Commercial Interest Research Articles

The Complex Interaction Between Sleep-Related Information, Misinformation, and Sleep Health: A Call for Comprehensive Research on Sleep Infodemiology and Infoveillance.

The complex interplay between sleep-related information-both accurate and misleading-and its impact on clinical public health is an emerging area of concern. Lack of awareness of the importance of sleep, inadequate information related to sleep, combined with misinformation about sleep, disseminated through social media, non-expert advice, commercial interests, and other sources, can distort individuals' understanding of healthy sleep practices. Such misinformation can lead to the adoption of unhealthy sleep behaviors, reducing sleep quality and exacerbating sleep disorders. Simultaneously, poor sleep itself impairs critical cognitive functions, such as memory consolidation, emotional regulation, and decision-making. These impairments can heighten individuals' vulnerability to misinformation, creating a vicious cycle that further entrenches poor sleep habits and unhealthy behaviors. Sleep deprivation is known to reduce the ability to critically evaluate information, increase suggestibility, and enhance emotional reactivity, making individuals more prone to accepting persuasive but inaccurate information. This cycle of misinformation and poor sleep creates a clinical public health issue that goes beyond individual well-being, influencing occupational performance, societal productivity, and even broader clinical public health decision-making. The effects are felt across various sectors, from healthcare systems burdened by sleep-related issues to workplaces impacted by decreased productivity due to sleep deficiencies. The need for comprehensive clinical public health initiatives to combat this cycle is critical. These efforts must promote sleep literacy, increase awareness of sleep's role in cognitive resilience, and correct widespread sleep myths. Digital tools and technologies, such as sleep tracking devices and AI-powered applications, can play a role in educating the public and enhancing the accessibility of accurate, evidence-based sleep information. However, these tools must be carefully designed to avoid the spread of misinformation through algorithmic biases. Furthermore, research into the cognitive impacts of sleep deprivation should be leveraged to develop strategies that enhance societal resilience against misinformation. Sleep infodemiology and infoveillance, which involve tracking and analyzing the distribution of sleep-related information across digital platforms, offer valuable methodologies for identifying and addressing the spread of misinformation in real time. Addressing this issue requires a multidisciplinary approach, involving collaboration between sleep scientists, healthcare providers, educators, policymakers, and digital platform regulators. By promoting healthy sleep practices and debunking myths, it is possible to disrupt the feedback loop between poor sleep and misinformation, leading to improved individual health, better decision-making, and stronger societal outcomes.

Tuning selectivity in low-temperature Fischer-Tropsch synthesis by applying gas recycle mode

While hydrocarbons production by Fischer-Tropsch synthesis (FTS) is widely recognized, commercial interest in FTS products is mainly constrained by oil prices. The FTS-derived fuels, although higher quality and greener, cannot currently compete with cheaper fossil fuels, motivating to shift the FTS products distribution to higher value-added chemicals, such as olefins-C5+. The high olefin selectivity in FTS over Co-based catalysts is usually ascribed to Co2C on the catalyst surface with its inherent deficiencies. This study demonstrates a novel approach to alter low-temperature FTS selectivity by applying off-gas recycling. At slow gas recycling rates, C19+ selectivity increases due to re-adsorption and re-incorporation into the growing chain of gaseous olefins from the off-gas. High-intensity gas recycling facilitates C5+ olefin vapors removal from the reactor by enhanced gas flow with their subsequent cut-off in the cold trap, thus reducing residence time of condensed olefins and probability of their secondary reactions.

Too Many Deaths, Too Many Left Behind: A People's External Review of the U.S. Centers for Disease Control and Prevention's COVID-19 Pandemic Response

The US population has suffered worse health consequences due to COVID-19 than comparable wealthy nations. COVID-19 had caused over 1.1 million deaths in the United States as of May 2023 and contributed to a 3-year decline in life expectancy. A coalition of public health workers and community activists launched an external review of the CDC's pandemic management from January 2021 to May 2023. We used a modified Delphi process to identify core pandemic management areas, which formed the basis for a survey and literature review. Our analysis yields three overarching shortcomings of the CDC's pandemic management: 1) CDC leadership downplays the serious impacts and aerosol transmission risks of COVID-19; 2) CDC leadership has aligned public guidance with commercial and political interests over scientific evidence; 3) CDC guidance focuses on individual choice rather than emphasizing prevention and equity. Instead, the agency must partner with communities most impacted by the pandemic and encourage people to protect each other using layered protections to decrease COVID-19 transmission. As emerging variants can already evade existing vaccines and treatments, and long COVID can be disabling and lacks definitive treatment, multifaceted, sustainable approaches to the COVID-19 pandemic are essential to protect people, the economy, and future generations.

Dancemania: Analyzing the Commercialization of Dance Crew Competitions

This research delves into the intricate landscape of commercialization within dance crew competitions, employing a focused examination of prominent television series, notably the widely recognized "Dancemania." As the dance competition model gains unprecedented popularity and financial success, there is a discernible risk that the core authenticity of this expressive art form may be compromised. Rather than adhering to artistic values, there is a growing concern that these competitions may veer towards catering primarily to mass entertainment tastes. To comprehensively unravel the increasing commercial influences and economic incentives shaping the competition format, this study employs a multifaceted approach. Interviews and surveys are conducted, drawing perspectives from dance professionals, competitors, and television producers intimately involved in the dance competition milieu. Through qualitative insights and firsthand accounts, the paper aims to shed light on the evolving dynamics propelled by commercial interests. Quantitative data analysis forms a critical component of this research, uncovering correlations that exist between success metrics and influential factors, such as viewership ratings, which may take precedence over the technical prowess of dance ability. The findings from this analysis serve as a catalyst for discussions surrounding potential policy and structural adjustments. The overarching objective is to realign the priorities of competitive dance with a renewed emphasis on artistic values, countering the prevailing trend of prioritizing commercial interests. This research signals the need for holistic interventions and shifts in the competition landscape to preserve the inherent artistic integrity of dance within a commercialized context.

Decoding dietary myths: The role of ChatGPT in modern nutrition

In today's world, where nutrition forms the cornerstone of human health, the potential harms of misinformation are concerning. Nutritional myths, whether originating from age-old superstitions, misinterpreted scientific findings, or commercial interests, can lead astray. In the digital age, the proliferation of such misleading information is alarmingly accelerated, thanks to the dominance of social media and search engines. Modern artificial intelligence tools, exemplified by ChatGPT, promise a potential revolution in dispelling these nutrition-related misconceptions. ChatGPT, by offering users immediate and scientifically-backed information, aids in illuminating nutritional myths and misconceptions. However, such AI models come with inherent limitations and potential ethical concerns. Therefore, while tools like ChatGPT are undoubtedly powerful, they are not a panacea. In conclusion, AI stands as a pivotal tool in the dissemination of nutritional knowledge and debunking myths, but a careful and critical approach must be adopted in its usage.

Preliminary assessment of environmental safety (ecosafety) of dextrin-based nanosponges for environmental applications

The ability to employ waste products, such as vegetable scraps, as raw materials for the synthesis of new promising adsorbing materials is at the base of the circular economy and end of waste concepts. Dextrin-based nanosponges (D_NS), both cyclodextrin (CD) and maltodextrin (MD), have shown remarkable adsorption abilities in the removal of toxic compounds from water and wastewater, thus representing a bio-based low-cost solution which is establishing itself in the market. Nevertheless, their environmental safety for either aquatic or terrestrial organisms has been overlooked, raising concern in terms of potential hazards to natural ecosystems. Here, the environmental safety (ecosafety) of six newly synthesized batches of D_NS was determined along with their full characterization by means of dynamic light scattering (DLS), thermogravimetric analysis (TGA), Fourier transformed infrared spectroscopy with attenuated total reflection (FTIR-ATR) and transmission electron microscopy (SEM). Ecotoxicity evaluation was performed using a battery of model organisms and ecotoxicity assays, such as the microalgae growth inhibition test using the freshwater Raphidocelis subcapitata and the marine diatom Dunaliella tertiolecta, regeneration assay using the freshwater cnidarian Hydra vulgaris and immobilization assay with the marine brine shrimp Artemia franciscana. Impact on seedling germination of a terrestrial plant of commercial interest, Cucurbita pepo was also investigated. Ecotoxicity data showed mild to low toxicity of the six batches, up to 1 mg/mL, in the following order: R. subcapitata >H. vulgaris >D. tertiolecta >A. franciscana > C. pepo. The only exception was represented by one batch (NS-Q+_BDE_(GLU2) which resulted highly toxic for both freshwater species, R. subcapitata and H. vulgaris. Those criticalities were solved with the synthesis of a fresh new batch and were hence attributed to the single synthesis and not to the specific D_NS formulation. No effect on germination of pumpkin but rather more a stimulative effect was observed. To our knowledge this is the first evaluation of the environmental safety of D_ NS. As such we emphasize that current formulations and exposure levels in the range of mg/mL do not harm aquatic and terrestrial species thus representing an ecosafe solution also for environmental applications.

Analysis of Migratory Catfish Production from Artisanal Fishing in the Middle Madeira Sub-Basin Using New Monitoring Methods, Southwestern Amazon

Studies on the production of Pimelodidae catfish in the Amazon are generally carried out in large fishing centers. However, the data referring to small-scale fisheries have gaps that can represent a risk to the activity. This study evaluated the volume produced and the revenue obtained from migratory catfish of the Pimelodidae family of commercial interest landed in Humaitá, Amazonas, Brazil, from May 2018 to April 2019. Daily monitoring was carried out with the Z-31 Fishermen’s Colony through questionnaires to fishermen for each vessel docked. The total production was 6013.93 kg, with 1,689 fish counted and 13 species. A total of 186 landings by 122 fishermen in 24 fishing sites characterized as rivers, lakes, and “igarapés” were evaluated. The average selling price was R$5.57/kg, and the highest volumes were obtained from July to September, mainly with gillnets, where the “Surubim” Pseudoplatystoma punticfer had the highest volume and revenue. Low productivity was verified in most localities, characterizing the fishing as artisanal. The lack of adequate conditions for storing and transporting fish, the local hydrological variations, and the presence of hydroelectric plants on the Madeira River are major factors limiting the fishing expansion in southern Amazonas.

A systematic literature review of the 'commercialisation effect' on public attitudes towards biobank and genomic data repositories.

Initiatives that collect and share genomic data to advance health research are widespread and accelerating. Commercial interests in these efforts, while vital, may erode public trust and willingness to provide personal genomic data, upon which these initiatives depend. Understanding public attitudes towards providing genomic data for health research in the context of commercial involvement is critical. A PRISMA-guided search of six online academic databases identified 113 quantitative and qualitative studies using primary data pertaining to public attitudes towards commercial actors in the management, collection, access, and use of biobank and genomic data. The presence of commercial interests yields interrelated public concerns around consent, privacy and data security, trust in science and scientists, benefit sharing, and the ownership and control of health data. Carefully considered regulatory and data governance and access policies are therefore required to maintain public trust and support for genomic health initiatives.

Multisectoral action to address noncommunicable diseases: lessons from three country case studies.

Multisectoral action is a central component of the global response to the rising prevalence of non-communicable diseases (NCDs). In this paper we aimed to unpack the definition of multisectoral action and provide an overview of the historical context, challenges, and recommendations alongside three country case studies: salt reduction in the UK, tobacco legislation in Nigeria, and regulation of edible oils in Iran. We used an iterative review process to select three country case studies from a list of 20 potential cases previously identified by WHO. At our third round of review we unanimously agreed to focus on salt reduction in the UK, tobacco regulation in Nigeria, and edible oil regulation in Iran as these represented rich cases on diverse risk factors from three different world regions that we felt offered important lessons. We conducted literature reviews to identify further data for each case study. Across the three studies a number of important themes emerged. We found that multisectoral approaches demand the often difficult reconciliation of competing and conflicting values and priorities. Across our three chosen cases, commercial interests and free trade agreements were the most common obstacles to successful multisectoral strategies. We found that early consultative stakeholder engagement and strong political and bureaucratic leadership were necessary for success. The complex multi-rooted nature of NCDs requires a multisectoral approach, but the inevitable conflicts that this entails requires careful navigation.

Metabolic model-based ecological modeling for probiotic design.

The microbial community composition in the human gut has a profound effect on human health. This observation has lead to extensive use of microbiome therapies, including over-the-counter 'probiotic' treatments intended to alter the composition of the microbiome. Despite so much promise and commercial interest, the factors that contribute to the success or failure of microbiome-targeted treatments remain unclear. We investigate the biotic interactions that lead to successful engraftment of a novel bacterial strain introduced to the microbiome as in probiotic treatments. We use pairwise genome-scale metabolic modeling with a generalized resource allocation constraint to build a network of interactions between taxa that appear in an experimental engraftment study. We create induced sub-graphs using the taxa present in individual samples and assess the likelihood of invader engraftment based on network structure. To do so, we use a generalized Lotka-Volterra model, which we show has strong ability to predict if a particular invader or probiotic will successfully engraft into an individual's microbiome. Furthermore, we show that the mechanistic nature of the model is useful for revealing which microbe-microbe interactions potentially drive engraftment.

Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro-nutraceuticals.

Arising out of a PhD project more than 50 years ago to synthesise analogues of the neurotransmitter GABA, a series of new chemical entities were found to have selective actions on ionotropic GABA receptors. Several of these neurochemicals are now commercially available. A new subtype of these receptors was discovered that could be a target for the treatment of myopia, the facilitation of learning and memory, and the improvement of post-stroke motor recovery. The development of these new chemical entities over many years demonstrates the importance of neurochemicals with which to investigate selective aspects of GABA receptors and illustrates the significance of collaboration between chemists and biologists in neurochemistry. Vital were the improvements in synthetic organic chemistry and the use of functional human receptors expressed in oocytes. Current interest in ionotropic GABA receptors includes the clinical development of subtype-specific agents and the role of gain-of-function receptor variants in epilepsy. Dietary flavonoids were found to cross the blood-brain barrier to influence brain function. Natural and synthetic flavonoids had a range of effects on GABA receptors, ranging from positive, silent, and negative allosteric modulators, to even second-order modulation of first-order modulators. Flavonoids have been called "a new family of benzodiazepines." Like benzodiazepines, flavonoids reduce stress. Stress produces changes in GABA receptors in the brain that may be because of changes in endogenous modulators, such as neurosteroids and corticosteroids. GABA also occurs naturally in the diet leading to studies of the effects of oral GABA on brain function. This finding has resulted in studies of GABA and related neurochemicals as neuro-nutraceuticals. GABA systems in the gut microbiome are essential to such studies. The actions of oral GABA and of GABA-enriched beverages and foodstuffs are now an area of considerable scientific and commercial interest. GABA is a deceptively simple chemical that can take up many shapes, which may underlie its complex functions. The need for new chemical entities with selective actions for further studies highlights the need for continuing collaboration between chemists and biologists.

Size at Sexual Maturity of Deep-Sea Unexploited Caribbean Metanephrops binghami (Boone, 1927) and Overexploited Mediterranean Nephrops norvegicus (Linnaeus, 1758) Using Morphometric and Gonadal Staging Approaches

The deep-sea Caribbean lobster (Metanephrops binghami) and the Norway lobster (Nephrops norvegicus) are Nephropidae species of high commercial interest. Although the first one still remains unexploited, the second is overexploited in the Mediterranean Sea. For effective fisheries management, size at sexual maturity is an essential indicator to protect immature individuals from exploitation. The estimation of this indicator can, however, be biased due to the difficulty of differentiating juveniles from adults by their size structure due to the natural process of molting. This study aims to estimate the size at sexual maturity of M. binghami and N. norvegicus females by comparing the effectiveness of the morphometric method versus the macroscopic evaluation of gonad maturity. Samples of M. binghami were collected from the Colombian Caribbean Sea in August and December 2009, March and May 2010, and August 2020 to May 2021. Samples of N. norvegicus were collected from the northwestern Mediterranean Sea from 2019 to 2022. Similar sizes at sexual maturity were found for M. binghami between the morphometric approach (ranging from 28.6 to 33.9 mm cephalothorax length, CL) and the gonadal staging approach (31.4 mm CL). Conversely, for N. norvegicus, the morphometric approach yielded higher measurements (between 27.2 and 30.4 mm CL) than the gonadal approach (26.0 mm CL). This discrepancy might stem from the intense fishing overexploitation conditions of N. norvergicus, leading to a physiological adaptation that enables earlier gonadal maturation at faster rates than morphometric adaptation. Further research is required to elucidate these discrepancies and the effect of overexploitation on physiological (i.e., mature gonads) and functional maturity (i.e., capacity to brood eggs at a larger size).

Inside out. Social media videos and destination branding. Neuromarketing using EEG technique

PurposeThis study aims to investigate the effectiveness of two types of social media videos used for destination image development: induced/commercial-oriented content and organic content (where content is made without commercial interest, such as vlogs classified as user-generated content).Design/methodology/approachExperimental research using “Emotive EEG” (electroencephalogram) in a controlled environment was conducted with 30 participants (20 males, 10 females), age range 18 to 26. Emotive EEG recording was performed while the participants watched both types of video clips. Test results for both groups indicate that induced content is preferred over organic content.FindingsThis study opens up future research avenues where neuromarketing’s “Marketer Friendly” EEG equipment can be applied to the customer selection process.Originality/valueMarketing analysts can gauge the interest and response of customers on different types of social media video content for destination marketing based on the findings of this study.

Whipsawed by Woori and Washington: South Korea's growing challenges in handling Middle Eastern affairs

AbstractThe history of the past two decades has proved that top Korean leaders can make a real difference in terms of their previous experiences and personal engagement in securing the Republic of Korea's (ROK) vested interests in the Middle East. For decades, South Korea had handed over its day‐to‐day interactions with Middle Eastern countries to the Korean bureaucracy led by the relevant departments and subaltern officials at the foreign ministry and other state institutions. This approach, however, seems rather dysfunctional today, requiring key Korean officials, especially the president, to get involved personally in the ROK's increasingly multifaceted relationships with Middle Eastern nations. This article reappraises the new Korean orientation by highlighting some of the major developments involving both sides during the past several years. The main argument is that the ROK is facing increasingly serious difficulties in sorting out its policy behaviors toward Middle Eastern countries as Korea is striving to strike a delicate balance between its own expanding commercial interests in the region and what the United States expects from South Korea with regard to the topsy‐turvy world of politics in the Middle East.

India and the Artemis Accords: Need to Tread Cautiously

The Artemis Accords refer to a non-binding multilateral arrangement on use of space led by the US and signed onto by several governments. These accords have established a framework of principles, guidelines, and best practices to ensure peaceful space exploration in a transparent manner. India signed the Artemis Accords in June 2023. India becoming a part of these accords is viewed as an important step towards expanding the Indo-US strategic partnership further. However, these accords are in conflict with the concept of Common Heritage of Mankind (CHM). The final aim of the Artemis Programme is to facilitate the outreach of humans to the Moon and Mars. Some provisions in these accords are at variance with the existing norms building process in the space domain. This article identifies the limitations of these accords and argues that as a signatory nation, India needs to remain watchful and ensure that its strategic and commercial interests are well protected.

The state of the organ trade: Narratives of corruption in Egypt and Bangladesh

AbstractThis paper provides a comparative analysis of the trade in human organs in Egypt and Bangladesh. The authors draw on extensive qualitative and ethnographic fieldwork in both countries to assess the efficacy of legal measures in response to the organ trade. Despite the introduction of tough criminal sanctions in Egypt and Bangladesh the buying and selling of organs (e.g., kidneys, liver lobes) has continued unabated. Although there have been some sporadic attempts from law enforcement to curb organ trading, political indifference to the bodies of the poor and vested commercial interests (of state and non-state actors) means that the organ trade remains a relatively low risk crime with high profits. Adopting the view that support not punishment is integral to reducing crime we argue that enhancing social support, e.g., increasing public expenditure on healthcare, would limit demand for illegal transplants and disrupt the symbiotic arrangements that underpin organ markets.

Cancer researchers’ experiences with and perceptions of research data sharing: Results of a cross-sectional survey

ABSTRACT Background: Despite wide recognition of the benefits of sharing research data, public availability rates have not increased substantially in oncology or medicine more broadly over the last decade. Methods: We surveyed 285 cancer researchers to determine their prior experience with sharing data and views on known drivers and inhibitors. Results: We found that 45% of respondents had shared some data from their most recent empirical publication, with respondents who typically studied non-human research participants, or routinely worked with human genomic data, more likely to share than those who did not. A third of respondents added that they had previously shared data privately, with 74% indicating that doing so had also led to authorship opportunities or future collaborations for them. Journal and funder policies were reported to be the biggest general drivers toward sharing, whereas commercial interests, agreements with industrial sponsors and institutional policies were the biggest prohibitors. We show that researchers’ decisions about whether to share data are also likely to be influenced by participants’ desires. Conclusions: Our survey suggests that increased promotion and support by research institutions, alongside greater championing of data sharing by journals and funders, may motivate more researchers in oncology to share their data.

Breeding of ornamental orchids with focus on Phalaenopsis: current approaches, tools, and challenges for this century.

Ornamental orchid breeding programs have been conducted to develop commercially valuable cultivars with improved characteristics of commercial interest, such as size, flower color, pattern, shape, and resistance to pathogens. Conventional breeding, including sexual hybridization followed by selection of desirable characteristics in plants, has so far been the main method for ornamental breeding, but other techniques, including mutation induction by polyploidization and gamma irradiation, and biotechnological techniques, such as genetic transformation, have also been studied and used in ornamental breeding programs. Orchids are one of the most commercially important families in floriculture industry, having very particular reproductive biology characteristics and being a well-studied group of ornamentals in terms of genetic improvement. The present review focuses on the conventional and biotechnological techniques and approaches specially employed in breeding Phalaenopsis orchids, the genus with highest worldwide importance as an ornamental orchid, highlighting the main limitations and strengths of the approaches. Furthermore, new opportunities and future prospects for ornamental breeding in the CRISPR/Cas9 genome editing era are also discussed. We conclude that conventional hybridization remains the most used method to obtain new cultivars in orchids. However, the emergence of the first biotechnology-derived cultivars, as well as the new biotechnological tools available, such as CRISPR-Cas9, rekindled the full potential of biotechnology approaches and their importance for improve ornamental orchid breeding programs.

Can Some Anticancer Drugs Be Repurposed to Treat Amyotrophic Lateral Sclerosis? A Brief Narrative Review.

Amyotrophic lateral sclerosis (ALS) is a rare progressive motor neuron disease that, due to its high complexity, still lacks effective treatments. Development of a new drug is a highly costly and time-consuming process, and the repositioning of approved drugs can represent an efficient strategy to provide therapeutic opportunities. This is particularly true for rare diseases, which are characterised by small patient populations and therefore attract little commercial interest. Based on the overlap between the biological background of cancer and neurodegeneration, the repurposing of antineoplastic drugs for ALS has been suggested. The objective of this narrative review was to summarise the current experimental evidence on the use of approved anticancer drugs in ALS. Specifically, anticancer drugs belonging to different classes were found to act on mechanisms involved in the ALS pathogenesis, and some of them proved to exert beneficial effects in ALS models. However, additional studies are necessary to confirm the real therapeutic potential of anticancer drugs for repositioning in ALS treatment.

Diversity and genetic structure of freshwater shark Wallago attu: an emerging species of commercial interest.

Pakistan has natural freshwater resources acting as a hotspot for diverse fish fauna. However, this aquatic fauna is declining at an alarming rate due to over-exploitation, habitat degradation, water pollution, climate change, and certain anthropogenic activities. The freshwater shark, Wallago attu, is a popular edible catfish inhabiting these freshwater ecosystems. Habitat degradation, overfishing, and human activities are heavily impacting the natural population of this species. So, sound knowledge about its population structure is necessary for its proper management in natural waters. The current study involves utilizing two mtDNA markers (COI, Cytb) to assess the genetic structure and differentiation among W. attu populations of Pakistani Rivers. Genetic variability analysis indicated a high haplotype (0.343 ± 0.046-0.870 ± 0.023) and low nucleotide diversity (0.0024 ± 0.012-0.0038 ± 0.018) among single and combined gene sequences, respectively. Overall, River Indus was populated with more diverse fauna of Wallago attu as compared to River Chenab and River Ravi. Population pairwise, Fst values (0.40-0.61) were found to be significantly different (p < 0.01) among three Riverine populations based upon combined gene sequences. The gene flow for the combined gene (COI + Cytb) dataset among three populations was less than 1.0. The transition/transversion bias value R (0.58) was calculated for testing of neutral evolution, and it declared low genetic polymorphism among natural riverine populations of Wallago attu. The current study's findings would be meaningful in planning the management and conservation of this economically important catfish in future.