Introduction: Colorectal cancer (CRC) incidence in the US is declining overall but growing among young adults. Recently, The American Cancer Society (ACS) recently released the updated guidelines for CRC screening with a new recommendation for screening starting age 45 years in the general US population. However, there is a significant scarcity of data on the gender disparities for CRC in the young population. Methods: We analyzed the National Inpatient Sample (NIS) database for young onset (<50 yrs) CRC (yoCRC) hospitalizations from Jan. 2010 to Dec. 2014. Patients were analyzed in four different age groups (11-20, 21-30, 31-40 & 41-50 years) by using appropriate ICD-9 CM codes to compare the yoCRC related hospitalization trends in both genders. The trends were reflected using the weighted number of discharges for a particular gender group as the numerator and the US population at risk for a group of interest as the denominator. Trends in yoCRC-related hospitalizations were assessed by the linear by linear association using IBM SPSS 24.0 with a statistical significance of p<0.05. Results: The most significant finding of the study was that the CRC-related hospitalization trends in 41-50 yrs age females (20.1% relative increase) surpassed that of males (7.5% relative increase) from 2010-2014 (Figure 1). Similarly, age-adjusted yoCRC-related hospitalizations rates in the males relatively increased by 10.5% (from 171 to 189 per 100,000), 9.8% (from 590 to 648 per 100,000), and 7.5% (from 1284 to 1380 per 100,000) for age groups 21-30 yrs, 31-40 yrs and 41-50 yrs respectively (ptrend(Figure 2). Looking into the females’ CRC trends, age groups 21-30 yrs, 31-40 yrs and 41-50 yrs showed correspondingly increasing trends from 2010-2014 with relative increase by 13.6% (from 44 to 50 per 100,000), 5.4% (from 221 to 233 per 100,000), and 20.1% (from 985 to 1183 per 100,000) respectively (ptrend(Figure 3).150_A Figure 1 No Caption available.150_B Figure 2 No Caption available.150_C Figure 3 No Caption available.Conclusion: Our results show that the yoCRC-related hospitalizations are increasing in both genders, but this rate is particularly high in females. This alarming gender disparity in hospitalizations trends warrants further strides to address the CRC screening recommendations distinctions as per genders. Our study results endorse the opinion of ACS and CRC alliance about increasing incidence of yoCRC.