Experience guides the development of business practices, and these practices in turn challenge economic analysis. In some cases the analytical challenge has been successfully met and economic science enriched. But economics has not yet attained perfection. Nevertheless, antitrust policy should depend on economic analysis if its purpose is to serve the ends of individual liberty and economic efficiency. To ignore economics leads to restrictions on commerce which can defeat the ultimate purposes of trade regulation despite good intentions. Even in furthering the political purposes of antitrust policy, such as the preservation of small firms, economic science is a helpful guide. Few trade practices are abusive under all circumstances. Sometimes a given practice is not only compatible with competition but may actually enhance it. Under different circumstances, the same practice may be a symptom of monopoly power without being a source of that power. For example, a particular device may be a vehicle of price discrimination that more fully exploits an already existing monopoly. These are the problems that form the subject of the first part of this paper. The second part of the paper deals with predatory tactics. Pushed to their extreme, these are tactics designed to destroy competitors; selling below cost is the leading instance of such predatory conduct. To study such economic warfare, it is necessary to consider the relative profitability of tacit collusion, cartel, and monopoly achieved by merger. Absent legal constraints, merger is generally the most efficient route to monopoly profit. These problems lead to the analysis of the forces underlying competition and of the role of antitrust policy in the third section of the paper. Since barriers to merger play a particularly important role in preserving competition, the fourth part of the article considers the effects on competition of those conglomerate firms that may owe their existence in large part to merger. In general, this discussion poses the questions of why certain firms engage in diverse activities and whether, if large size results, monopoly power becomes a possible consequence.