Objective: To find out relationship between causes of amputation with anxiety and depression. Methodology: Three Main Rehabilitation Centers from Quetta, were involved in 3 month’s cross-sectional research. 54 subjects were included in this research. Inclusion Criteria was “newly amputees to 10years’ time since an amputation, amputees with no psychiatric illness previously, “Upper & lower limb uni-lateral amputees. Exclusion Criteria was amputation because of congenital malformation, amputees from an Afghanistan, amputees with bi-lateral Amputation. Adopted structured questionnaire “Hospital Anxiety and Depression Scale” (HADS) was used. Chi-square test was applied. Results: 47 were men while women were 7. 66.7% amputations were as a consequence of Traumatic injuries whereas 33.3% were as a result of non-traumatic causes. Regarding traumatic causes, major was RTA’s with 46.3% (25), while among non-traumatic, diabetes was the most common cause (24.1%). Tumor along with fall was less common cause for amputation (4%) contribution each. Conclusion: RTA and diabetes were the main reasons of amputation. Causes of amputation have an impact on life of these patients. Outcomes of this study can also be utilized for prevention and treatment due to various causes according to their prevalence .