Combination Of Xanthan Gum Research Articles

PHYSICAL, CHEMICAL AND SENSORY PROPERTIES OF SUGAR‐FREE JELLY*

ABSTRACT The increase in diabetes and obesity has increased the demand for sugar‐free/low‐calorie products. Three jelly formulations were prepared using sucralose, low‐methoxyl pectin and maltodextrin with either xanthan gum or locust bean gum (LBG) used singly or in combination and stored at 4C or 43C for shelf life evaluation. Jelly treatments were evaluated for chemical, physical and sensory properties. The combination of xanthan gum and LBG significantly reduced syneresis compared with either gum used singly. The combination of xanthan gum and LBG resulted in significantly higher firmness and springiness values than using xanthan gum or LBG alone. The overall acceptability, aroma, taste, texture, spreadability and sensory attributes for no sugar‐added grape jelly averaged 5.8–6.4 in a 9‐point hedonic scale consumer acceptance study.

In vitro and in vivo evaluation of a xanthan gum- n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug

The bioavailability after oral administration of two sustained release ibuprofen formulations using xanthan gum and a combination of n-octenylsuccinate starch (CL490) and xanthan gum has been investigated in healthy human volunteers and compared with a commercial suspension formulation. The ibuprofen-xanthan gum and the ibuprofen-xanthan gum-CL490 matrix tablets were prepared by direct compression. Three different xanthan gum/CL490 ratios (1:1; 1:4 and 1:10) were investigated in vitro. The xanthan gum/CL490 matrix tablets of a 1 4 and a 1 10 ratio both released nearly 100% after 24 h. No difference was observed in the release profiles between the matrix tablets prepared with 1 1 ratio of xanthan gum and CL490 and with pure xanthan gum during the first 8 h of dissolution test. After 8 h, the release rate from the pure xanthan gum matrix increased (nearly 90% after 24 h) while matrix tablet with a 1 1 ratio of xanthan gum and CL490 released 60% after 24 h. A dry core remained after a 24 h dissolution time period for matrix tablets prepared with the 1 1 ratio of xanthan gum and CL490, while the pure xanthan gum matrix had completely eroded. For the in vivo study, a xanthan gum/CL490 (1:1) matrix tablet was compared to a xanthan gum matrix tablet and a conventional suspension formulation. In comparison with the conventional suspension, the oral bioavailability was 86.83% ± 25.80% ( n = 6) and 75.50% ± 17.18% ( n = 6) for the tablets made with xanthan gum and with a combination of xanthan gum and CL490 (ratio 1 1 ), respectively. The combination of a xanthan gum and CL490 seemed to avoid the initial slow absorption phase in vivo that occurred with a pure xanthan gum matrix tablet. The combination of xanthan gum and n-octenylsuccinate starch could offer some advantages in the formulation of sustained release hydrophilic matrix tablets.

<i>In vitro</i> Release Kinetics Study of Diclofenac Sodium from Acrylic Polymer Coated Pellets

The aim of the present study is to investigate the effect of Ammonio Methacrylate Copolymer Type B (Eudragit RS 30 D) on the release kinetics study of diclofenac sodium form coated pellets. The effect of the incorporation of xanthan gum into the coating formulation was also the goal of this study. Eudragit RS 30 D and xanthan gum was added into the formulation at 5:1 ratio. Different percent of this polymeric combination was loaded on to the drug-loaded pellets. It was found that the cumulative % release of drug decreased with the increase of polymer load in all cases. From all formulations it was observed that the release of diclofenac sodium in 0.1N HCl media was very low (maximum 3.5%) at first 2 hours. Better sustaining effect was found from Eudragit RS 30 D and xanthan gum combinations. Drug was released linearly along with time throughout the whole dissolution process in phosphate buffer (pH 6.8) and it was also revealed that, in all cases the release of diclofenac sodium followed mixed release kinetics but zero order release kinetics predominates. 
 
 Key words: Diclofenac sodium, pellets, sustained release, in vitro, kinetic analysis. 
 
 Dhaka Univ. J. Pharm. Sci. 6(1): 1-7, 2007 (June)
 
 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website