after the equivalent is calculated, respectively, according to the principle that the ultimate soil resistance at a certain point above the equivalent pile end remains unchanged. The distance from the equivalent soil surface to the pile end can be obtained simultaneously, and then the equivalent erosion depth, p-y curve of sand at different depths, and high pile bearing capacity can be obtained. Finally, it is found that the bending moment of a single pile body varies along the pile body in the form of a parabola, and the maximum bending moment of the pile body is below the mud surface and increases with the increase in horizontal load. When the scouring depth is 30 m, the horizontal load is 25 KN, and the maximum bending moment of the pile body is about 150 N·m. The data with a relative error greater than 10% accounted for only 16.6% of the total data, and the error between the calculated value and the measured value was small. The formula can predict the erosion depth more accurately.

Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia.

Ischemic stroke is the most common form of stroke and the second most common cause of death and incapacity worldwide. Its pathogenesis and treatment have been the focus of considerable research. In traditional Chinese medicine, the root of Mongolian astragalus has been important in the treatment of stroke since ancient times. Astragalus polysaccharide (APS) is a key active ingredient of astragalus and offers therapeutic potential for conditions affecting the neurological system, the heart, cancer, and other disorders. However, it is not yet known how APS works to protect against ischemic stroke. Rats were subjected to middle cerebral artery occlusion (MCAO) to imitate localized cerebral ischemia. Each of four experimental groups (normal, sham, MCAO, and MCAO+APS) contained 12 adult male Sprague-Dawley (SD) rats selected randomly from a total of 48 rats. Following successful establishment of the model, rats in the MCAO+APS group received intraperitoneal injection of APS (50 mg/kg) once daily for 14 days, whereas all other groups received no APS. The Bederson nerve function score and the forelimb placement test were used to detect motor and sensory function defects, while Nissl staining was used to investigate pathological defects in the ventroposterior thalamic nucleus (VPN). Immunohistochemical staining and Western blot were used to evaluate the expression of Neurogenic locus notch homolog protein 1 (Notch1), hairy and enhancer of split 1 (Hes1), phospho-nuclear factor-κB p65 (p-NFκB p65), and nuclear factor-κB p65 (NFκB p65) proteins in the VPN on the ischemic side of MCAO rats. APS promoted the recovery of sensory and motor function, enhanced neuronal morphology, increased the number of neurons, and inhibited the expression of Notch1/NFκB signaling pathway proteins in the VPN of rats with cerebral ischemia. After cerebral ischemia, APS can alleviate symptoms of secondary damage to the VPN, which may be attributed to the suppression of the Notch1/NFκB pathway.

A novel saliva-based miRNA profile to diagnose and predict oral cancer

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD). The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n = 50), OPMD (n = 52), and controls (n = 60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p, miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was: area under curve (AUC): 0.954, sensitivity: 86%, specificity: 90%, positive predictive value (PPV): 87.8% and negative predictive value (NPV): 88.5% whereas between OC and OPMD was: AUC: 0.911, sensitivity: 90%, specificity: 82.7%, PPV: 74.2% and NPV: 89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC, revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples.

Gambaran Kasus Penganiayaan di Wilayah Kerja Polsek Langowan Periode 2021-2022

Abstract: Illness and death can occur not only as a result of abnormalities or disease, but also through accidents or criminal acts. One form of crime that is often encountered is persecution. Based on case data taken by the Central Statistics Agency (BPS) from reports submitted to the police, although over the past 5 years it has tended to decrease, the number of cases of persecution in Indonesia is quite large. Langowan is one of the areas in North Sulawesi where acts of abuse are often found. The purpose of this study is to describe cases of abuse in the Langowan Police Working Area for the 2021-2022 period. The research design used was a cross-sectional study. The research was carried out by collecting secondary data, namely reports of cases of abuse in the working area of ​​the Langowan Police for the 2021-2022 period with the aim of obtaining the prevalence of the existing sample. A total of 55 cases of abuse occurred in the working area of ​​the Langowan Police for the 2021-2022 period with the most cases of abuse occurring in July 2021 and January 2022 with a total of 6 cases each (10.91%). Gender was dominated by men, namely 52 cases (94.55%). The largest age range is 17-25 years which is late adolescence with a total of 24 cases (43.64%). The most common forms of maltreatment were moderate maltreatment in 50 cases (90.91%). The most common type of violence is blunt violence with a total of 34 cases (58,62%). Most of the injuries occurred on the head with a total of 38 cases (50%). In conclusion, the most abuse occurred in July 2021 and January 2022, dominated by male victims, most aged 17-25 years, the moderate form of abuse, the type of blunt violence, and the location of the injury on the head. Keywords: Persecution Abstract: Illness and death can occur not only as a result of abnormalities or disease, but also through accidents or criminal acts. One form of crimes that is often encountered is persecution. Langowan is one of the areas in North Sulawesi where acts of abuse are often found. This study aimed to describe cases of persecution in the working area of Polsek Langowan in years 2021-2022. This was a descriptive and retrospective study with a cross-sectional design using reports of cases of persecution in the working area of Polsek Langowan in years 2021-2022. The results obtained a total of 55 cases of persecution occurred in 2021-2022, and the highest percentages of cases were in July 2021 and January 2022, each of six cases (10.91%). Gender was dominated by men, namely 52 cases (94.55%). The largest age range is 17-25 years which was late adolescence with a total of 24 cases (43.64%). The most common form of maltreatment was moderate maltreatment in 50 cases (90.91%). The most common type of violence was blunt violence with a total of 34 cases (58,62%). Most of the injuries occurred on the head with a total of 38 cases (50%). In conclusion, the most persecution occurred in July 2021 and January 2022, dominated by male victims, aged 17-25 years, moderate form of persecution, blunt violence, and the location of injury on the head. Keywords: persecution; blunt trauma; victim Abstrak: Kesakitan dan kematian bisa terjadi bukan hanya akibat adanya kelainan atau penyakit, tetapi juga melalui kecelakaan maupun tindakan kejahatan. Salah satu bentuk kejahatan yang sering ditemui yaitu penganiayaan. Langowan merupakan salah satu daerah di Sulawesi Utara yang sering didapatkan adanya tindak penganiayaan. Penelitian ini bertujuan untuk mengetahui gambaran kasus penganiayaan di Wilayah Kerja Polsek Langowan Periode 2021-2022. Jenis penelitian ialah potong lintang dengan mengumpulkan data sekunder yaitu laporan kasus penganiayaan di wilayah kerja Polsek Langowan Periode 2021-2022. Hasil penelitian mendapatkan sebanyak 55 kasus penganiayaan di wilayah kerja Polsek Langowan periode 2021-2022, dengan kasus penganiayaan terbanyak terjadi pada bulan Juli 2021 dan Januari 2022 dengan total masing-masing enam kasus (10,91%). Jenis kelamin didominasi oleh laki-laki yaitu sebanyak 52 kasus (94,55%). Rentang usia terbanyak yaitu 17-25 tahun yang merupakan masa remaja akhir dengan total 24 kasus (43,64%). Bentuk penganiayaan terbanyak yaitu penganiayaan sedang sebanyak 50 kasus (90,91%). Jenis kekerasan terbanyak yaitu kekerasan tumpul dengan total 34 kasus (58,62%). Lokasi perlukaan terbanyak terjadi di bagian kepala dengan total 38 kasus (50%). Simpulan penelitian ini ialah penganiayaan paling banyak terjadi di bulan Juli 2021 dan Januari 2022, didominasi oleh korban laki-laki, usia 17-25 tahun, bentuk penganiayaan sedang, jenis kekerasan tumpul, dan lokasi perlukaan di bagian kepala. Kata kunci: penganiayaan; trauma tumpul; korban

The research progress and research trends in acute coronary syndrome nursing: A review of visual analysis based on the Web of Science database.

Acute coronary syndrome (ACS) is one of the most common and severe forms of cardiovascular disease and has attracted worldwide attention with increased morbidity and mortality in recent years. There are few review studies in the field of its care in the form of bibliometric studies. We searched the Web of Science Core Collection database for articles and reviews in the area of ACS nursing for visual mapping analysis. Our objectives are to explore the hot topics and frontiers of research in the field of ACS nursing and to identify collaborative relationships between countries, institutions, and authors. This study will provide researchers with intuitive reference data for future in-depth studies of ACSs.

Violence against women during pregnancy and its dimensions in COVID-19 pandemic: A systematic review and meta-analysis

ABSTRACT This systematic review and meta-analysis investigated the prevalence of violence against pregnant women during COVID-19 pandemic based on the available evidence. Medline, Scopus, Web of Science, and Google Scholar were searched. All published observational articles from December 2019 to December 2022 were assessed by two independent authors using the “violence, pregnancy, COVID-19” keywords. The quality appraisal of primary studies conducted using the Newcastle - Ottawa Quality Assessment Scale checklist and 10 eligible articles were included in this review. After reviewing the articles, the prevalence of violence among pregnant women during the COVID-19 pandemic was estimated to be 23% [95% confidence interval (CI) =18 to 29%] using the random effect model. Of them, 59% (95% CI = 13 to 105%) was attributed to verbal-behavioral violence, 30% (95% CI = 17 to 42%) emotional violence, 14% (95% CI = 8 to 20%) sexual violence, and 11% physical violence (95% CI = 6 to 17%). The results indicated that the violence prevalence among pregnant women was not different during and before the start of the COVID-19 pandemic. However, the behavioral-verbal, emotional, physical, and sexual violence were the most common forms of violence.

New Multitarget Rivastigmine-Indole Hybrids as Potential Drug Candidates for Alzheimer's Disease.

Alzheimer's disease (AD) is the most common form of dementia with no cure so far, probably due to the complexity of this multifactorial disease with diverse processes associated with its origin and progress. Several neuropathological hallmarks have been identified that encourage the search for new multitarget drugs. Therefore, following a multitarget approach, nine rivastigmine-indole (RIV-IND) hybrids (5a1-3, 5b1-3, 5c1-3) were designed, synthesized and evaluated for their multiple biological properties and free radical scavenging activity, as potential multitarget anti-AD drugs. The molecular docking studies of these hybrids on the active center of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) suggest their capacity to act as dual enzyme inhibitors with probable greater disease-modifying impact relative to AChE-selective FDA-approved drugs. Compounds 5a3 (IC50 = 10.9 µM) and 5c3 (IC50 = 26.8 µM) revealed higher AChE inhibition than the parent RIV drug. Radical scavenging assays demonstrated that all the hybrids containing a hydroxyl substituent in the IND moiety (5a2-3, 5b2-3, 5c2-3) have good antioxidant activity (EC50 7.8-20.7 µM). The most effective inhibitors of Aβ42 self-aggregation are 5a3, 5b3 and 5c3 (47.8-55.5%), and compounds 5b2 and 5c2 can prevent the toxicity induced by Aβ1-42 to cells. The in silico evaluation of the drug-likeness of the hybrids also showed that all the compounds seem to have potential oral availability. Overall, within this class of RIV-IND hybrids, 5a3 and 5c3 appear as lead compounds for anti-AD drug candidates, deserving further investigation.

CuFasterTucker: A Stochastic Optimization Strategy for Parallel Sparse FastTucker Decomposition on GPU Platform

The amount of scientific data is currently growing at an unprecedented pace, with tensors being a common form of data that display high-order, high-dimensional, and sparse features. While tensor-based analysis methods are effective, the vast increase in data size has made processing the original tensor infeasible. Tensor decomposition offers a solution by decomposing the tensor into multiple low-rank matrices or tensors that can be efficiently utilized by tensor-based analysis methods. One such algorithm is the Tucker decomposition, which decomposes an N -order tensor into N low-rank factor matrices and a low-rank core tensor. However, many Tucker decomposition techniques generate large intermediate variables and require significant computational resources, rendering them inadequate for processing high-order and high-dimensional tensors. This paper introduces FasterTucker decomposition, a novel approach to tensor decomposition that builds on the FastTucker decomposition, a variant of the Tucker decomposition. We propose an efficient parallel FasterTucker decomposition algorithm, called cuFasterTucker, designed to run on a GPU platform. Our algorithm has low storage and computational requirements and provides an effective solution for high-order and high-dimensional sparse tensor decomposition. Compared to state-of-the-art algorithms, our approach achieves a speedup of approximately 7 to 23 times.