Aim: Evaluate the effect of denture cleansers and accelerated aging on the color stability of a commercially available maxillofacial silicone. Materials and Methods: A commercially available maxillofacial silicone cosmesil M511 was mixed according to manufacturer's instruction with the incorporation of three pigments, namely, Burnt sienna, Hansa Yellow, and Alizarin red and packed into the stone molds prepared using metal dies according to ASTM standards. After processing, initial color measurement was carried out 72 h following processing using a spectrophotometer. The samples were later subjected to disinfection and accelerated aging for 504 h and 1008 h following which color measurement was carried out. The results were analyzed using one-way ANOVA and Tukey's multiple comparison test (P Results: There was a statistically significant difference in the color stability of the silicone samples pigmented with Hansa Yellow than with Burnt Sienna and Alizarin Red after disinfection and 504 h of accelerated aging. Silicone samples disinfected with Fittydent denture cleanser showed better color stability than samples disinfected with neutral soap. There was a statistically significant difference in the color stability of the samples after 1008 h of accelerated aging irrespective of pigmentation and disinfection method. Conclusions: Silicone samples pigmented with Hansa Yellow had greater color stability than the samples pigmented with other two pigments after disinfection and 504 h of accelerated aging. After 1008 h of aging, all samples showed poor color stability irrespective of pigmentation and disinfection method.