Common Dental Diseases Research Articles

OPTIMIZATION AND IMPROVEMENT OF CARIES TREATMENT IN THE FIELD OF PERMANENT TEETH FISSURES IN CHILDREN

Dental caries is the most common dental disease in children. The problem of timely diagnosis, prevention and adequate treatment of this pathology occupies one of the leading places in pediatric therapeutic dentistry. However, before applying the sealant, the dentist faces the difficult task of assessing the condition of the fissure, diagnosing a possible latent carious lesion, and choosing adequate tactics for therapeutic and preventive measures. Fissure caries occupies the first place in the structure of carious lesions of the teeth. Based on this, the problem of prevention and treatment of fissure caries is extremely urgent. It has been established that fissure caries occurs immediately after teething. The high incidence of fissure caries is associated with the features of the anatomical structure of the fissures, the accumulation of food residues and the formation of aggressive dental plaque in the natural recesses of the tooth and a longer period of hypomineralization compared with smooth tooth surfaces. There is a direct relationship between the initial level of mineralization of the enamel of fissure teeth and the risk of fissure caries.

A 980 nm Diode Laser as an Adjunctive Therapy on the Healing of Apical Periodontitis Following Endodontic Retreatment: A Randomized Controlled Clinical Trial Study.

Introduction: Apical periodontitis is one of the common dental diseases. Microorganisms are the main reasons for these lesions; irrigations are used to remove them, but because of limited penetration, the rinsing agents may not always kill the microorganisms. Laser irradiation is effective in canal disinfection. The goal of this study was to compare the effect of calcium hydroxide (Ca(OH)2 ) and diode laser on the improvement of apical periodontitis following root canal retreatment (RCR). Methods: Twenty-four teeth of 19 patients with periapical lesions which needed RCR were divided into two groups (Ca(OH)2 and Ca(OH)2+laser irradiation [LI]). In the first session, after gutta-percha removal, cleaning, and shaping, Ca(OH)2 was used for 10 days. In the second session, in the Ca(OH)2+LI group, the irradiation utilizing a diode laser (using non-initiated 200-µm fiber, continuous wave (CW), power output of 1W) was done. The periapical radiographic healing was assessed before the retreatment and after 3-month and 6-month follow-ups by periapical index (PAI) Qrstavik. The quantitative data were analyzed (P<0.05). Results: The initial periapical lesion score was 3.75 and 3.88 in the Ca(OH)2 and Ca(OH)2+LI groups, respectively. In the Ca(OH)2 and Ca(OH)2+LI groups, 3 months after the RCR, the average periapical lesion score was 2.94 and 3.05, respectively. In the Ca(OH)2 and CA(OH)2+LI groups, 6 months after the RCR, the average periapical lesion score was 1.80 and 1.75, respectively. No significant differences were found at the 3 and 6 months between the experimental groups. Conclusion: The diode laser can reduce the periapical lesion, but there was no significant difference between CA(OH)2+LI and Ca(OH)2 at 3-month and 6-month follow-ups.

DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF GINGIVAL FLUID CYTOKINES IN THE DEVELOPMENT OF INFLAMMATORY PERIODONTAL DISEASES

Inflammatory periodontal diseases are one of the most common dental diseases in the world, along with dental caries. In the modern concept of the development of inflammatory periodontal diseases, one of the important roles is assigned to the body's immune response to the action of periodontal pathogenic microorganisms. In modern scientific literature, the concept of cytokine development of inflammatory periodontal diseases has been formed and substantiated. Evaluation of the cytokine profile of oral and gingival fluids allows us to determine the activity and severity of the disease. Well-founded immunological and molecular genetic mechanisms for the development of inflammatory periodontal diseases, associated with the influence of cytokines, make it possible to adjust the complex treatment of inflammatory periodontal diseases, determine the direction of personalized therapy for patients, determine the effectiveness of the treatment and the prognosis of the disease.

Water pollution with fluoride in the Republic of Moldova and its impact on oral health

Water quality, especially drinking water quality, is one of the most essential requirements for the survival of not only mankind but all terrestrial life on Earth. As a determining factor of health, the quality of drinking water must correspond to sanitary regulations, and the violation of the water protection regime results in pollution. Water pollution is one of the major threats to public health in the Republic of Moldova. According to data compiled by the Yale Center for Environmental Law and Policy, globally, the Republic of Moldova was placed 83rd out of 180 countries in terms of drinking water quality, the first place being occupied by the countries with the highest drinking water quality. The „age-standardized life-years lost per 100,000 people due to exposure to unsafe drinking water (Daily rate)” is a measure used to evaluate the quality of water. The Daly score for the Republic of Moldova in 2022 was 50.0. The Republic of Moldova is considered a biogeochemical zone with regard to some chemical elements in the environment, including the content of fluorine in groundwater, soil, and subsequently in food products. The analysis of water samples taken by the National Public Health Center of the Republic of Moldova demonstrated that in 90% of cases, water sources subjected to laboratory investigations for microbiological and chemical parameters (boron, fluorine, and nitrates) do not meet the requirements. The present study was a prospective, observational one, the main objective of which was to evaluate the epidemiological dental characteristics of children from the fluorosis-endemic area of the Republic of Moldova. The study targeted 520 12- and 15-year-old children from Fălești district, where the fluoride concentration in drinking water exceeds 16 times the permissible norm of 16.2 ppm/l. Thus, the prevalence of dental fluorosis in this locality (Dean index ≥1) was 98.7 for 12-year-old children and 100% for 15-year-old adolescents. The prevalence of dental caries was 51.2% with an intensity of 2.1 for 12-year-old children, and for 15-year-old children, the prevalence was 67.1% with an intensity of 3.5. Children’s age and severity of dental fluorosis were independent predictors of dental caries intensity. Thus, a positive correlation was established between the severity of dental fluorosis and the intensity of dental caries in both study groups and in all groups of teeth. The percentage of children with a COAD index (decayed, filled, or absent teeth) ≥1 was higher in those whose Dean index was ≥ 5 in the second molar compared to other groups of teeth. Conclusion. Dental fluorosis remains the most common dental disease in fluorosis-endemic areas, and the severity of fluorosis increases with increasing fluoride concentrations in drinking water. Contrary to the previously established opinion, tooth decay also develops in children from endemic areas of fluorosis, and its frequency and intensity are directly correlated with the concentration of fluoride in drinking water. The higher the concentration of fluoride, the higher the values of the prevalence indices and intensity of dental caries. Republic of Moldova performs suboptimally in the prevention of oral diseases in the pediatric population, and the implementation of dental disease prevention programs would have major implications for improving dental morbidity.

THE STUDY THE EFFECT OF COMPLEX TREATMENT OF PATIENTS WITH EARLY CLINICAL MANIFESTATIONS OF INCREASED TOOTH ABRASION ON THE QUALITY OF LIFE

To date, an increase in the number of dental erosions is one of the most common dental diseases. The most important factor in the correction of CAN is to compensate for the loss of hard tooth tissues. We propose a minimally invasive restoration technique for restoring dental defects with increased erosion, developed on the basis of experimental data studying morphostructural changes in hard tooth tissues. Combined treatment of cases of increased dental erosion resulted in a fourfold improvement in QOL due to dental health, according to the integral index.

A large case-control study indicates a breed-specific predisposition to feline tooth resorption

Tooth resorption (TR) is one of the most common dental diseases of cats. It is a painful condition leading to tooth loss. The etiology of TR remains unclear, but old age, breed, other oral and dental diseases, and environmental factors are suspected predisposing factors. In our study, we used part of the data from the extensive feline health online survey of 8115 Finnish cats. As TR is difficult to detect and as the feline health survey included diagnoses defined by both veterinarians and the owners, we limited our study to a subpopulation of cats diagnosed with oral or dental disease by a veterinarian and had dental examination or surgery under sedation (n=944). We utilized case-control study analysed by multivariable logistic regression to determine the risk factors and breed variation of feline TR. The 202 cats diagnosed with TR were defined as TR cases and the remaining 742 cats as controls. The frequency of veterinarian-diagnosed TR was 3.9% in the health survey data (316/8115) and 21% in the subpopulation (202/944). The risk of TR increased with age (14.7% in youngest and 25.3% in oldest age group). Our finding that TR was significantly associated with gingivitis or periodontitis in cats that had also calculus (OR: 2.49 and 3.70, respectively) suggests that inflammatory changes caused by calculus increase the risk of TR. We found that Cornish Rex, European, and Ragdoll are at higher risk for TR (OR: 2.44, 2.98 and 2.90, respectively). Exotic-Persians breed group had lower risk (OR: 0.28). TR was not observed in Turkish van or Devon Rex. The differences between breeds highlight a genetic contribution. In addition, female cats that had food available constantly had significantly less TR than female cats that had feeding times (OR: 0.44). The underlying reasons for this remain unexplained in our study.

Computed Tomographic Findings of Dental Disease and Secondary Diseases of the Head Area in Client-Owned Domestic Rabbits (Oryctolagus cuniculus): 90 Cases.

Domestic rabbits have teeth that grow throughout the animal's life and are prone to disease. Clinical signs of dental disease in domestic rabbits are non-specific, and, therefore, a definitive diagnosis usually requires additional methods. This study was carried out on a group of 105 domestic rabbits aged 3 to 9 years. In total, 90 domestic rabbits with dental disease visible on CT images and other secondary diseases of the head area qualified for this study. Malocclusion was found in 57 (63.3%). Retrograde elongation of the tooth apices in the mandible was present in 39 (43.3%), and it was present in the maxilla in 48 (53%). Clinical tooth crowns were overgrown in 39 (43%). Dental abscesses were present in 54 (63%). Secondary to the presence of a dental abscess, osteomyelitis was found in 43 (79% of the animals with a dental abscess). Dental inflammatory resorption was found in 36 (40%). Secondary to dental disease, nasal cavity inflammation was found in 18 (20%). Otitis media was present in six (6.7%). The most common dental disease found in this study's animals was malocclusion secondary to abnormal clinical crown abrasion and abnormal tooth growth. In domestic rabbits, osteomyelitis is a common complication of dental abscesses. Computed tomography is an invaluable diagnostic method in the diagnosis of dental disease and secondary diseases of the head area, such as inflammation of the nasal cavities or otitis media, in pet rabbits.

Dentistry in Ancient Egypt

Dentistry, dated in Ancient Egypt as an independent profession since the early 3rd millennium BC, was the first specialty recorded in a document in ancient Egypt, but nothing proves teeth interventions in mummies. The mouth and dental preservation was very important in rituals and theology because, as a source of exterior speech, it allowed man to express his spiritual feelings. The emphasis put on the mouth, lips, tongue, palate and teeth, was connected with the soul, the expression, and articulation of words. In the ‘Opening of the mouth’ ceremony, the dead jaws were freed to rebirth, give a voice and utter the words and names of power. Thus the white and healthy child Horus’ teeth allow to make up the undamaged mouth (PT 79 a) and five onions, their symbolic representation, were given the dead as a sacred offering. The emphasis put on the mouth, lips, tongue, palate and teeth, was connected with the soul, the expression, and articulation of words. As source of exterior speech, they allow man to express his spiritual feelings. In the Memphite theology the intellectual God Creator Ptah have generated the world pronouncing their names. Teeth and lips represent the magical verbal action and the tongue means speech, the _logos_. Dental problems were well known and some indications of doctor’s different diagnosis and treatments were found in medical papyri. The most common dental diseases were: attrition, frequent until pulp exposure, receding gums, caries and the destruction of enamel, chronic suppurative periodontitis that causes mobility, dental abscess and sepsis, loose teeth, ulcerative stomatitis, alveolar diseases and heavy deposits of calculus. Egyptian paleopathology and molecular biology provide new medical information and had revolutionized all aspects of dentistry, changing previous beliefs. However Egyptians were creative or witty and had devised many treatments for the various affections, both chirurgical and medicinal in nature, using different drugs. By studying a critical scrutiny of the development of dentistry profession in ancient times, it has been possible an exploration of dental problems, diseases and treatments and establishing guidelines and difficulties.

Порівняльна клінічна характеристика застосування цифрових і аналогових відбитків на якість непрямих реставрацій у пацієнтів із дефектами твердих тканин жувальних зубів у різні терміни спостереження

Introduction. Diseases of the hard tissues of the teeth are recognized as one of the most common dental diseases. These are mainly dental caries, congenital defects, fractures, fluorosis or acid erosion. Production of indirect restorations, which require taking impressions of the jaws, is one of the most common methods of restoring the hard tissues of the tooth when they are significantly destroyed. In today’s era of growing interest in digital dentistry, researchers are still undecided as to whether a digital impression provides the same accuracy as a conventional impression for making indirect restorations. Goal. To conduct a comparative characterization of the use of digital and analog impressions on the quality of indirect restorations in patients with defects of the hard tissues of chewing teeth at different follow-up periods. Research material and methods. The research involved 58 patients aged 25-60 years who applied to the Department of Stomatology of the P. L. Shupyk National Healthcare University of Ukraine for the purpose of orthopedic treatment of 79 defects of the hard tissues of the lateral teeth with destruction of 50-60% of their occlusal surface. In the course of orthopedic rehabilitation, patients were made indirect restorations - ceramic inlays using E. MAX Press material (Ivoclar Vivadent, Liechtenstein, Germany). The research group was further divided into 2 subgroups depending on the method of obtaining the impression. Subgroup A included patients who underwent digital scanning of a one-stage two-phase silicone impression, and subgroup B included patients who underwent impression removal using an intraoral digital impression system (TRIOS®, 3shape). The degree of destruction of the occlusal surface of chewing teeth and the choice of indirect restoration was carried out using the index of destruction of the occlusal surface of chewing teeth for I and II class according to Black (IROPZ). The clinical quality of indirect restorations was evaluated 1 week after the installation of the restoration and at long-term periods (12, 24, 36 months) using visual-instrumental control and according to the recommendations of the revised FDI criteria for the evaluation of direct and indirect dental restorations (2023). The presence of inflammatory changes in periodontal tissues was determined using the gingivitis index, the presence of dental plaque was determined using the OHI-S index (Green-Vermillion, 1964), the gingival sulcus bleeding index (SVI) was determined according to the Miihlemann and Son method before indirect restorations, during 1 week, 12 month and 24 month visits after cementation. Conclusion. Dental restorations made using digital impressions showed similar marginal discrepancy as restorations made using traditional impression methods (P&gt;0.05). Lateral masticatory restorations fabricated by intraoral scanning using CAD/ CAM technology have acceptable results in terms of periodontal tissue condition, color, contour, marginal adaptation, and occlusion. Although both direct and indirect digitization have been shown to be equally effective, digital impressions have shown advantages in patient acceptance of the procedure. They take less time for both the doctor and the patient and facilitate the digital workflow. No significant difference was found between conventional and digital displays in the accuracy of the 3D data sets. Key words: defects of hard dental tissues, indirect restorations, digital and traditional impression, inflammatory changes in periodontal tissues, marginal adaptation.

Anti-inflammatory and antibacterial properties of insulin leaves (Tithonia diversifolia) for Periodontitis

Introduction: Periodontal disease or disorders can arise from disruption of homeostasis in the periodontal tissue. Ninety percent of people worldwide suffer from periodontal disease, making it the most common dental disease. Periodontitis may increase the rate of mortality and morbidity significantly. Prevention strategies can be carried out with alternative materials. The use of Tithonia diversifolia or insulin leaves has been practiced folklorically by different ethnic groups without scientific evidence, especially for the treatment of conditions related with pain and inflammation. Methods: The search of literature is conducted through PubMed, Cochrane, the Web of Science, and Google Scholar using keywords for the role of insulin leaf extract (Tithonia diversifolia) as anti-inflammatory and antibacterial for periodontitis. Journal published at least five years ago is acquired. The journal covered the topics of various risk factors for Varicella. The criteria for this study are national and international accredited journals by Scopus and non-Scopus. Results: Of the 15 articles reviewed, it is known that there is a role for insulin leaf extract (Tithonia diversifolia) in the treatment and prevention of periodontitis. Conclusion: From the literature review article obtained, there are several roles of insulin leaf extract (Tithonia diversifolia) in the treatment and prevention of periodontitis with anti-inflammatory and antibacterial mechanisms. Using insulin leaves as mouthrinse can also improve oral health and reduce tooth decay.

Adolescent Toothbrushing and Its Association with Sociodemographic Factors-Time Trends from 1994 to 2018 in Twenty Countries.

Regular toothbrushing is the primary self-care method to prevent the most common dental diseases and is considered an important public health indicator. This retrospective observational study aimed to examine cross-national time trends in adolescent toothbrushing behaviour and its association with sociodemographic factors between 1994 and 2018. We studied data from 20 countries that conducted seven surveys of the Health Behaviour in School-aged Children (HBSC) study. Adolescents aged 11, 13 and 15 years responded to questions on their toothbrushing frequency, family affluence and structure. Altogether, reports of 691,559 students were analysed using descriptive statistics and binominal logistic regression. The findings showed an overall positive trend in the prevalence of more-than-once-a-day toothbrushing frequency during the entire study period mainly due to a noticeable increase from 1994 to 2010 (except Denmark and Sweden); this trend continued significantly thereafter in 12 of 20 countries. Across all countries, girls and adolescents from more affluent families were more likely to brush their teeth regularly. These relationships remained unchanged throughout the study period, whereas the age-related difference in toothbrushing prevalence decreased noticeably, and the negative relationship between toothbrushing and living in a non-intact family became evident. While the prevalence of regular toothbrushing among adolescents has increased in recent decades, it is still far behind the recommended level of twice-daily brushing for everyone across all countries. The promotion of toothbrushing needs to start at an early age, with a special focus on boys and adolescents from low-affluence and non-intact families.

The prevalence and risk factors of dental disease found in 100 miniature horses

IntroductionDental disease is a common condition affecting horses. Its prevalence and characteristics among most of the common breeds of horses and donkeys have been investigated and described in the literature, but information about the prevalence and etiology of dental disease of miniature horses is sparse.MethodsTo determine the prevalence and characteristics of dental disease of miniature horses, we performed oral and dental radiographic examinations on 100 miniature horses. The findings of these examinations were analyzed to determine the prevalence of dental disease and its correlation to age, sex, weight, body condition score, height at the withers, head length and head width. Older horses had a higher prevalence of dental disease, diastemata and crown elongations.ResultsThe most common dental diseases detected in this population were crown elongation, oral mucosal ulceration, diastemata, class 1 malocclusion and hypodontia. Horses with a high body condition score had an increased likelihood of having a class 1 malocclusion. Horses with wider heads had a higher prevalence of dental disease and class 1 malocclusions.ConclusionFrequent oral examinations, starting at an early age, should be prioritized as a part of miniature horse preventive health care to decrease morbidity and slow progression of dental disease.

The impact of Cortexin on cytokine levels in the treatment of moderate chronic generalized periodontitis in young and middle-aged people

Relevance. Chronic generalized periodontitis is one of the most common dental diseases in Russia and worldwide. Periodontitis causes changes in the immune system, cytokines, antioxidant protection, hemostasis and other systems, leading to periodontal microcirculatory and blood supply damage. Interleukins are regulatory molecules that play a part in specific immune reactions: inflammation, regeneration, and microcirculation. They are produced by immune system cells in response to an activating stimulus and regulate the strength and duration of immune and inflammatory reactions. Our study revealed an imbalance of pro- and anti-inflammatory cytokines in patients with moderate chronic generalized periodontitis of different ages.Material and Methods. The study involved 130 patients with moderate chronic generalized periodontitis aged 25 to 60. The control group consisted of 15 practically healthy individuals aged 18 to 24 years without acute and chronic periodontal diseases at the time of the study. The concentration of cytokines in blood serum and oral fluid (IL-1ß, IL-4, IL-8, IL-10) was evaluated in all patients before and after the standard comprehensive treatment and with the inclusion of Cortexin.Results. After the moderate chronic generalized periodontitis treatment, pro-inflammatory and anti-inflammatory cytokines in the blood decreased in the group of 25-44-year-olds. In standard treatment, IL-1ß level decreased by 30%, IL-4 – by two times, IL-8 – by 1.5 times, and IL-10 – by three times; but with Cortexin, IL-1ß became normal, IL-4 decreased by 3.5 times, IL-8 – by 2.5 times, IL-10 became normal. In the oral fluid of patients aged 25-44 years, IL-1ß decreased by 20% after the standard treatment, IL-4 decreased by six times, IL-8 decreased by two times, and the addition of Cortexin to the comprehensive therapy caused a 70% decrease, IL–4 reduced by ten times, IL-8 – by nine times, the concentration of IL-10 remained the same. IL-22 decreased by 1.5 and 2 times based on the treatment methods. The after-treatment assessment of changes in the interleukin content in blood serum in 45-60-year-old patients with chronic generalized periodontitis revealed the same levels of IL-4 after the standard treatment, a decrease of IL-1ß by 1.5 times, IL-8 - by 1.5 times; and the use of Cortexin in the treatment normalized the concentration of IL-4, led to a decrease in IL-1ß by two times, IL-8 - by three times. After the therapy, in the oral fluid of patients aged 45-60 years, IL-1ß decreased by 1.5 times with standard treatment, IL-4 and IL-8 decreased by two times, and IL-10 did not change, IL-22 - by 1.5 times; and using Cortexin, the concentration of IL-1ß decreased by 70%, IL-4 decreased by three times, IL-8 - by four times, IL-10 and IL-22 - by two times.Conclusion. Before treatment, the concentration of cytokines was higher in all groups of patients compared to the control values in blood serum and oral fluid. With standard therapy, the content of interleukins decreases in biological fluids, and the effect is more pronounced if standard treatment and Cortexin are combined. The correlation analysis detects that clinical manifestations of gingival inflammation are directly related to the concentration of pro- and anti-inflammatory interleukins in the blood and oral fluid.

Comparative characteristics of materials for relining complete removable dentures as part of import substitution

Relevance. Partial and complete loss of teeth are among the most common dental diseases. According to WHO, up to 75% of the world’s population suffers from them. Complete and partial secondary adentia are complex diseases that have a negative impact on the digestive, endocrine and nervous systems, as well as disrupting many other areas of the patient’s life, including social.Objective. Study of the practical features of using different materials for clinical (direct) relining of removable denture bases, identifying their inherent positive qualities and disadvantages.Materials and methods. During the clinical study, a comparative analysis of materials for direct (clinical) relining of removable dentures was carried out in 3 groups of patients. A total of 45 people took part in the study. The following materials were used: Rebaron (GC, Japan), Rebase II (Tokuyama, Japan), Nolatek (Vladmiva, Russia).Results. It was established that the group of patients with prosthetic relining with Nolatek material showed the best clinical result.Conclusion. The data we obtained allows us to conclude that the modern domestic light-curing polymer composite material Nolatek for clinical relining has a number of operational and clinical-technological advantages over cold polymerization materials.

Artificial Intelligence: An Overview of Dental Applications

Artificial intelligence (AI) is emerging as a promising modality and could be anticipated to shape the future of dental health caredelivery. Artificial intelligence is the solution that assists doctors rather than replaces them, and hence is more likely to be accepted byhealthcare professionals. Artificial Intelligence has several clinical applications and has encompassed almost all the specialties of the dentalfield. Common dental diseases such as dental caries, pulpal pathologies, bone loss, cysts, salivary gland disease, lymph node metastasis, etc.,are easily diagnosed and well treated with the help of AI and robotics. AI and Machine learning has made an excellent and impactful way ofchanging dentistry. In dentistry, AI helps predict the future of disease, that is, prognosis and treatment planning. Additionally, it will opennew avenues in research and development. Since the last few centuries, AI has shown significant growth and progress in digital technology.The applications of AI have been tremendously increased in terms of data sciences, robotic field machine intelligence and deep learning,and computer sciences. Now a day's, expert human minds get replaced by computer data, or the mind gets filled with robotic fields. Whentalking in the field of medicine and dentistry has various numbers of applications that improve the outcomes of the patient. In dentistry, AIhas played a major role in diagnosis, identifying abnormal and normal structures, and resulting in the best treatment output. This reviewgives light on the importance of the robotic field in dentistry. This review covers a combination of all aspects of artificial intelligence indentistry that should have been included in some articles. Most of the review studies focus on intelligence networks and the applications ofartificial intelligence in dentistry. The article concludes that the implementation of sources of artificial intelligence in dentistry as well as inmedical sciences with more precise results and minimum amount of error.

Adjunctive use of omega-3 fatty acids in combination with low-dose aspirin in periodontitis: Systematic review and meta-analysis.

Periodontitis is one of the most common dental diseases with a range of treatment approaches, including pathogenetically reasonable use of various host immune modulators. One such approach is the use of omega-3 polyunsaturated fatty acids (PUFAs) in combination with low-dose aspirin. This systematic review and meta-analysis were performed to compare the standard treatment alone and adjunctive use of omega-3 PUFAs in combination with low-dose aspirin with or without standard treatment in patients with periodontitis. A systematic review of the literature was performed using MEDLINE/PubMed, Cochrane Central and Google Scholar databases. Selection criteria included the following: randomized controlled trials in subjects with periodontitis in the age group above 18 years old, with follow-up periods ranging from 6 weeks to 6 months. The meta-analysis was performed using standard methodological procedures according to Cochrane recommendations, including assessment of risk-of-bias and level of evidence (GRADE). Meta-analysis was performed for such clinical outcomes as plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP) and bleeding index (BI) based on data from seven randomized clinical trials conducted between 2010 and 2020. It was shown that adjunctive use of omega-3 PUFAs in combination with low-dose aspirin results in significant clinical improvement in PD, CAL and GI during both short and prolonged follow-up periods. The use of omega-3 PUFAs and low-dose aspirin in periodontitis patients may be promising as an adjunct therapy, however, due to a limited number of patients and significant heterogeneity, further studies need to be conducted.

Results of the study of the mineralizing capacity and hydrogen indicator of the oral fluid in children taking into account the dental status and age

Caries is one of the most common dental diseases in children, which is characterized by enamel demineralization. The condition of the hard tissues of temporary and permanent teeth is influenced by a significant number of factors, including the oral fluid that is in direct contact with the teeth. The mineralizing ability of the oral fluid affects the state of the hard tissues of the teeth, that is, the acid resistance of the enamel, the decrease of which leads to demineralization with further progression of the carious process. The aim of the study was to study the indicators of the mineralizing potential and the pH of the oral fluid in children aged 7–12 years with caries of temporary and permanent teeth and to compare them with the indicators of children with intact teeth. The dental status of 223 children aged 7–12 years was studied (in each child, the condition of the hard tissues of the teeth was determined and the DMFT (Decayed, Missing and Filled Teeth) in the temporary bite, DMFT/dmft (Decayed, Missing and Filled Teeth) in the variable bite, dft (decayed and filled teeth) in the permanent bite index was calculated), mineralizing potential and pH of the oral fluid were calculated. Indicators were compared in children with and without caries. The course of caries of both temporary and permanent teeth in children occurs against the background of a decrease in pH and microcrystallization of oral fluid. This is especially noticeable in children who have affected permanent teeth. The caries rate of temporary and permanent teeth has inverse correlations with the pH and microcrystallization index of the oral fluid. The obtained data suggest the need for primary and secondary prevention, aimed at improving oral homeostasis indicators, planned remediation, which will make it possible to reduce the prevalence and intensity of caries in children, which will be the subject of our further research. Keywords: caries, intact teeth, pH of oral fluid, microcrystallization of oral fluid.

SCHOOL HEALTH PROGRAM AS AN EDUCATIONAL FACILITY IN INCREASING KNOWLEDGE ABOUT DENTAL AND ORAL HEALTH AT BUNGA BANGSA ELEMENTARY SCHOOL

Dental and oral health in Indonesia is still a health problem that requires attention. To address dental and oral health problems in Indonesia, particularly in school-age and adult groups, it is necessary to carry out promotive-preventive activities by inviting local universities and business entities that focus on dental and oral health. The most common dental and oral diseases are caries and periodontal disease. One of the strategies of the Ministry of Health of the Republic of Indonesia in reducing the number of dental caries sufferers is by declaring the "Carry Free Indonesia 2030" program. The lack of knowledge and awareness of the Indonesian population regarding dental hygiene and the difficulty of reaching information due to the geographical conditions in several regions in Indonesia which make it impossible to hamper the distribution of education. The Training of Trainer Program targets teachers and parents for 21 days of morning and evening toothbrushes, teaching children and adults about the benefits of good oral hygiene and showing them how to brush their teeth twice a day with fluoride toothpaste. This program aims to provide comprehensive, applicable and sustainable education and knowledge about dental and oral health to school-age children in Indonesia.

The Relationship Level of Knowledge of Teeth-Brushing to The Dental Caries Incidence in School-Age Children

Background: The most common dental and oral diseases are dental caries and periodontal disease. The prevalence of dental caries in Indonesia is 88.8% with a root caries prevalence of 56.6%. Children aged 5-9 years have a prevalence rate of 92.6%. Purpose: To determine the relationship between the level of knowledge of brushing teeth and the incidence of dental caries in school-age children at Genengsari 01 Elementary School, Polokarto District. Method: This type of research is correlational (correlation) with a cross sectional approach. This study used a purposive sampling technique on school-age children or grades 1-3 as many as 48 respondents. Data analysis using somers`d test. The research instrument used a questionnaire and observation of dental examination. . Result: The results of this study showed that the level of knowledge was less and the number of dental caries was higher. Somers'd test results, p value 0.001 (&lt;0.05), so it is proven that H0 from this study can be rejected, indicating a significant correlation was found between the level of knowledge of brushing teeth and the incidence of dental caries in school-age children in SD Negeri Genengsari 01 Polokarto District . The correlation coefficient value was obtained at 0.516, this means that there is a relationship between the two variables that is sufficiently correlated. Conclusion: There is a knowledge level of brushing relation to the incident of tooth caries in school-age children at Genengsari 01 Elementary School, Polokarkto District.

AKTIVITAS ANTIBAKTERI EKSTRAK TANGKAI Begonia multangula Blume TERHADAP PERTUMBUHAN Aggregatibacter actinomycetemcomitans

Periodontitis is the most common dental and oral disease found in society and can cause tooth loss. One of the bacteria that causes periodontitis is Aggregatibacter actinomycetemcomitans. Periodontitis treatment is carried out by mechanical therapy (scaling and root planning) accompanied by chemical therapy (antibiotics and mouthwash). Prolonged use of chemical therapy can cause resistance, impaired taste and discolored teeth. As an alternative, herbal ingredients that have antibacterial properties can be used. Begonia multangula Blume stalks are used in several areas as a medicinal plant and have antibacterial activity. The purpose of this study was to determine the antibacterial activity of Begonia multangula Blume stalk extract on the growth of A. actinomycetemcomitans in vitro. The study was conducted in an experimental laboratory with A. actinomycetemcomitans ATCC 43718 as a sample. Begonia multangula Blume stalks were extracted using the maceration method and 5 concentration series were made (3.12%, 6.25%, 12.5%, 25% and 50%). The antibacterial test was carried out by the paper disc diffusion method with a positive control of 2% Chlorhexidine gluconate and a negative control of 1% DMSO. The diameter of the inhibition zone was then statistically analyzed. The results showed that the antibacterial activity of Begonia multangula Blume stem extract increased with increasing concentration with the highest activity at 50% concentration with an inhibition zone of 20.33 mm (p&lt;0.05). The conclusion of this research is that the ethanol extract of Begonia multangula Blume stalk has antibacterial activity against A. actinomycetemcomitans.