In this conceptual paper, I propose an interpretation of business dynamics in terms of the spatial co-localisation of firms—considered as an intelligent cognitive system—in a circumscribed area in order to form clusters of various types. I interpret clustering by adopting the methodology of multi-agent combinatory systems: that is, systems formed by collectivities of agents (firms) in which an internal feedback recombines the micro behaviours of the agents (localisation) in order to produce a macro effect (cluster) which, in turn, modifies the attractiveness of the area and conditions the subsequent localisations. I also present the idea that if a cluster has fitness advantages for new firms, then usually new entrepreneurs are formed within it and the cluster widens, due to the endogenous genesis of new firms.