In recent years, the Latin American region has suffered profound impacts because of systemic transformations such as the weak global economy, the Covid-19 pandemic, the trade war between China and the United States and even the emergence of new conflicts. This scenario implies challenges, especially for small countries in the region, such as Panama and Ecuador, which have implemented trade coordination strategies with the People’s Republic of China through free trade agreements. However, these strategies are also seen as containment mechanisms in the face of the scenario of crisis and uncertainty that characterizes the international system. The article analytically reflects on the FTA negotiation process by Panama and Ecuador with China, instruments that are part of the Commercial Diplomacy strategy as an exclusive format of negotiation and relationship with various strategic partners. The article argues that, given the vulnerability of small countries regarding recent global transformations, they have decided to implement adaptive and containment strategies with China on the commercial agenda.