The article explores the intricate interplay between mental health and socio-cultural factors across historical epochs and contemporary society. Beginning with primitive beliefs attributing health abnormalities to supernatural forces, the narrative traces the evolution of perspectives, from Hippocrates’ psychological approach to the medieval era’s religious-centric views. The colonial period witnessed mental health framed as abnormal behavior, emphasising somatogenic factors, leading to social isolation. As the twentieth century unfolded, a psychological lens gained prominence, acknowledging genetic predispositions. Examining a case study of a tribal man labelled “mentally ill” and lynched, the article questions the complex socio-economic issues obscured by the “mental illness” label. It argues for a holistic approach to mental health interventions, emphasizing community-centric strategies. The importance of understanding lay perspectives, addressing negative stereotypes, and recognizing vulnerable sections of society is highlighted. The article contends that mental health organizations must blend cultural values and scientific approaches. It proposes support groups, counselling, and awareness initiatives rooted in shared socio-cultural values. Community-based interventions, aligned with local characteristics, are seen as crucial for resilience in the face of disasters. The need for organizations to recruit locally to enhance cultural understanding and avoid disharmony is emphasized. The conclusion warns against underestimating socio-cultural values in interventions, as this may perpetuate negative perspectives. Structural constraints, both social and economic, are identified as key determinants of mental health.