Statement of problemThe optical properties of esthetic computer-aided design and computer-aided manufacturing (CAD-CAM) materials can change depending on the clinical situation. Studies that compare esthetic CAD-CAM materials based on their optical properties are lacking. PurposeThe purpose of this in vitro study was to evaluate the optical properties of esthetic CAD-CAM specimens after ultraviolet (UV) aging based on the type and thickness of the material. Material and methodsIn total, 240 plate-shaped specimens (14×12×1 mm and 14×12×2 mm) of a nanohybrid composite resin (Tetric CAD), a fine-structure feldspathic ceramic (Vitablocs Mark II), 2 different glass-ceramics (IPS Empress CAD and IPS e.max CAD), a zirconia-reinforced lithium silicate glass-ceramic (Celtra Duo), a polymer-infiltrated ceramic network (Vita Enamic), and 2 different resin nanoceramics (Cerasmart and Lava Ultimate) were fabricated (n=15). The optical parameters were analyzed by spectrophotometry before and after UV aging. The brightness (L∗), red green (a∗), yellow-blue (b∗), chroma (Ch), and hue (h) were measured, and the color difference (ΔE00) values were calculated. The translucency parameter (TP), total transmittance (Tt), and contrast ratio (CR) were also determined. Statistical analyses were performed with 1-way ANOVA, the Tukey honestly significant difference post hoc test, independent- and paired-samples t tests, and 2-way ANOVA (α=.05). ResultsSignificant interactions were observed for the aging process, material type, and thickness for all optical parameters (P<.05). L∗, TP, and Tt had lower values, while CR had higher values for the aging group than that of the control group (P<.05). The h, TP, and Tt values were higher, whereas the b∗ and CR values were lower for the 1-mm group than those of the 2-mm group (P<.05). The highest ΔE00 value was found in the Lava Ultimate 1-mm group (ΔE00=3.21) and 2-mm group (ΔE00=2.42). The lowest ΔE00 value was found in the Vitablocs Mark II 1-mm group (ΔE00=0.31). The highest TP and Tt and the lowest CR values were observed for Tetric CAD; the lowest TP and Tt, and the highest CR values were noted in Celtra Duo (P<.05). ConclusionsThe optical properties of the CAD-CAM specimens were affected by the aging process, material type, and thickness, and the color stability was clinically applicable in all CAD-CAM materials except groups Lava Ultimate and Cerasmart(ΔE00<2.25). Resin nanoceramics exhibited the greatest color changes after UV aging, and a 2-mm thickness is recommended to ensure acceptable color stability. The zirconia-reinforced lithium silicate glass-ceramic was the most opaque, with a 1-mm thickness providing increased translucency.