Analysis Of Combinatorial Libraries Research Articles

Explainability and human intervention in autonomous scanning probe microscopy

The broad adoption of machine learning (ML)-based autonomous experiments (AEs) in material characterization and synthesis requires strategies development for understanding and intervention in the experimental workflow. Here, we introduce and realize a post-experimental analysis strategy for deep kernel learning-based autonomous scanning probe microscopy. This approach yields real-time and post-experimental indicators for the progression of an active learning process interacting with an experimental system. We further illustrate how this approach can be applied to human-in-the-loop AEs, where human operators make high-level decisions at high latencies setting the policies for AEs, and the ML algorithm performs low-level, fast decisions. The proposed approach is universal and can be extended to other techniques and applications such as combinatorial library analysis.

Apparatus and methods for optical time-of-flight discrimination in combinatorial library analysis

Our recently developed method for combinatorial synthesis leads efficiently to linear arrays, where the location of a compound in the array encodes its complete synthetic history. Such arrays prepared using an optical fiber as a linear support can be probed with a fiber-guided pulse, allowing evanescent interaction with fluorescent probe molecules at the core-cladding interface. Optical time-of-flight distinction among output signals of fluorescent regions distributed along the fiber is carried out, allowing for the measurement of the location of the emitting fluorescent probes. A unique two-fiber, double-evanescent process overcomes limitations in spatial discrimination, due to fluorescence decay times in comparison to the speed of light. Investigation of an array of 102 fluorescent regions is described, with discussion of its features and limitations.

ChemInform Abstract: Sampling Accessories for the High‐Throughput Analysis of Combinatorial Libraries Using Spectral Imaging

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Molecular Recognition and Solid Phase Organic Synthesis: Synthesis of Unnatural Oligomers, Techniques for Monitoring Reactions, and the Analysis of Combinatorial Libraries

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Recent Developments and Applications of High-Performance Liquid Chromatography-Eiectrospray Ionization Mass Spectrometry

The technique of high-performance liquid chromatography (HPLC)/electrosprayionization (ESI)/mass spectrometry (MS) is one of the most exciting developments of recent times in analytical methodology. With this combination, a variety of thermally labile, polar, and nonvolatile compounds present in a complex matrix can be separated and characterized unambiguously. This review will discuss the basics of ESI process, key issues of primary concern in the use of HPLC/ESI/MS, and various HPLC/ESI systems. An overview of timely applications of HPLC/ESI/MS in characterization of proteins, peptides , and oligosaccharides, analysis of combinatorial libraries, detection of posttranslational modifications in proteins, degradation of bioactive peptides, and quantification of peptides, pharmaceutical drugs, toxins and their metabolites, will be presented.

ChemInform Abstract: Similarity Measures for Rational Set Selection and Analysis of Combinatorial Libraries: The Diverse Property‐Derived (DPD) Approach.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

A simple multiple release system for combinatorial library and peptide analysis

A method which allows the portion wise release of compounds from an insoluble support is described. The synthesis of the multiple release system is exceptionally simple and easy to modify to allow the quantities of compound released to be controlled and will have wide applicability in the screening and analysis of combinatorial libraries.