Due to the reduction in device feature size and supply voltage, achieving soft error reliability in sub-micrometer digital circuits is becoming extremely challenging. We consider the problem of choosing the gate sizes in a combinational logic circuit in order to minimize the soft error rate (SER) of the circuit. This problem can be solved using the heuristic as well as the greedy-based approaches for small-size problems; however, when the circuit size increases, the computational time grows exponentially, and hence, the previous methods become impractical. This paper proposes a novel technique for soft error tolerant design of large-scale combinational circuits using a cone-oriented gate sizing. Circuit partitioning is used to split the circuit into a set of small sub-circuits. The gates of sub-circuits are resized, such that the entire circuit SER is reduced based on a new soft error descriptor metric. The proposed cone-oriented gate sizing framework is used for selective gate sizing, leading up to 31% SER reduction with less than 17% area overhead when applied to large-scale benchmarks. The results also show that the proposed method is 21% more efficient and up to 292 times faster when compared with that obtained using a similar work based on the sensitive-based gate sizing scheme.