This study provides a comparative assessment of the effectiveness of active ingredients of fungicidal preparations and in a mixture with organomineral fertilizers on reducing the infection of seed and the germination of spring wheat plants in the initial phases of ontogenesis. For the research, on 8 different combinations of active ingredients fungicides in pure form and in a mixture with organomineral fertilizer. The application of fungicide did not affect the seed growth energy, but in most cases the germination rate increased by 4%. Seed dressing had a retardant effect on germination of the plant’s organs, and the fertiliser stimulating effect was shown in Variant 1 (Protioconazole + Tebuconazole + fertiliser). The efficiency of disinfectants against seed diseases reached 96% against general contamination and 56-93% against pathogenic microflora, and in a mixture with organomineral fertilizer, the efficiency is reduced by 13%. High and stable efficiency was manifested in drugs based on the active substances Tebuconazole + Flutriafol (80 + 80 g/l). Protioconazole + Tebuconazole (250+150 g/l) with net efficiency of 83-93%. As a result of the research, the effect of pickling with fungicides was determined on the basis of various combinations of active substances in pure form and with the addition of organomineral fertilizer as a growth stimulator.