Combination Of Active Components Research Articles

Imaging privacy threats from an ambient light sensor.

Embedded sensors in smart devices pose privacy risks, often unintentionally leaking user information. We investigate how combining an ambient light sensor with a device display can capture an image of touch interaction without a camera. By displaying a known video sequence, we use the light sensor to capture reflected light intensity variations partially blocked by the touching hand, formulating an inverse problem similar to single-pixel imaging. Because of the sensors' heavy quantization and low sensitivity, we propose an inversion algorithm involving an ℓp-norm dequantizer and a deep denoiser as natural image priors, to reconstruct images from the screen's perspective. We demonstrate touch interactions and eavesdropping hand gestures on an off-the-shelf Android tablet. Despite limitations in resolution and speed, we aim to raise awareness of potential security/privacy threats induced by the combination of passive and active components in smart devices and promote the development of ways to mitigate them.

Active metals decorated NiCo2O4 yolk-shell nanospheres as nanoreactors for catalytic reduction of nitroarenes and azo dyes

Transition-metal oxides (TMOs) have received a great deal of research attention and have been widely used in a variety of fields. However, conventional TMOs do not possess high specific surface area, sufficient active site on their surfaces, and limited their applications in catalysis. This study presents a two-step method for synthesizing active metal (M) decorated NiCo2O4 (M/NiCo2O4, M = Pd or Cu) nanospheres with yolk-shell nanostructures. Taking advantage of the unique morphology and the combination of dual active components (i.e., active NiCo2O4 substrate and decorated active metal), the as-prepared M/NiCo2O4 yolk-shell nanospheres can be employed as nanoreactors in the organic reactions. In catalyzing the reduction of a representative nitroarene (i.e., 4-NP) by NaBH4, the Pd/NiCo2O4 nanoreactors exhibit a superior catalytic efficiency to their counterparts (Cu/NiCo2O4 and NiCo2O4). The turnover frequency is much higher than that of various TMOs supported nanocatalysts have been reported over the past five years. Furthermore, the Pd/NiCo2O4 nanoreactors show excellent stability and common applicability of the reduction of various substituted nitrobenzenes and azo dyes. This work provides new rational design concept and preparation strategy for efficient nanoreactors with dual active components and sheds light on the practical application of chemical reactions.

NiSe2-CoSe2 hollow polyhedron as counter electrode catalyst for high-efficiency dye-sensitized solar cells

The design of efficient counter electrode (CE) materials for dye sensitized solar cells (DSSCs) strongly depend on the microstructure construction and the effective combination of different active components. In this study, a hollow polyhedral structured NiSe2-CoSe2 composite electrode was synthesized through the direct selenization of the hollow nanocage morphology nickel-cobalt layered double hydroxide (NiCo-LDH) ultrathin nanosheets, which was derived from ZIF-67 nanocrystals. Notably, owing to the unique hollow structure and synergistic effect of the Ni-Co bimetallic selenides, the hollow polyhedral NiSe2-CoSe2 CE exhibited the expected electrochemical catalytic activity in the reduction of triiodide, as revealed by electrochemical impedance spectroscopy, cyclic voltammetry and Tafel polarization measurements. The photovoltaic results revealed that the PCE of the NiSe2-CoSe2 CE reached 8.21 %, which was higher than those of the Pt and CoSe2 CEs (7.62 % and 6.78 %, respectively). Moreover, the hollow NiSe2-CoSe2 CE exhibited a favourable photocurrent response upon light on-and-off cycling and improved stability over multiple start. This study provides a meaningful reference for the construction of hollow polymetallic transition-metal selenides for DSSC devices.

The Combination of Individual Herb of Mi-Jian-Chang-Pu Formula Exerts a Synergistic Effect in the Treatment of Ischemic Stroke in Rats.

Mi-Jian-Chang-Pu formula (MJCPF), composed of Crocus sativus L. and Acorus tatarinowii Schott, is a well-known TCM for treatment of hemiplegia, facial paralysis as well as language dysfunction caused by stroke both in ancient and modern times. By using pharmacodynamics, pharmacokinetics, and metabolomics, our present study discusses whether the combination of individual herbs or major active components of MJCPF possess synergistic neuroprotective effects against ischemic stroke (IS). 108 adult male Sprague-Dawley rats were randomly and equally divided into 9 groups, including sham group (N, vehicle), middle cerebral artery occlusion (MCAO) model group (M, vehicle), positive group (P, 36 mg/kg/day nimodipine), crocin I (A1, 40 mg/kg/day), β-asarone (B1, 15 mg/kg/day), crocin I + β-asarone (A1B1, 55 mg/kg/day), C. sativus (A, 580 mg/kg/day), A. tatarinowii (B, 480 mg/kg/day), and C. sativus + A. tatarinowii, also named MJCPF (AB, 1060 mg/kg/day) groups. All drugs were orally administered to rats once a day for 14 consecutive days. Neurological deficit score, cerebral infarct volume, body weight change, TTC, HE and IHC staining, behavioral evaluation, metabolic profiles, and pharmacokinetic parameters were determined. MCAO led to severe brain damage including large infarct volume, more severe brain tissue injury, and worse neurological function as compared to the sham rats. All treatment groups showed a significant neuroprotective effect on MCAO rats. Furthermore, the pharmacodynamics' results demonstrated that MJCPF had a synergistic effect evidenced by small infarct volume, more regular arrangement of neuronal cells, and more improved neural function, and the levels of inflammatory factors were closer to normality. A total of 53 differential metabolites between MCAO and sham groups were screened by integration of serum and brain metabolisms, all of which were restored at varying degrees in treatment. PCA and PLS-DA analysis showed that the levels of differential metabolites treated with MJCPF were closer to the sham group than the individual herb and single compound alone or A1B1 combination. The pharmacokinetic parameters further verified the above results that MJCPF could synergistically promote drug absorption greater than others. Our integrated pharmacodynamics, metabolomics, and pharmacokinetic approach reveals the synergistic effect of MJCPF on treatment of IS, which powerfully contribute to the understanding of scientific connotation of TMC formula.

Theoretical innovation of component-based Chinese medicine and its exemplary practice: the study on creating Guanxinning Tablets

Upholding the wisdom of traditional Chinese medicine that the therapeutic principle, method, formula and medicine are coherent with each other, we propose the technical methodology for intelligent creation of component-based Chinese medicine by integrating multidisciplinary knowledge such as artificial intelligence, pharmaceutical informatics, system pharmacology and phytochemistry. Taking the creation of Guanxinning Tablets as an example, we expound the technical principle for creating component-based Chinese medicine and briefly describe the design method for optimizing the entity of Chinese medicine efficacy by rational combination of active components. Our research sought to "clarify and explain" the mechanism of its clinical treatment action through multi-modal and multi-scale systematic pharmacology studies. This work emphatically demonstrates the pilot workshop and engineering validation platform based on the intelligent simulation of whole production process, and outlines the design principles of the intelligent production line for innovative Chinese medicine. The results of industrial research show that the ourself established method for evaluating the process quality controllability and intelligent production line can be applied to manufacturing Guanxining Tablets with high quality. Through the innovative research of multidisciplinary cross-border integration, the present work explored a new way for the creation of modern Chinese medicine.

Preparation and activity study of monolithic three-dimensional ordered macroporous La0.7Ce0.3CoO3 with different loading methods

The innovative mixed impregnation method was used to realize the combination of polymethylmethacrylate(PMMA) template, active components and cordierite carrier in the preparation of monolithic catalyst. Compared with the samples prepared by centrifugal deposition method and deposition curing method, three-dimensional ordered macroporous(3DOM) La0.7Ce0.3CoO3 cordierite catalysts prepared by mixed impregnation method have obvious advantages over other samples in morphology, microstructure, surface properties and redox capacity. Through a series of characterization, it was found that the active components of the catalyst prepared by mixed impregnation method(3DOM La0.7Ce0.3CoO3/MIM) were highly dispersed on the surface of cordierite carrier, and the most complete La0.7Ce0.3CoO3 perovskite crystal structure was formed. At the same time, 3DOM La0.7Ce0.3CoO3/MIM formed a macroporous-mesoporous structure, which provided a good diffusion environment for the reactants. In addition, catalysts prepared by mixed impregnation method had excellent catalytic activity (T50 = 103 ℃, T90 = 218 ℃) and good stability due to its large specific surface area (10.57 m2/g), high Oads/Olatt concentration and good redox ability. The apparent activation energy of 3DOM La0.7Ce0.3CoO3/MIM was 59.56 kJ·mol−1, which was lower than that of catalysts prepared by centrifugal deposition method (72.07 kJ·mol−1) and deposition curing method (71.38 kJ·mol−1). It can be concluded that the high activity of 3DOM La0.7Ce0.3CoO3/MIM can be attributed to the high dispersion of active components, permeable pore structure, high surface adsorbed oxygen concentration and good low temperature reduction.

Cardiac electro-mechanical activity in a deforming human cardiac tissue: modeling, existence-uniqueness, finite element computation and application to multiple ischemic disease.

In this study, the cardiac electro-mechanical model in a deforming domain is taken with the addition of mechanical feedback and stretch-activated channel current coupled with the ten Tusscher human ventricular cell level model that results in a coupled PDE-ODE system. The existence and uniqueness of such a coupled system in a deforming domain is proved. At first, the existence of a solution is proved in the deformed domain. The local existence of the solution is proved using the regularization and the Faedo-Galerkin technique. Then, the global existence is proved using the energy estimates in appropriate Banach spaces, Gronwall lemma, and the compactness procedure. The existence of the solution in an undeformed domain is proved using the lower semi-continuity of the norms. Uniqueness is proved using Young's inequality, Gronwall lemma, and the Cauchy-Schwartz inequality. For the application purpose, this model is applied to understand the electro-mechanical activity in ischemic cardiac tissue. It also takes care of the development of active tension, conductive, convective, and ionic feedback. The Second Piola-Kirchoff stress tensor arising in Lagrangian mapping between reference and moving frames is taken as a combination of active, passive, and volumetric components. We investigated the effect of varying strength of hyperkalemia and hypoxia, in the ischemic subregions of human cardiac tissue with local multiple ischemic subregions, on the electro-mechanical activity of healthy and ischemic zones. This system is solved numerically using the [Formula: see text] finite element method in space and the implicit-explicit Euler method in time. Discontinuities arising with the modeled multiple ischemic regions are treated to the desired order of accuracy by a simple regularization technique using the interpolating polynomials. We examined the cardiac electro-mechanical activity for several cases in multiple hyperkalemic and hypoxic human cardiac tissue. We concluded that local multiple ischemic subregions severely affect the cardiac electro-mechanical activity more, in terms of action potential (v) and mechanical parameters, intracellular calcium ion concentration [Formula: see text], active tension ([Formula: see text]), stretch ([Formula: see text]) and stretch rate ([Formula: see text]), of a healthy cell in its vicinity, compared to a single Hyperkalemic or Hypoxic subregion. The four moderate hypoxically generated ischemic subregions affect the waveform of the stretch along the fiber and the stretch rate more than a single severe ischemic subregion.

Combination of mulberry leaf active components possessed synergetic effect on SD rats with diabetic nephropathy by mediating metabolism, Wnt/β-catenin and TGF-β/Smads signaling pathway

Ethnopharmacological relevanceMulberry leaf has attracted much attention due to its excellent curative effect on diabetes and its complications, whether the combination of its effective components have protective and synergistic effect on diabetic nephropathy (DN) in vivo remain unclear. Aim of the studyThe aim of this study was to investigate the protective and synergistic effect of the combination (MAF1:1 and MAF1:5) of mulberry leaf alkaloids (MA) and flavonoids extract (MF) on DN. Materials and methodsA step by step method consisted of network pharmacological prediction, animal in vivo validation and metabolic mechanism research was used to construct the multi-component-target-pathway network of mulberry leaf against DN. Firstly, the potential components and mechanism of mulberry leaf against DN was explored by network pharmacology analysis. Secondly, DN animal model was established to validate the anti-DN activity of these potential compounds. Thirdly, the metabolomics of serum and urine samples from animal experiments was analyzed to explore the anti-DN mechanism of these potential compounds. ResultsThe results of network pharmacology demonstrated that a total of 7 compounds detected in MA and MF exhibited anti-DN activity, their mechanism were strongly in connection with metabolic pathways, arachidonic acid metabolism, sphingolipid signaling pathway, etc. The results of animal experiment indicated that MAF1:1 and MAF1:5 significantly relieved metabolic disorders through regulating Wnt/β-catenin and TGF-β/Smads signaling pathway, just like MF or MA alone. Metabolomics suggested they could regulate 16 serum and 7 urine endogenous metabolites through arachidonic acid metabolism, phenylalanine metabolism and sphingolipid metabolism, thus alleviated DN. Significantly, MAF1:1 and MAF1:5 might possess synergistic effect considering their therapeutic effects on DN rats were superior to the single use of MA or MF. ConclusionsMAF1:1 and MAF1:5 possessed protective and synergistic effect on DN rats through multi-target and multi-pathways. These findings were of great scientific significance and application value to reveal the advantage of mulberry leaf in preventing and treating DN.

An integrated approach to reducing hyperesthesia of teeth in patients with underlying somatic pathology

Was to analyze the effectiveness of therapeutic and preventive measures aimed at reducing hyperesthesia of hard dental tissues in patients with background somatic diseases. The study involved 113 patients with increased tooth sensitivity and treated in the gastroenterological and endocrinological departments of the S.M. Kirov City Clinical Hospital No.3» in Astrakhan in the period from 2018 to 2021 at the age of 26-43 years. The main group included 52 patients with confirmed diagnoses of gastric and duodenal ulcer, pancreatitis and type II diabetes mellitus who were treated for dental hyperesthesia with an integrated approach. The control group included 61 patients with periodontal disease without background somatic pathologies in whom hyperesthesia was treated by remineralizing therapy. The effectiveness of the treatment was determined in dynamics on the 10th and 40th days of treatment using OHI-S, PMA indices, dental hypersensitivity prevalence (DHP), dental hypersensitivity intensity (DHI), Dental Sensitivity Index (DSI), Efficacy of Dental Sensitivity Index (EDSI). In addition, the pH of saliva, the activity of lysozyme and S-IgA, and the levels of cytokines IL-1β, IL-4, IL-6, and IL-8 were determined. The average value of OHI-S in the main group on the 10th day of treatment decreased from 2.25±0.12 (poor level of hygiene) to 1.47±0.09 (satisfactory level). The PMA index in the main group also tended to decrease from 32.1±1.44% (moderate degree of gingivitis) to 20.5±2.08% (mild degree) on the 10th day of treatment. The average values of DPH, DPI, EDSI and DSI in the main group had a noticeable decrease already on the 10th day from the start of treatment (from 12.3±1.66% to 2.1±1.22%; from 2.5±0.48 to 1.2±0.16; from 48.3±1.14% to 40.8±1.71%; from 42.1±2.07% to 20.8±1, 65% respectively). In the main group on the 10th and 40th day of treatment the pH values of non-stimulated and stimulated saliva stabilized (from 4.61±0.12 to 6.94±0.07 and from 5.47±0.21 to 7.42±0.24, respectively), the activity of lysozyme increased (from 45.97±1.46% to 55.19±0.96%) alongside with secretory IgA (from 0.17±0.02 to 0.33±0.21 mg/ml). Also, indicators of cytokines IL-1β, IL-4, IL-6, IL-8 tended to improve. The analysis of the control group revealed persistent mean values that did not yield to significant changes either in the course of treatment. Thus, in patients of the main group, the results obtained indicate an improvement in the dental status and activation of cytokine regulation, providing a combination of active components of the mineral complex. In controls the method of remineralizing therapy for tooth hyperesthesia alleviated dental hypersensitivity, but without significant improvement of the laboratory results.

An insight of CO 2 hydrogenation to methanol synthesis: Thermodynamics, catalysts, operating parameters, and reaction mechanism

Catalytic hydrogenation of CO2 to methanol is an exciting avenue to curb the rising CO2 emissions and generate renewable energy or value-added products. Methanol synthesis via the thermal catalysis route gets increasing emphasis due to its fast kinetics and flexible combination of active components. In the last decade, many studies on CO2 hydrogenation to methanol have been reported with different kinds of catalysts that have been synthesized and characterized using state-of-the-art surface science tools and techniques. In situ analysis techniques as well as theoretical (eg, density functional theory, Monte Carlo simulations, and Micro-Kinetics modeling) studies have been performed to understand the insights of morphology changes, the interaction of active sites, and the formation of intermediate species under the reaction conditions. In the present review, the advancements on CO2 to methanol via hydrogenation route have been presented taking into consideration different perspectives spanning across thermodynamic aspects, the influence of reaction temperature, pressure, feed composition, space-velocity, and morphologically tuned novel catalyst on CO2 conversion and methanol selectivity. Among the reported catalysts, the Al2O3-supported Cu-Zn catalyst showed better performance with 25% CO2 conversion and 73% methanol selectivity at 170°C and 50 bar pressure. The CeO2-supported Pd-Zn catalyst showed 14% CO2 conversion and 97% methanol selectivity at 220°C under 20 bar pressure. Also, CeO2-nanorods supported Cu-Ni catalyst showed good performance at 260°C and 30 bars, with around 18% CO2 conversion and 73% methanol selectivity. Additionally, the mechanistic insights of the process are emphasized with necessary figures and diagrams. The rate-determining steps for each mechanism are also highlighted with chemical structures for further clarity. This review also summarizes potential catalysts and their optimum operating conditions to achieve maximum CO2 conversion and methanol selectivity. We believe, the review is unique and not found in any article which addressed the above aspects altogether in a compact form.

Active syndromic surveillance of COVID-19 in Israel

Syndromic surveillance systems monitor disease indicators to detect emergence of diseases and track their progression. Here, we report on a rapidly deployed active syndromic surveillance system for tracking COVID-19 in Israel. The system was a novel combination of active and passive components: Ads were shown to people searching for COVID-19 symptoms on the Google search engine. Those who clicked on the ads were referred to a chat bot which helped them decide whether they needed urgent medical care. Through its conversion optimization mechanism, the ad system was guided to focus on those people who required such care. Over 6 months, the ads were shown approximately 214,000 times and clicked on 12,000 times, and 722 people were informed they needed urgent care. Click rates on ads and the fraction of people deemed to require urgent care were correlated with the hospitalization rate (R^2=0.54 and R^2=0.50, respectively) with a lead time of 9 days. Males and younger people were more likely to use the system, and younger people were more likely to be determined to require urgent care (slope: - ,0.009, P=0.01). Thus, the system can assist in predicting case numbers and hospital load at a significant lead time and, simultaneously, help people determine if they need medical care.

Main Active Components and Cell Cycle Regulation Mechanism of Astragali Radix and Angelicae Sinensis Radix in the Treatment of Ox-LDL-Induced HUVECs Injury and Inhibition of Their Cell Cycle.

To explore the main active components and effects of cell cycle regulation mechanism of Astragali radix (AR) and Angelicae sinensis radix (ASR) on oxidative damage in vascular endothelial cells, a model of oxidative damage in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (ox-LDL) treatment was developed. Based on the “knock-out/knock-in” model of the target component, cell viability, intracellular reactive oxygen species (ROS), and lactate dehydrogenase (LDH) leakage were assessed by Cell Counting Kit-8 assay, fluorescent probe 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA), and colorimetric assay, respectively, to evaluate the protective effect of the active components of AR and ASR (astragaloside IV (AS IV), astragaloside I (AS I), formononetin (FRM), calycosin (CAL), calycosin-7-O-β-D glucoside (CLG), and ferulic acid (FRA)) against oxidative damage. The cell cycle and expression of genes encoding cyclins and cyclin-dependent kinases (CDKs) were observed using flow cytometry and quantitative real-time polymerase chain reaction. The results showed that the combination of active components (ACC) significantly inhibited the decrease in cell viability as well as the increase in ROS and LDH release in HUVECs induced by ox-LDL treatment. AS IV and FRM promoted the proliferation of HUVECs but the proliferation index was decreased in the AS I and FRA groups; this inhibitory effect was counteracted by the ACC. The ACC reduced and increased the proportion of positive cells in G1 and S phases, respectively, followed by the upregulation of cyclin A (CCNA), cyclin E (CCNE), and CDK2 mRNA expression and downregulation of cyclin B (CCNB), cyclin D1 (CCND1), CDK1, CDK4, and CDK6 mRNA expression, which significantly mitigated inhibition of HUVECs proliferation induced by ox-LDL treatment. Taken together, AS IV, AS I, FRM, CAL, CLG, and FRA were the primary pharmacodynamic substances of AR and ASR that alleviated oxidative injury in HUVECs. ACC mitigated the upregulation of intracellular ROS levels and LDH release induced by ox-LDL treatment, which promoted the cell cycle procession of HUVECs by regulating the expression of genes encoding cyclins and CDKs and thus preventing oxidative damage in HUVECs.

Cryogenic electro-optic polarisation conversion in titanium in-diffused lithium niobate waveguides.

Many technologies in quantum photonics require cryogenic conditions to operate. However, the underlying platform behind active components such as switches, modulators and phase shifters must be compatible with these operating conditions. To address this, we demonstrate an electro-optic polarisation converter for 1550 nm light at 0.8 K in titanium in-diffused lithium niobate waveguides. To do so, we exploit the electro-optic properties of lithium niobate to convert between orthogonal polarisation modes with a fiber-to-fiber transmission >43%. We achieve a modulation depth of 23.6±3.3 dB and a conversion voltage-length product of 28.8 V cm. This enables the combination of cryogenic photonics and active components on a single integration platform.

Hot Times in Tectonophysics: Mantle Plume Dynamics and Magmatic Perturbances

Earth’s dynamic lithospheric (plate) motions often are not obvious when considered in relation to the temporal stability of the crust. Seismic radiology experiments confirm that the extreme pressures and temperatures in the mantle, and to a lesser extent the asthenosphere, result in a heterogeneously viscous rheology. Occasionally, magmatic fluid makes its way through the lithospheric plate to the surface, appearing typically as a volcano, fissure eruption, or lava flow. When occurring away from the edges of plate boundaries, these long-lasting suppliers of lava, present over millions of years, are called mantle plumes, or ‘hotspots.’ Conventional definitions of mantle plumes note that they are stationary with respect to each other and the motion of the plates, passively tracing historical plate motion in volcanic formations such as the Hawaiian-Emperor island arc – the Plate Model. In this model, mantle plumes primarily occur as a consequence of lithospheric extension.Recent empirical studies, however, have demonstrated that hotspots are not as geographically consistent as previously thought. They may move in relation to each other, as well as contribute actively toward lithospheric plate motions – the Plume Model. There is a lively, ongoing debate between the Plate and Plume hypotheses, essentially seeking to determine if mantle flow is merely a passive reaction to lithospheric plate motion (Plate Model), or whether plume activity in part drives this motion (Plume Model). More likely, it is a combination of passive and active mantle plume components that better describe the comprehensive behavior of these important and distinctive landscape forming features.

Bi2S3–CoS@C core- shell structure derived from ZIF-67 as anodes for high performance lithium-ion batteries

The combination of multiple active components and engineering of reasonable structures are effective strategies to prepare high-performance electrochemical electrodes. Herein, a specially designed Bi2S3–CoS@C core-shell structure is synthesized using ZIF-67 as a template, in which nanoparticles of Bi2S3 and CoS in the composites are surrounded by a carbon layer with a sufficient amount of hollow space. This structure is conducive to the transport of ions, an increase in the conductivity and accommodating the volume change of the active materials during cycling. When applied as an anode for lithium-ion batteries, the Bi2S3–CoS@C electrode exhibits excellent electrochemical properties, displaying an excellent specific capacity of 1390 mAh g−1 at a current density of 100 mA g−1 after 100 cycles. During a long cycling test, an excellent reversible capacity of 836.2 mAh g−1 can also be obtained at a high current density of 1 A g−1 after 300 cycles. This work sheds light on an efficient approach to build novel high-performance electrodes for energy devices.

GAPT regulates cholinergic dysfunction and oxidative stress in the brains of learning and memory impairment mice induced by scopolamine

BackgroundCholinergic dysfunction and oxidative stress are the crucial mechanisms of Alzheimer's disease (AD). GAPT, also called GEPT (a combination of several active components extracted from the Chinese herbs ginseng, epimedium, polygala and tuber curcumae) or Jinsiwei, is a patented Chinese herbal compound, has been clinically widely used to improve learning and memory impairment, but whether it can play a neuroprotective role by protecting cholinergic neurons and reducing oxidative stress injury remains unclear.MethodsMale ICR mice were intraperitoneally injected with scopolamine (3 mg/kg) to establish a learning and memory disordered model. An LC‐MS method was established to study the chemical compounds and in vivo metabolites of GAPT. After scopolamine injection, a step‐down passive‐avoidance test (SDPA) and a Y maze test were used to estimate learning ability and cognitive function. In addition, ELISA detected the enzymatic activities of acetylcholinesterase (AChE), acetylcholine (ACh), choline acetyltransferase (ChAT), malondialdehyde (MDA), glutathione peroxidase (GPX), and total superoxide dismutase (T‐SOD). The protein expressions of AChE, ChAT, SOD1, and GPX1 were observed by western blot, and the distribution of ChAT, SOD1, and GPX1 was observed by immunohistochemical staining.ResultsAfter one‐half or 1 month of intragastric administration, GAPT can ameliorate scopolamine‐induced behavioral changes in learning and memory impaired mice. It can also decrease the activity of MDA and protein expression level of AChE, increase the activity of Ach, and increase activity and protein expression level of ChAT, SOD, and GPX in scopolamine‐treated mice. After one and a half month of intragastric administration of GAPT, echinacoside, salvianolic acid A, ginsenoside Rb1, ginsenoside Rg2, pachymic acid, and beta asarone could be absorbed into mice blood and pass through BBB.ConclusionsGAPT can improve the learning and memory ability of scopolamine‐induced mice, and its mechanism may be related to protecting cholinergic neurons and reducing oxidative stress injury.

Thermal design and on-orbit performance of the ECOSTRESS instrument

The ECOSystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) instrument, launched on June 29, 2018, has completed nine months of operation in space. ECOSTRESS is a multi-spectral thermal infrared imaging radiometer and its primary mission is to investigate and understand how climate change affects water and carbon usage on Earth. The thermal control subsystem consists of a combination of active and passive components to maintain instrument components within the allowable flight temperature limits. Its focal plane detector is cooled to 65K by a pair of mechanical cryocoolers and a third mechanical cryocooler cools an intermediate cold shield to 130K. The heat dissipation generated by cryocoolers and electronics, is removed through non-planar cold plates and tube-on plate heat exchanger, which are cooled by a circulating fluid loop inside JAXA’s JEM-EF module. The heat collected by the JEM-EF fluid is exchanged with a fluid loop that circulates through radiators located on the exterior of the Space Station. This paper provides an overview of the thermal and cryogenic system design, thermal analysis results and reviews the on-orbit thermal performance.

The use of multicomponent ear drops in the treatment of otitis of various etiologies in animals.

Objective:The objective of this study was to investigate the efficacy of newly developed multicomponent ear drops for the treatment of otitis caused by parasites, bacteria, and fungi in dogs, cats, ferrets, fancy rabbits, and foxes.Materials and Methods:A new drug for veterinary use was developed that contained levofloxacin hemihydrate (0.3%), clotrimazole (0.1%), dexamethasone sodium phosphate (0.1%), and moxidectin (0.01%). In the initial stage of otoacariasis (or the ear form of psoroptic scab), the drug was used twice with an interval of 5–7 days. When otoacariasis (psoroptic scab) was complicated by otitis of bacterial and/or fungal etiology, the drug was used as follows: instilled once a day, within 10–14 days in the ear canal for 2–5 drops of the drug. The study of therapeutic efficacy was performed on cats, dogs, ferrets, foxes, and fancy rabbits with ear pathology.Results:The recovery of cats, ferrets, dogs, and foxes after the double use of ear drops during otoacariasis was established. In the ear form of psoroptic scab in fancy rabbits after treatment, Psoroptes cuniculi mites were not detected. The specific (antimicrobial and antifungal) activity of the drug was confirmed in vivo using the following scheme of drug use: the drug was instilled once a day, within 10–14 days in the ear canal, 2–5 drops of the drug in animals with external otitis and otitis media.Conclusion:The rational combination of active components developed in this study is effective and safe for use in animals with microbial diseases of the ears.

Use of various drugs based on herbal components in complex treatment of inflammatory periodontal diseases

The article discusses the use of various dosage forms of anti-inflammatory periodontal drugs used in patients with inflammatory periodontal diseases. The rapid anti-inflammatory efficacy of toothpaste, gel, aerosol, and rinse aid has been proven. The combination of several active components in one product actively affects all parts of the pathogenesis of the inflammatory process from antimicrobial effects to the elimination of halitosis.

The catalytic performance enhancement of Ni2P electrocatalysts for hydrogen evolution reaction by carbon-based substrates

Combination of catalytic active components with substrates is deemed to be a promising approach to pursue high active and stable catalysts. Wherein, carbon-based materials as a kind of frequently-used substrates are well developed, and thus the different effects of them on catalytic active components deserve investigating and contrasting. In this work, well dispersive and ultrafine Ni2P nanoparticles supported on N-doped reduced graphene oxide (N-RGO) were synthesized through a facial hydrothermal process and subsequent phosphorization. The prepared Ni2P/N-RGO demonstrates a superior electrocatalytic activity towards hydrogen evolution reaction (HER) in 0.5 M H2SO4 solution with a low onset overpotential (80 mV) and small Tafel slope (93.1 mV dec−1). Additionally, as compared with other representative carbon materials (carbon black (C) and carbon nanotubes (CNTs)) in the perspective of specific surface area (SSA), conductivity and electronic interaction in particular, N-RGO demonstrates a preeminent promotional effect as a substrate of Ni2P.