Color Patches Research Articles

Natural and sexual selection and functional roles influence colouration but not the amount of variation in butterfly wing colour patterns

BackgroundTrait variation is shaped by functional roles of traits and the strength and direction of selection acting on the traits. We hypothesized that in butterflies, sexually selected colouration is more variable owing to condition-dependent nature and directional selection on sexual ornaments, whereas naturally selected colouration may be less variable because of stabilising selection. We measured reflectance spectra, and extracted colour parameters, to compare the amount of variation in sexually versus naturally selected colour patches across wing surfaces and sexes of 20 butterfly species across 4 families (Nymphalidae, Papilionidae, Pieridae, Lycaenidae).ResultsWe found that: (a) males had more conspicuous, i.e., brighter and more saturated colour patches compared with females (as expected of sexually selected traits but not necessarily of naturally selected traits), and (b) dorsal surfaces in both sexes had more conspicuous sexual ornaments as well as protective (aposematic/mimetic) colour patches on darker wing backgrounds, compared with ventral surfaces. However, colour patches did not differ in the amount of variation either in selection (ecological/sexual functions), sex or wing surface-specific manner.ConclusionsThese findings show that functional roles and selection influence colour parameters but not the amount of variation in butterfly wing colour patterns.

Experimental Protocol for Color Difference Evaluation Under Stabilized LED Light.

There are two key factors to consider before implementing a color discrimination experiment. First, a set of color patches should be selected or designed for the specific purpose of the experiment to be carried out. Second, the lighting conditions should be controlled to eliminate the impact of lighting instability on the experiment. This paper addresses both of these challenges. It proposes a method to print pairs of color patches with non-noticeable color differences. It also proposes a method to stabilize the Spectral Power Distributions (SPDs) of a Light-Emitting Diode (LED) lighting system. Finally, it introduces an experimental protocol for a color discrimination study that will be performed thanks to the contributions presented in this paper.

Averaging illumination colors of multi-illumination ensembles

Average extraction from multiple similar items in ensemble perception has been demonstrated in a variety of visual features. This study investigated whether the visual system can extract precisely the average illumination color from multi-illumination ensembles. In a two-interval forced choice (2IFC) task of the constant stimulus method, observers were asked to judge whether the color of four identical test illuminations (homogeneous condition) or the average color of four distinct test illuminations (heterogeneous condition) was yellower than the reference illumination D67. Four types of scenes were used: Munsell surfaces only, Munsell surfaces with dark and light gray intervals, respectively, and an image of color patches on a white background. The mean values of the cumulative normal distribution functions fitted to the data under the heterogeneous condition were close to those under the homogeneous condition, indicating that the observer has the ability to precisely extract the average illumination color from a set of illuminations. This suggests that rapid and efficient averaging can also be performed in the high-level illumination estimation task.

Complex application of СО2 laser and tranexamic acid in the treatment of melasma in postmenopausal women (literature review)

Melasma is a common acquired pigmentation disorder, represented by patches of light brown or brown color localized on areas of the skin exposed to prolonged sunlight. The increased activity of melanocytes, which underlies the pathogenesis of melasma, is due to genetic predisposition, chronic insolation and hormonal imbalance. In postmenopausal women, the increased severity of melasma is associated with a combination of these factors. In addition, pigmentation disorders may be affected by taking certain medications and other environmental factors. There are many methods of treating melasma, including the use of topical remedies, chemical peels, laser therapy and others. In recent years, more and more attention has been paid to an integrated approach that combines various treatment methods to achieve the best result. One of the effective methods of treating this pathology is the use of a CO2 laser. However, many patients relapse after laser treatment. In this regard, there has been interest in the combined use of laser therapy using topical agents that reduce the severity of pigmentation. One of these drugs is tranexamic acid, which has the property of reducing the activity of melanocytes.The purpose of this literature review is to study the latest publications on the treatment of melasma using laser-associated administration of tranexamic acid.Material and methods. The literature data on search words – melasma, hyperpigmentation, tranexamic acid, CO2 laser, fractional grinding, laser-associated administration, postmenopause in computer databases PubMed, Elibrary, Cochrane Library, Medscape were studied. Web of Science, Scopus. Publications included basic scientific research, randomized controlled trials, comments and reviews. The results of clinical improvement were assessed by the MASI melasma area and severity index, as well as the modified mMASI index.

Rapid source forgetting across modalities: A problem for working memory models.

Working memory is a cognitive system that enables the temporary retention (usually a few seconds) of a limited amount of information. However, recent evidence has posed challenges to the conventional understanding of working memory's persistence. Chen et al. (Psychological Science, 29(4), 645-655, 2018) demonstrated that participants can easily make judgments using a stimulus's identity but cannot recall from which source the information came (presented either as a written word or a color patch) just milliseconds earlier. This "Source Amnesia" carries substantial implications for working memory models but has yet to be explored within the realm of verbal information. We fill this gap by investigating the robustness and generalizability of this rapid forgetting phenomenon. We first replicate the observed effect within the visual domain (Experiment 1) and subsequently extend it to the verbal domain (Experiment 2). Finally, we test the idea that participants may instead encode a positional context (Experiment 3), in line with the Interference model (Oberauer & Lin, Psychological Review, 124(1), 21, 2017). Aligning with the work of Chen et al. (Psychological Science, 29(4), 645-655,2018), our results consistently reveal a pronounced tendency for rapid forgetting, for both visual and verbal information regardless of whether the information is elicited for recall by format or position cues. The theoretical implications of these findings for current memory models are discussed.

Explicit and Implicit Preference for Symmetry Across Object Categories

Symmetry affects aesthetic judgements, and it has been extensively studied at least for faces and abstract objects. We examined the role of bilateral symmetry on aesthetic judgements across different types of stimuli. It is important to test if symmetry is equally effective in the context of objects expected to be symmetrical, e.g., faces, and objects that are almost never symmetrical, e.g., landscapes. We used the following categories: angular shapes, smooth shapes, landscapes, flowers, female faces, and male faces. We selected these image categories considering their differing degrees of curvature, familiarity to the viewer, and tendency to be perceived as ensembles, as opposed to standalone objects. We also included blobs, manipulating landscapes into blurry tessellated patterns featuring patches of color, to remove familiarity while preserving the appearance of ensembles. For each item in these categories, images were modified to obtain perfect bilateral symmetry. We collected both explicit ratings and implicit measures of symmetry preference. For landscapes, there was a clear preference for the non-symmetrical (original) version. We observed a dissociation between explicit and implicit measures. Implicit measures demonstrated positive associations for all categories.

Object color knowledge representation occurs in the macaque brain despite the absence of a developed language system.

Animals guide their behaviors through internal representations of the world in the brain. We aimed to understand how the macaque brain stores such general world knowledge, focusing on object color knowledge. Three functional magnetic resonance imaging (fMRI) experiments were conducted in macaque monkeys: viewing chromatic and achromatic gratings, viewing grayscale images of their familiar fruits and vegetables (e.g., grayscale strawberry), and viewing true- and false-colored objects (e.g., red strawberry and green strawberry). We observed robust object knowledge representations in the color patches, especially the one located around TEO: the activity patterns could classify grayscale pictures of objects based on their memory color and response patterns in these regions could translate between chromatic grating viewing and grayscale object viewing (e.g., red grating-grayscale images of strawberry), such that classifiers trained by viewing chromatic gratings could successfully classify grayscale object images according to their memory colors. Our results showed direct positive evidence of object color memory in macaque monkeys. These results indicate the perceptually grounded knowledge representation as a conservative memory mechanism and open a new avenue to study this particular (semantic) memory representation with macaque models.

Formulation and Characteristics of Hydrogel Patch Containing Pineapple Peel (Ananas comosus L.) Ethanol Extract

Abstract Pineapple peel (Ananas comosus L.) contains bioactive compounds such as flavonoids and the enzyme bromelain, which possess antioxidant, anti-inflammatory, antibacterial, and anticancer properties, and the ability to accelerate wound healing. Hydrogel patches, as a formulation for transdermal delivery, are effective in wound healing due to their hydrophilic properties that maintain moisture and prevent bacterial infection in open wounds. This study aims to develop and test the characteristics of hydrogel patch formulations containing ethanol extracts of pineapple peel with varying concentrations of 10%, 20%, and 30%, compared to a control (hydrogel patch without pineapple peel extract). A series of evaluation tests were conducted to assess the patch characteristics, including organoleptic tests, pH, absorbency, weight uniformity, swelling ratio, patch thickness, and folding endurance. The results showed that the concentration of pineapple peel extract affects the hydrogel patch characteristics. The higher the extract concentration, the darker the patch color, but the pH, absorbency, and swelling ratio decrease. Patches with higher extract concentrations also showed an increase in weight. Absorbency tests indicated that none of the formulas met the acceptance criteria (<10%), with absorbency results of 22.97%, 11.60%, and 21.95% for 10%, 20%, and 30% extract concentrations, respectively, and 23.43% for the control. Swelling ratio and thickness tests showed the best results for the control, followed by the 10%, 20%, and 30% extract concentrations. The folding endurance test showed that the control and 10% extract formula had good results (>300 folds), while higher extract concentrations reduced the folding endurance of the hydrogel patch .Keywords: extract, pineapple peel, hydrogel patch, formulation, patch characteristics

Color–emotion associations by speakers of Spanish and Mandarin in verbal and visual tasks: a comparison

Abstract This study aims to determine if there are differences in color–emotion association between monolingual speakers of Spanish and Mandarin, depending on how colors are presented (verbally or visually). We tested two groups of 25 speakers of these two languages in two different tasks using the Geneva Emotion Wheel, which encompasses 20 types of emotions. In Task 1, 13 colors were presented to participants as color terms in their native language, whereas in Task 2 the same colors were presented as color patches from the Munsell chart. Participants were then asked to associate color terms or color patches to the set of emotion concepts (and intensities of emotion) in the Geneva Emotion Wheel. Overall, differences between languages were not significant, regarding either the type of emotion or individual dimensions of emotion (valence, arousal or power), although significant differences were observed for specific colors. Also, Spanish speakers tended to attribute higher intensity values and higher numbers of emotion values to colors. At the same time, speakers of both languages reacted similarly to color presentation, with color terms being associated with the same emotions as color patches, but eliciting stronger reactions with respect to intensity and the number of emotion values. Finally, we found less variability in color–emotion associations within the Spanish-speaking group. Overall, our study points to a mixed pattern of universality and culture-specificity regarding how colors are used for conveying emotions by people.

Dermoscopic Features of Cutaneous Hypopigmented Lesions

Abstract Background Pigmentation disorders are rather common in dark skin. In India, 11% of patients presenting to the dermatology outpatient department in Western India have pigmentary disorders. Recently, dermoscopy has been involved as an important tool in the diagnosis of various dermatological diseases. Aim of the Work The aim of this study was to describe the Dermoscopic features of some hypopigmented skin disorders that may be clinically overlapping in order to facilitate differentiation between these skin disorders. Patients and Methods This Cross section descriptive study included 104 patients who complained of patchy or macular hypopigmented lesions. Results The most common dermoscopic features of progressive vitiligo were; Perifollicular hyperpigmentation, diffuse white glowing areas, white vellus and terminal hairs. The most common dermoscopic features of repigmenting vitiligo were; perifollicular pigmentation, marginal hyperpigmentation and interfollicular pigmentation. The most common dermoscopic features of stable vitiligo were; starburst appearance and altered pigmentation, marginal hyperpigmentation and perifollicular pigmentation. The most common dermoscopic features of idiopathic guttate hypomelanosis were; multiple, shiny and porceilin like macules, most of the lesions were well- defined (amoeboid pattern), few lesions were ill-defined with irregular cloudy whitish pattern (nebuloid pattern) and hyperpigmented networks were seen on the surrounding skin of some lesions giving the appearance of the cloudy-sky pattern. The most common Dermoscopic features of nevus depigmentosus were; hypopigmented patch with irregular and serrated borders, faint reticular network in some patches, borders showed pseudopods pattern protruding into the normal skin, the surrounding skin was scaly on some lesions and hair was pigmented with no peri-follicular hyperpigmentation. The most common dermoscopic features of pityriasis alba were; fairly demarcated hypopigmented macules, fine scales and hair inside patches of normal color. Conclusion Dermoscopy can aid in the diagnosis of hypopigmented skin disorders and can help in assessing the activity of vitiligo, however in sometimes the condition may be challenging and difficult to differentiate even by dermoscopy and in such cases histopathological examination may be helpful.

Flash behaviors protect prey from avian predators

Abstract It has been proposed that flash behaviors, defined as the transient display of conspicuous color patches during escape, serve as an anti-predator defense in camouflaged prey. While recent studies in humans have demonstrated the effectiveness of flash behaviors in improving the survival of artificial prey, it remains unclear whether these benefits also arise in more natural systems involving non-human predators. This study investigated the adaptive significance of flash behaviors using chicks (Gallus gallus domesticus) as predators and virtual prey. Our experiments revealed that prey employing flash behaviors consistently enhanced their survival rate compared to non-flashing prey. Additionally, prey with non-conspicuous escape colors, though distinct from their resting colors, also showed a higher survival rate than non-flashing prey, challenging the conventional belief that conspicuous colors are required for search interference. An interplay between prey size and flash behaviors in enhancing survival was evident, with larger prey benefiting more than smaller prey. We found no evidence to suggest that being hidden before initiating an escape confers a survival advantage to flashing prey compared to being visible before escape. This study sheds light on the adaptive benefits of flash behaviors against natural predators and contributes to our understanding of the widespread occurrence of hidden color signals in camouflaged prey. We encourage further studies to explore the effectiveness of remaining hidden in flashing prey when confronted with natural predators, as well as how predators might learn to overcome the deception of flash behaviors.

Divergent ornamentation within a single population of the barn swallow.

Differential migration strategies favour different sets of characteristics, including sexually selected ornamentation. Such phenotypic variation is particularly evident in a population with partial migration, where migrants and nonmigrants co-exist. Partial migration provides insights into the link among migration, local environment, and ornamentation, although empirical studies remain scarce. Here, we studied the plumage traits of barn swallows (Hirundo rustica) in southern Japan, where both winterings and migrants breed sympatrically. We further examined this relationship with multiple isotopes (δ2H, δ13C, δ15N, and δ34S), which provides insight into their moulting habitat. Among males, winterings and migrants differed in their morphological traits: wintering males had shorter wings, which suggests the high demand for flight apparatus in migratory birds. Moreover, wintering males had larger white tail spots and less colourful throat patches than migratory males, indicating ornament divergence between them. Wintering males had a significantly smaller isotopic space when examining the combinations of δ34S with the other isotopes compared to migratory males, which indicates a differential geographic range between them, perhaps because of the limited variation in the distance to the sea in wintering males. As in males, wintering females had a significantly smaller isotopic space than migrant females, but there were few morphological differences between migratory and wintering females. Instead, some morphological traits were related to isotope values in females. These results indicate sex-specific linkage among migration, local environment, and ornamentation.

Ecological, genetic and geographical divergence explain differences in colouration among sunbird species (Nectariniidae).

How extravagant ornamental traits evolve is a key question in evolutionary biology. Bird plumages are among the most elaborate ornaments, displaying almost all colours of the rainbow. Why and how birds evolved to be so colourful remains an open question with multiple and sometimes competing hypotheses. Different colours in different patches (i.e. body parts) might have different functions and thus result from different forms of selection (e.g. natural vs. sexual selection). Here we test the influence of three factors on colour diversity in sunbirds: (1) geographical distance, (2) differences in light environment and (3) phylogenetic distances. We show that both natural and sexual selection affect the evolution of sunbird colouration, but that their extent and direction differs between sexes, and varies with the extent of species overlap and across different patches on the body. Even though overlap in light environment partially explains colour differences among species, no colour metric (brightness, hue or chroma) covaries with light environment. Our results suggest that multiple forms of selection influence the colouration of different colour patches in different ways across an organism's body, highlighting the need to investigate colouration as a network of individual but inter-connected colour patches. These results are likely to be generalizable across the multitude of colourful animals.

Pattern Matters in the Aposematic Colouration of Papilio polytes Butterflies.

Many toxic animals display bright colour patterns to warn predators about their toxicity. This sometimes leads other sympatric palatable organisms to evolve mimetic colour patterns to also evade predation. These mimics, however, are often imperfect, and it is unclear how much their colour patterns can vary away from the model before they become ineffective. In this study, we investigated how predation risk of the palatable Common Mormon butterfly (Papilio polytes) is affected by two alterations of its wing pattern that make it progressively more distinct from its model, the Common Rose (Pachliopta aristolochiae). We deployed butterfly paper models in the field, where all models displayed the same colours but had different patterns. In the first modification from the Wildtype pattern, we exchanged the position of the red and white colour patches but kept the overall pattern constant. In the second modification, we created an eyespot-like shape from the pre-existing pattern elements by moving their positions in the wing, altering the overall wing pattern. Both modifications increased attack risk from predators relative to Wildtype patterns, with the eyespot-like modification having the highest predation risk. Our results show that avian predators can distinguish between all three patterns tested, and that pattern is important in aposematic signals. Predators learn to avoid aposematic colours, not in isolation, but as part of specific patterns.

Behavioral threat and appeasement signals take precedence over static colors in lizard contests

Abstract The interplay between morphological (structures) and behavioral (acts) signals in contest assessment is still poorly understood. During contests, males of the common wall lizard (Podarcis muralis) display both morphological (i.e. static color patches) and behavioral (i.e. raised-body display, foot shakes) traits. We set out to evaluate the role of these putative signals in determining the outcome and intensity of contests by recording agonistic behavior in ten mesocosm enclosures. We find that contests are typically won by males with relatively more black coloration, which are also more aggressive. However, black coloration does not seem to play a role in rival assessment, and behavioral traits are stronger predictors of contest outcome and winner aggression than prior experience, morphology, and coloration. Contest intensity is mainly driven by resource- and self-assessment, with males probably using behavioral threat (raised-body displays) and de-escalation signals (foot shakes) to communicate their willingness to engage/persist in a fight. Our results agree with the view that agonistic signals used during contests are not associated with mutual evaluation of developmentally-fixed attributes, and instead animals monitor each other to ensure that their motivation is matched by their rival. We emphasize the importance of testing the effect of signals on receiver behavior and discuss that social recognition in territorial species may select receivers to neglect potential morphological signals conveying static information on sex, age, or intrinsic quality.

A 3D Reconstruction Method Based on Homogeneous De Bruijn-Encoded Structured Light

Structured light three-dimensional reconstruction is one of the important methods for non-contact acquisition of sparse texture object surfaces. Variations in ambient illumination and disparities in object surface reflectance can significantly impact the fidelity of three-dimensional reconstruction, introducing considerable inaccuracies. We introduce a robust method for color speckle structured light encoding, which is based on a variant of the De Bruijn sequence, termed the Homogeneous De Bruijn Sequence. This innovative approach enhances the reliability and accuracy of structured light techniques for three-dimensional reconstruction by utilizing the distinctive characteristics of Homogeneous De Bruijn Sequences. Through a pruning process applied to the De Bruijn sequence, a structured light pattern with seven distinct color patches is generated. This approach ensures a more equitable distribution of speckle information.

A miniature world: Revealing warring states period shell paintings from zhongshan state by multiple-methods

The use of shells as a medium for painting is an exceptionally rare discovery in archaeology, representing a art form that has been largely overlooked. In this study, we present two shell paintings of the Warring States period (476–221 BCE) discovered in Zhongshan State, Hebei, China. Employing various techniques, including microscopic observation, computed tomography (CT), X-ray fluorescence (XRF), multispectral imaging, and Raman spectroscopy, we non-destructively unveil the exquisite images obscured by soil and reveal the unparalleled shallow relief technique employed in their creation. The identified pigments for the different paintings include cinnabar, charcoal black, and malachite. These elaborate depictions offer insights into the costume, rituals, life, hierarchy, and art of the Warring States period. The meticulous use of prominent lines emphasizes color patches rather than the brushstrokes relied upon in later stereotypical Chinese painting, significantly reshaping previous notions about the early development of Chinese painting. This unique expression undoubtedly refreshes our understanding of early ancient art.

Optimizing Vision Transformers for Histopathology: Pretraining and Normalization in Breast Cancer Classification.

This paper introduces a self-attention Vision Transformer model specifically developed for classifying breast cancer in histology images. We examine various training strategies and configurations, including pretraining, dimension resizing, data augmentation and color normalization strategies, patch overlap, and patch size configurations, in order to evaluate their impact on the effectiveness of the histology image classification. Additionally, we provide evidence for the increase in effectiveness gathered through geometric and color data augmentation techniques. We primarily utilize the BACH dataset to train and validate our methods and models, but we also test them on two additional datasets, BRACS and AIDPATH, to verify their generalization capabilities. Our model, developed from a transformer pretrained on ImageNet, achieves an accuracy rate of 0.91 on the BACH dataset, 0.74 on the BRACS dataset, and 0.92 on the AIDPATH dataset. Using a model based on the prostate small and prostate medium HistoEncoder models, we achieve accuracy rates of 0.89 and 0.86, respectively. Our results suggest that pretraining on large-scale general datasets like ImageNet is advantageous. We also show the potential benefits of using domain-specific pretraining datasets, such as extensive histopathological image collections as in HistoEncoder, though not yet with clear advantages.

Exploring the key deteriorative microorganisms on ancient ivories unearthed from the Sanxingdui Ruins site during temporary cold storage.

The ancient ivories unearthed from the Sanxingdui Ruins site are valuable cultural relics, however, the microbial biodeterioration on ivories during temporary cold storage poses a great threat to their later long-term preservation. Here, the combination of high-throughput sequencing and biochemical assays was applied for the in-depth investigation of the key deteriorative microorganisms colonizing on the ivories and the tracing of their origin, as well as the assessment of the ethanol disinfection impact on the microbial communities on ivories. It was observed that the surfaces of ivories were scattered by the fungal patches of white, dark grey, and hedge green colors during cold storage. The high-throughput sequencing results showed that the genera Mortierella (38.51%), Ilyonectria (14.43%), Penicillium (1.15%), and Aspergillus (1.09%) were the dominant fungi, while Pseudomonas (22.63%), Sphingopyxis (3.06%), and Perlucidibaca (2.92%) were the dominant bacteria on ivories. The isolated Aspergillus A-2 resulted in the highest amount of calcium releasing from the degradation of hydroxyapatite (HAP), the main component of ivory, by the organic acids produced, including oxalic acid and citric acid. The fast expectation-maximization for microbial source tracking (FEAST) analysis revealed that the majority of the fungi (57.45%) and bacteria (71.84%) colonizing on the ivories were derived from the soils surrounding ivories in the sacrifice pits, indicating soils as the primary source for the spoilage microbes growing on ivories. The dominant strains could degrade cellulose, the key components of wet cotton towels commonly applied on ivories for moisture maintenance, aiding the spoilage microbes colonizing on ivories. Notably, the ivory disinfection with 75% ethanol during the cleansing significantly decreased the relative abundance of the dominant genera of Ilyonectria, Aspergillus, and Pseudomonas, with Mortierella becoming the dominant one on ivories. Together, the fungi, particularly Aspergillus and Penicillium, played a significant role in the microbial biodeterioration of unearthed ancient ivories by producing the organic acids. These results may improve the control of the microbial biodeterioration and develop more efficient strategies for the long-time conservation of unearthed ancient ivories and other cultural relics.

Efficacy Of Triamcinolone Injection In Management Of Oral Lichen Planus

Objective: To study the efficacy of triamcinolone injection in the treatment of oral lichen planus patients presented to the department of oral and maxillofacial surgery at KRL General Hospital Islamabad. Method: This study was conducted in the Department of Oral & Maxillofacial Surgery, Kahuta Research Laboratories Islamabad. 100 patients who fulfilled the inclusion-exclusion criteria were selected. All the enrolled patients were treated with intralesional TA injection once a week for 4 weeks. A 0.5ml TA (40mg/ml) dose was used. The subepithelial tissue just beneath the lesion and next to the normal mucosa was the exact location of the injection. The treatment was stopped earlier when all three of the symptoms of burning, pain and patch colour were removed. The patients were examined clinically on the 7th, 14th, and 21st day of treatment and based on the examination, the decision of the next dose was decided. The final examination of the patient was on the 28th day of treatment. To assess the oral pain and burning, we used the Visual Analogue Scale (VAS) having 10 grades (0-10). Results: The mean age of the patients in the study was 35.47±13.459 ranging from 18 to 65 years. In frequency of gender of the patients, there were 57(57%) male and 43(43.0%) female patients. In frequency of distribution of patients, 38(38.0%) patients had unilateral while the remaining 62(62.0%) had bilateral disorders. In frequency of efficacy, 87(87.0%) patients found with improved symptoms and 13(13.0%) were not improved/inefficient. Conclusion: This study concluded as much of previous literature concluded that the efficacy and safety of intralesional TA injection were found efficient after observation at 28th weeks of treatment. Keywords: Triamcinolone injection, Oral lichen planus, Efficacy, Reticular, Plaque.