Due to the globalized and transient nature of world societies, throughout the last several decades and the relative low risk involved, organized crime and related syndicates have begun to more widely exploit the lucrative market found in the trafficking of persons. After drug and arms trafficking, trafficking in persons is the third largest criminal activity in the world. Trafficking victims can be used to fuel a variety of economic demands, whether in labor industries or the billion-dollar commercial sex industry. Sub-Saharan Africa (SSA) has seen no exceptions to this terrible trend. The sub-Sahara African region has long seen cross-border and local migration including, contract workers, labor migrants, skilled professionals moving to urban areas, as well as migration by refugees and displaced persons from famine and conflict. This paper examines regional mechanisms, discusses best practices and involves case studies from Nigeria and South Africa.