Introduction: Colonic diverticular hemorrhage is a common cause of lower gastrointestinal bleedings. However, low detection rate of a responsible diverticulum for bleeding and high early rebleeding rate after endoscopic hemostasis, are clinical problems. Recently, several papers reported the usefulness endoscopic band ligation (EBL) for colonic diverticular hemorrhage. However, the efficacy and safety of EBL were unclear. Therefore, the aim of this study was to evaluate the efficacy and safety of EBL for colonic diverticular hemorrhage compared with endoscopic clipping. Methods: From April 2012 to March 2016, total 260 cases of 129 patients who were suspected diverticular hemorrhage in our hospital were enrolled. Urgent colonoscopy was performed within 24 hours from arrival to our hospital. Diverticular hemorrhage was diagnosed as active bleeding from a diverticulum, a visible non-bleeding vessel within a diverticulum, or a densely adherent clot despite vigorous irrigation based on the physician's decision. Hemostasis was performed with clipping or EBL. We evaluate the successful rate of the endoscopic procedure, early rebleeding rate within thirty days and adverse event between clipping and EBL groups. Results: Colonic diverticular hemorrhage was diagnosed in 85 of 260 cases (32.7%). EBL was firstly attempted in 35 cases. However EBL was failure in three cases despite sufficient suction, and was converted to clipping. Therefore, these three cases were subsumed in the clipping group. Successful rate of clipping and EBL were 100% (53/53) and 91.4% (32/35), respectively (p-value=0.066). Early rebleeding rate of clipping and EBL was 43.4% (23/53) and 6.3% (2/32) respectively (p-value < 0.05). Two patients in the clipping group were required for interventional radiology and surgery because of endoscopic treatment was failure. No adverse event was found in both groups. Conclusion: EBL is reasonable for hemostasis of colonic diverticular hemorrhage because of ligating the inverted diverticular with a bleeding vessel. Our data demonstrated that the rebleeding rate of the EBL group was significantly lower than that of the clipping group. Therefore, EBL would be the alternative endoscopic hemostasis for colonic diverticular hemorrhage. In conclusion, EBL would be safe, effective, and superior to clipping for the hemostasis of colonic diverticular hemorrhage.