Colloidal Solution Research Articles

Infusion therapy during knee and hip arthroplasty operations in patients with diabetes

BACKGROUND. Hip and knee arthroplasty (HKA) are common surgical interventions that require balanced infusion therapy (IT), especially in patients with concomitant diabetes mellitus (DM).
 OBJECTIVE. To determine the effectiveness of balanced IT in the perioperative period for HKA in patients with diabetes.
 MATERIALS AND METHODS. A retrospective analysis of the inpatient charts of 50 patients who underwent HKA operations against the background of concomitant DM was performed. All patients were divided into two groups: 1) patients with hip arthroplasty; 2) patients with knee arthroplasty. The course of the perioperative period, the need for infusion support, and the development of complications were analyzed.
 RESULTS. All patients were aged from 38 to 86 years, had increased weight (body mass index – 26.0-29.4 kg/m2). There were no differences in general and anthropometric indicators between patients of the groups (p>0.05). IT was performed in all 50 patients (100.0 %) and consisted of crystalloids and polyionic drugs based on polyatomic alcohols and organic anions. Clinical and anamnestic data, the course of the perioperative period and the development of complications were of the same type in patients regardless of the location of the intervention (p>0.05).
 CONCLUSIONS. The IT program during HKA operations should include simple and balanced solutions of crystalloids and polyionic preparations based on polyatomic alcohols and organic anions. Colloidal solutions and blood preparations should not be included in the infusion program, except in cases of special indications. The use of such a program helps to reduce the number of perioperative complications and carbohydrate metabolism disorders.

Consensus of the Brazilian association of hematology, hemotherapy and cellular therapy on patient blood management: Acute normovolemic hemodilution and intraoperative autotransfusion

Autologous blood transfusion can be achieved through different techniques, including by the patient donating blood before surgery (pre-deposit), collecting blood from the patient immediately before the operation and replacing the volume with colloids or plasma expanders (acute normovolemic hemodilution) or through the salvage of lost blood, during or immediately after surgery, and its retransfusion after washing (intraoperative or postoperative recovery).We will focus on the two methods used intraoperatively that are of fundamental importance in the management and conservation of the patient's own blood.

ДИСПЕРСТІ ОРТАЛАРДЫҢ ОПТИКАЛЫҚ ҚАСИЕТТЕРІ

The aim of the study is to study light scattering, one of the optical properties of dispersed media. A number of optical methods for determining the size, shape and concentration of colloidal particles and macromolecules are based on the Tyndall effect. A ray of light passing through a colloidal solution is visible as a result of scattering, this type of scattering is called opalescence. Scientific discovery new data on optical effects occurring on magnetic colloids under the influence of magnetic and hydrodynamic fields have been obtained. To create neutral light filters controlled by a magnetic field, it is possible to use established diffraction scattering models with a small angle. The article defines the correspondence and errors of the J.W. Rayleigh or Clausius equations of light scattering intensity for a collide sulfur solution obtained experimentally to solve the problem.

The effects of an IV fluid bolus on mitral annular velocity and the assessment of diastolic function: a prospective non-randomized study

BackgroundAbnormal diastolic function is an independent predictor of adverse postoperative outcomes. Mitral annular tissue Doppler velocity (e’) is a key parameter for assessing diastolic function. The purpose of this study was to confirm that an acute increase in preload did not significantly impact the intraoperative measurement of e’ and secondarily evaluate the impact of this acute intravascular volume increase on the clinical assessment of diastolic function using a previously described simplified algorithm.MethodsThis was a prospective, non-randomized study in adult patients undergoing elective cardiac surgeries requiring transesophageal echocardiographic monitoring, arterial pressure and Swan-Ganz catheter placements as part of the surgical procedure. Following baseline echocardiographic and hemodynamic measurements, 500 ml of crystalloid solution was infused over 10 min. Hemodynamic and echocardiographic measurements were repeated 5 min after fluid administration.ResultsComplete data sets were available from 84 of the 100 patients who were enrolled in this study. There was no significant change in the values of e’. The average baseline was 7.8 ± 2.0 cm/s (95%CI: 7.4, 8.2) and 8.1 ± 2.4 (95%CI: 7.6, 8.6) following the fluid bolus (p = 0.10). All hemodynamic variables associated with increased intravascular volume (central venous pressure, pulmonary arterial pressures and stroke volume variation) changed significantly. The overall distribution of diastolic function grades did not change following fluid administration (p = 0.69). However, there were many individual patient differences. When using this simplified algorithm, functional grading changed in 35 patients. Thirty of these 35 changes were only a single grade shift. 22 patients had worse functional grading after fluid administration while 13 had improved grading. Nine patients with normal diastolic function at baseline demonstrated diastolic dysfunction after fluid administration while 6 patients with baseline dysfunction normalized following the fluid bolus.ConclusionWe confirmed that e’ is a robust measurement that is reproducible in the intraoperative setting despite variable vascular volume loading conditions, however, the clinical assessment of diastolic function was still altered in 42% of the patients following an intravenous fluid bolus.

Применение комплекса биологически активных веществ из Аronia melanocarpa в парафармацевтических фитоплёнках

The article presents the results of using non-pharmacopoeial plant raw material – dried leaves of the perennial cultivated chokeberry shrub Aronia melanocarpa (Michx.) Elliott. as a source of substances with anti-inflammatory and wound-healing effect. The development of a parapharmaceutical phytofilm based on a complex of biologically active substances from A. melanocarpa is described. The results of preclinical evaluation of the developed phytofilm in an experimental model of skin wound on outbred white rats are presented. The developed phytofilm is environmentally safe compared to synthetic analogues which production is accompanied by a negative environmental impact. Substances with antioxidant properties which can play the role of a medicinal base were found in the composition of aqueous extracts from chokeberry leaves: polyphenols – 7.4±0.7, tannins – 4.6±0.5 mg/cm3. The safety of using A. melanocarpa leaves as raw material for phytofilm has been confirmed in heavy metal tests. The composition and film-forming ability of chokeberry leaves aqueous extract, including polyvinyl alcohol (098-15(G)) (6%), food grade gelatin P-11 (0.5%), glycerin (GOST 6259-75) (0.4%), colloidal silver solution 200 mg/dm3 (1%) has been established. A. melanocarpa leaves extract application to the film-forming solution increases the final vapor permeability by 48% and solubility by 14%. The model experiment shows the effect of using the created phytofilm in the reparation of linear wounds, manifested as significant decrease in their length by 30% by the fifth day, by 25% by the seventh day compared with the control, as well as normalization of the skin histological structure by the tenth day.

A case of hemolytic-uremic syndrome that developed in a 5-year-old child due to acute intestinal infection with hemocolitis

Purpose: to demonstrate a case of hemolytic-uremic syndrome (HUS) in a 5-year-old child associated with an acute intestinal infection of unknown etiology, occurring with hemocolitis. Results. During clinical and laboratory observation, edematous syndrome, oligoanuria, severe microangiopathic hemolytic anemia (decrease in hemoglobin, haptoglobin, increase in Lactate dehydrogenase), thrombocytopenia, consumption coagulopathy, hyperazotemia, acute kidney injury (AKI) according to KDIGO grade 2 (increase in serum creatinine more than 2 times) developed. As part of complex therapy with balanced crystalloid solutions with stimulation of diuresis, it was possible to achieve rapid restoration of diuresis on the 2nd day of hospital stay without the use of renal replacement therapy; he also received antibiotics, anticoagulants, transfusion of fresh frozen plasma and red blood cell suspension. Hyperazotemia was relieved within 5 days, as was thrombocytopenia. The follow-up recovery of renal function showed.

Comparing silver and gold nanoislands’ surface plasmon resonance for bisacodyl and its metabolite quantification in human plasma

Gold and silver nanoparticles have witnessed increased scientific interest due to their colourful colloidal solutions and exceptional applications. Comparing the localized surface plasmon resonance (LSPR) of gold and silver nanoparticles is crucial for understanding and optimizing their optical properties. This comparison informs the design of highly sensitive plasmonic sensors, aids in selecting the most suitable nanoparticles for applications like surface-enhanced infrared spectroscopy (SEIRA) and biomedical imaging, and guides the choice between gold and silver nanoparticles based on their catalytic and photothermal properties. Ultimately, the study of LSPR facilitates the tailored use of these nanoparticles in diverse scientific and technological applications. Two SEIRA methods combined with partial least squares regression (PLSR) chemometric tools were developed. This development is based on the synthesis of homogeneous, high-dense deposited metal nanoparticle islands over the surface of glass substrates to be used as lab-on-chip SEIRA sensors for the determination of bisacodyl (BIS) and its active metabolite in plasma. SEM micrographs revealed the formation of metallic islands of colloidal citrate-capped gold and silver nanoparticles of average sizes of 29.7 and 15 nm, respectively. BIS and its active metabolite were placed on the nanoparticles’ coated substrates to be directly measured, then PLSR chemometric modelling was used for the quantitative determinations. Plasmonic citrate-capped gold nanoparticle substrates showed better performance than those prepared using citrate-capped silver nanoparticles in terms of preparation time, enhancement factor, PLSR model prediction, and quantitative results. This study offers a way to determine BIS and its active metabolite in the concentration range 15–240 ng/mL in human plasma using inexpensive disposable glass-coated substrates that can be prepared in 1 h to get results in seconds with good recovery between 98.77 and 100.64%. The sensors provided fast, simple, selective, molecular-specific and inexpensive procedures to determine molecules in their pure form and biological fluid.

Synthesis of Gold Clusters and Nanoparticles Using Cinnamon Extract-A Mechanism and Kinetics Study.

In this work, UV-Vis spectrophotometry, High Resolution Scanning Transmission Electron Microscopes and selected experimental conditions were used to screen the colloidal system. The obtained results complement the established knowledge regarding the mechanism of nanoparticle formation. The process of gold nanoparticles formation involves a two-step reduction of Au ions to Au(0); atom association and metastable cluster formation; autocatalytic cluster growth; ultra-small particle formation (1-2 nm, in diameter); particle growth and larger particles formation; and further autocatalytic crystal growth (D > 100 nm). As a reductant of Au(III) ions, a cinnamon extract was used. It was confirmed that eugenol as one of the cinnamon extract compounds is responsible for fast Au(III) ion reduction, whereas cinnamaldehyde acts as a gold-particle stabilizer. Spectrophotometry studies were carried out to track kinetic traces of gold nanoparticle (D > 2 nm) formation in the colloidal solution. Using the Watzky-Finke model, the rate constants of nucleation and autocatalytic growth were determined. Moreover, the values of energy, enthalpy and entropy of activation for stages related to the process of nanoparticle formation (Index 1 relates to nucleation, and Index 2 relates to the growth) were determined and found to be E1 = 70.6 kJ, E2 = 19.6 kJ, ΔH1 = 67.9 kJ/mol, ΔH2 = 17 kJ/mol, ΔS1 = -76.2 J/(K·mol), ΔS2 = -204.2 J/(K·mol), respectively. In this work the limitation of each technique (spectrophotometry vs. HRSTEM) as a complex tool to understand the dynamic of the colloidal system was discussed.

Abstract 7289: PancreaAlert: Intelligent nanoengineered biosensor for pancreatic cancer

Abstract Introduction: Pancreatic cancer accounts for 3% of cancer cases and 7% of cancer deaths in the United States. It is currently in the third position with respect to cancer-related deaths, and it is expected to move to second place as of 2040. This is mainly due to its diagnosis in the later stage. If detected in the first or second stage surgery can be performed thus increasing the patient’s survival rate. The current methods of diagnosis cannot do early stage or asymptomatic detection. So, detecting cancer-specific biomarkers can aid in the prognosis. Serum protein-based biomarkers carbohydrate antigen CA242, CA19-9, and carcinoembryonic antigen CEA are specific to pancreatic cancer. Thus, in this preliminary study, we aim to develop a nanoengineered electrochemical biosensor combined with machine learning to detect pancreatic cancer-specific biomarkers CA242, CA19-9, and CEA. Methodology: Nanoengineering the biosensor: The gold working electrode of the gold- biosensor (DRP-250AT) was coated with graphene oxide nano colloidal solution and kept in UV overnight for the graphene oxide nanosheet to crosslink with the working electrode. Detection of biomarkers using an electrochemical biosensor: First, a Crosslinker (DSP) was added to ethanol cleaned biosensor to bind the analytes. Following that antibody specific to each biomarker were added to the biosensors. The addition of TBS superblock prevented non-specific binding. Then different concentrations of biomarkers were added, and the corresponding sensor was subjected to various electrochemical analyses such as electrochemical impedance spectroscopy and voltammetry. SEM-EDAX analysis: The antigen-antibody binding on the biosensor's surface was confirmed. Automation and machine learning: Python code was developed to automate the analysis process and machine learning models (support vector machine and neural network) were used to classify the concentrations into various risk levels. The sensitivity of the developed tool was high when compared with conventional methods like ELISA and confocal microscopy. Results: From the electrochemical studies we found that with increasing concentration of biomarkers, there was a trend in output parameters: capacitance, resistance, impedance and area under the curve. By analyzing this trend, the concentrations of biomarkers can be detected. Using this data as input the machine learning model (accuracy greater than 80%) classified the concentrations into risk levels (normal, low risk, and high risk). Significance: Nanoengineering with graphene oxide nanosheets enhances the sensitivity of electrochemical biosensors. Automation and machine learning models help in the analysis of large datasets produced by this sensor. Overall, this device aids in the prognosis of pancreatic cancer. Our preliminary results are encouraging but more thorough research is required to make this diagnostic tool a working application. Citation Format: Meenal Karunanidhi, Hemalatha Kanniyappan, Edith Zhan, Ruth Mathew, Yani Sun, Junyi Wu, Yan Yan, Gnanasekar Munirathinum, Mathew T. Mathew. PancreaAlert: Intelligent nanoengineered biosensor for pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7289.

Simultaneous Formation of Polyhydroxyurethanes and Multicomponent Semi-IPN Hydrogels.

This study introduces an efficient strategy for synthesizing polyhydroxyurethane-based multicomponent hydrogels with enhanced rheological properties. In a single-step process, 3D materials composed of Polymer 1 (PHU) and Polymer 2 (PVA or gelatin) were produced. Polymer 1, a crosslinked polyhydroxyurethane (PHU), grew within a colloidal solution of Polymer 2, forming an interconnected network. The synthesis of Polymer 1 utilized a Non-Isocyanate Polyurethane (NIPU) methodology based on the aminolysis of bis(cyclic carbonate) (bisCC) monomers derived from 1-thioglycerol and 1,2-dithioglycerol (monomers A and E, respectively). This method, applied for the first time in Semi-Interpenetrating Network (SIPN) formation, demonstrated exceptional orthogonality since the functional groups in Polymer 2 do not interfere with Polymer 1 formation. Optimizing PHU formation involved a 20-trial methodology, identifying influential variables such as polymer concentration, temperature, solvent (an aprotic and a protic solvent), and the organo-catalyst used [a thiourea derivative (TU) and 1,8-diazabicyclo [5.4.0]undec-7-ene (DBU)]. The highest molecular weights were achieved under near-bulk polymerization conditions using TU-protic and DBU-aprotic as catalyst-solvent combinations. Monomer E-based PHU exhibited higher Mw¯ than monomer A-based PHU (34.1 kDa and 16.4 kDa, respectively). Applying the enhanced methodology to prepare 10 multicomponent hydrogels using PVA or gelatin as the polymer scaffold revealed superior rheological properties in PVA-based hydrogels, exhibiting solid-like gel behavior. Incorporating monomer E enhanced mechanical properties and elasticity (with loss tangent values of 0.09 and 0.14). SEM images unveiled distinct microstructures, including a sponge-like pattern in certain PVA-based hydrogels when monomer A was chosen, indicating the formation of highly superporous interpenetrated materials. In summary, this innovative approach presents a versatile methodology for obtaining advanced hydrogel-based systems with potential applications in various biomedical fields.

Advancements in Uncooled Bolometer Technology: Shortwave Infrared Detection via CuFeSe2 Nanocrystal Colloidal Thin Films

Microbolometers have emerged as a cost‐effective alternative to cooled infrared photon detectors, albeit with certain trade‐offs in terms of responsivity (), detectivity (), and response time (). The research in this field is driven by the potential applications in night vision devices, military surveillance, and autonomous vehicles, leading to a growing interest in exploring new materials to bridge the performance gap between cooled photon detectors and uncooled bolometers. This study focuses on the optoelectronic and bolometric characteristics of nanocrystals (NCs) in a colloidal solution. These NCs exhibit a significant change in resistivity (ρ) when subjected to temperature variations ranging from 170 to 400 K. Specifically, the temperature coefficient of resistance (TCR), α, is 1.9% per Kelvin for a room temperature resistivity of 505 Ω cm. Furthermore, the responsivity of NCs is reported to be 0.101 A W−1, and the Hall mobility of the colloidal solution is determined as . Finally, a comprehensive comparison is conducted between the performance metrics of established bolometer materials, such as VOx and a‐Si, and those of colloidal NCs. Based on the results, colloidal NCs are a promising option for future bolometer technology.

Balanced Crystalloid Solution or Normal Saline in Fluid Resuscitation in Critically Ill Patients: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

Background: Both balanced crystalloid solution and normal saline are commonly used for fluid therapy in critically ill patients. However, the association between the types of crystalloid solution and patient outcomes remains inconclusive. Materials and Methods: The authors performed a search using Pubmed, Embase, and Cochrane Central Register through January 2022. Randomized controlled trials (RCTs) comparing balanced crystalloids and normal saline in non-perioperative fluid resuscitation for critically ill adult patients were included. The primary outcome was 30-day mortality. A trial sequential analysis (TSA) was performed to assess the effect of each type of fluid on the outcomes. Secondary outcomes included the incidence of acute kidney injury (AKI), renal replacement therapy (RRT), and other pre-specified outcomes. Results: Ten RCTs were identified and included 36,233 participants. Between the balanced crystalloids and the normal saline group, there were no significant differences in mortality at 30 days (relative risk [RR] 0.95, 95% confidence interval [CI] 0.89 to 1.02, I²=0), the incidence of AKI (RR 0.95, 95% CI 0.90 to 1.01, I²=0), and RRT (RR 0.93, 95% CI 0.86 to 1.01, I²=13). However, patients receiving balanced crystalloids demonstrated a significantly lower serum chloride level than the patients receiving normal saline (MD –1.95, 95% CI –3.45 to –0.45, I²=99). There was also no mortality difference in the sepsis and traumatic brain injury subgroups. The TSA confirmed the absence of an effect on mortality at 30 days and the incidence of AKI. Conclusion: In critically ill patients, the use of balanced crystalloids does not decrease 30-day mortality or the incidence of AKI and RRT. However, data in specific subgroups of patients were underpowered and further studies are required. There were signals of benefit and risk of the balanced salt solution in the subgroups of sepsis and traumatic brain injury. Trial registration: The present study was registered in the PROSPERO database, CRD42021275796. Keywords: Balanced crystalloid; Normal saline; Critically ill patients; Mortality; Acute kidney injury

The Management of Spinal and Epidural Anesthesia-Related Hypotension in the United States During Cesarean Childbirth.

This study delves into the prevalence of spinal anesthesia-induced hypotension during cesarean (c-section) childbirth, focusing on existing treatments and their efficacy. Currently, neuraxial analgesia is the most efficient method for alleviating pain during c-sections, but its major side effect, hypotension, necessitates a thorough understanding of the available treatment options. A scoping review was conducted using PubMed and Rayyan, with inclusion criteria being English peer-reviewed articles from the last five years, involving nulligravida/primigravida women under 35 years old in the United States. The research reveals various treatments to mitigate spinal anesthesia-induced hypotension. Norepinephrine and epinephrine have demonstrated effectiveness in maintaining blood pressure while reducing adverse maternal outcomes following delivery. When comparing fixed-rate infusions of norepinephrine to phenylephrine, norepinephrine demonstrated lower rates of bradycardia (p=0.004), thereby reducing the necessity for bolus atropine rescue (p=0.01). Furthermore, the use of colloid solutions during c-sections significantly decreased the incidence of hypotension when compared to crystalloid solutions (p<0.00001). Non-pharmacological methods, such as lower extremity wrapping and elevation, exhibited higher systolic and diastolic blood pressures, along with higher usage of ephedrine when compared to control groups. Pharmacological treatments proved more effective than non-pharmacological interventions in preventing maternal hypotension during c-sections. Notably, colloid preloading emerged as the most effective approach, helping to maintain maternal blood pressure, cardiac output, and heart rate while also minimizing the amount of ephedrine required and reducing anesthesia-related adverse effects. However, the study suggests the need for further investigations to determine the optimal dosage for colloid preloading. This research provides valuable insights into enhancing maternal well-being during c-sections by addressing the issue of neuraxial anesthesia-induced hypotension.

Insights into Co and Fe-doping effects of mesoporous CeO2 catalysts for dry reforming of glycerol to syngas production

The dry reforming of glycerol (GDR) is one of the alternatives for syngas production by utilizing biodiesel byproduct glycerol and CO2. The development of highly active and stable catalyst is significantly important to achieve GDR process, and the current work provides insights into Co and Fe-doping effects of mesoporous CeO2 (CoFeCe) catalysts synthesized by the colloidal solution combustion method. The prepared catalysts presented the uniform mesoporous structure, the doping of Co and Fe metals resulted in stronger metal-support interaction. The GDR experimental data were compared with the non-stoichiometric thermodynamic equilibrium values. The conversions of glycerol and CO2 were increased with increasing the reaction temperatures due to the endothermic GDR reaction, and the H2/CO produced in syngas was in the range of 0.7–1.4. Due to the improvement of Co and Fe metals in the mesoporous structure of CeO2 catalyst, the 7CoFeCe catalyst exhibited excellent and stable GDR performance and no significant signs of deactivation were observed during 76 h test, and the results indicated that the enhanced interaction and high dispersion of Co and Fe in mesoporous CeO2 catalyst could inhibit carbon formation and promote GDR reaction.

The Effect of Albumin Replacement on Vasopressor Duration in Septic Shock in Patients With Hypoalbuminemia.

The use of albumin resuscitation in septic shock is only recommended in patients who have received large volumes of crystalloid resuscitation regardless of serum albumin concentration. The role of albumin is still largely debated and evidence to support its use still lacking. The objective of this study was to evaluate whether albumin replacement increases the number of vasopressor-free days in patients with septic shock and hypoalbuminemia. A retrospective analysis was conducted to assess the effect of albumin replacement in septic shock. Hypoalbuminemic patients with septic shock who received albumin were retrospectively compared with a cohort who did not. The primary outcome was number of vasopressor-free days at day 14 from shock presentation, which was analyzed using an adjusted linear regression model to adjust for confounders. There was no difference in vasopressor-free days at day 14 in patients who received albumin versus those who did not, after adjusting for confounders of exposure (0.50, 95% CI = -0.97 to 1.97; P = 0.502). There also was no difference in secondary outcomes except for need for invasive mechanical ventilation (MV), which was significantly lower in patients who received albumin (61 [54.4%] vs 88 [67.7%]; P = 0.035). We observed no difference in vasopressor-free days at day 14 in patients with hypoalbuminemia who received albumin compared with those who did not. However, patients who received albumin required significantly less MV although further studies are warranted to assess this effect.

Designing sensing material with fractal geometry: A gateway for enhanced ethanol sensing under ambient conditions

In this work, a comparative study of ethanol vapor sensing is reported for tin oxide based vertical fractal structures (VFSs) against non-fractal structures (NFSs). The materials were synthesized by cost-effective microwave synthesis route followed by controlled drying of tin oxide colloidal solution. A thin layer of fractal material was coated on an ordinary glass capillary that served as the tubular sensor. While the VFS sensor responded well to ethanol vapors under ambient conditions with faster response (τres) of ∼ 8.2 ±0.5 s and recovery time (τrec) of ∼ 10.3 ± 0.5 s, respectively, the NFS sensor exhibited τres ∼15.2±1.0 s and τrec∼ 38.4±1.8 s. The performance of the VFSs was found to be satisfactory when tested under varying humid conditions (∼ 45 RH% to 90 RH%). The sensor exhibited a low detection limit of 1 ppm ethanol vapor. The better sensing properties are attributed to the characteristic patterned growth of fractals with interconnections ranging from nano to macro-scale, inter-crossing of fractal branches, surface as well as 3D roughness which are hallmarks of fractal geometry. In addition to this remarkable ethanol vapor sensing characteristics, easy and cost-effective fabrication process encourages to develop "single use" sensors as breath analyzer devices that can curb the risk of infection from person to person. This study projects the use of VFS samples and sensors fabricated thereof as reliable and economical disposable sensors.

A Review of Artificial Intelligence Methods in Predicting Thermophysical Properties of Nanofluids for Heat Transfer Applications

This present review explores the application of artificial intelligence (AI) methods in analysing the prediction of thermophysical properties of nanofluids. Nanofluids, colloidal solutions comprising nanoparticles dispersed in various base fluids, have received significant attention for their enhanced thermal properties and broad application in industries ranging from electronics cooling to renewable energy systems. In particular, nanofluids’ complexity and non-linear behaviour necessitate advanced predictive models in heat transfer applications. The AI techniques, which include genetic algorithms (GAs) and machine learning (ML) methods, have emerged as powerful tools to address these challenges and offer novel alternatives to traditional mathematical and physical models. Artificial Neural Networks (ANNs) and other AI algorithms are highlighted for their capacity to process large datasets and identify intricate patterns, thereby proving effective in predicting nanofluid thermophysical properties (e.g., thermal conductivity and specific heat capacity). This review paper presents a comprehensive overview of various published studies devoted to the thermal behaviour of nanofluids, where AI methods (like ANNs, support vector regression (SVR), and genetic algorithms) are employed to enhance the accuracy of predictions of their thermophysical properties. The reviewed works conclusively demonstrate the superiority of AI models over the classical approaches, emphasizing the role of AI in advancing research for nanofluids used in heat transfer applications.

Tailoring plasmonic sensing strategies for the rapid and sensitive detection of hypochlorite in swimming water samples.

Atunable plasmonic sensor has been developedby varying the dextran content in the initially synthesized dextran-gold nanoparticle (dAuNPs) solution. A colloidal nanogold solution (dAuNPs-Sol) was initially prepared using dextran and gold salt in alkaline media by a one-pot green synthetic route. The dAuNPs-Sol was combined with varying amounts of dextran (ranging from 0.01 to 30.01%) to create a tunable probe, along with different solid formats, including tablet (dAuNPs-Tab), powder (dAuNPs-Powder), and composite (dAuNPs-Comp). Both the liquid and solid phase plasmonic probes were characterized using UV-vis spectroscopy, transmission electron microscopy (TEM) dynamic light scattering (DLS), and zeta potential analysis. The impact of dextran content in the dAuNP solution is studied in terms of surface charge and hydrodynamic size. The influence of operational treatments used to achieve solid dAuNPs probes is also explored. All plasmonic probes were employed to detect a broad range of OCl¯ concentrations (ranging from µM to mM) in water through aggregation followed by calculating a lower and upper limit of detection (LLoD, ULoD) of the proposed colorimetric sensors. Results indicate that the most sensitive detection is achieved with a lower dextran content (0.01%), which exhibits an LLoD of 50µM. The dAuNPs-Sol sensor is selective and demonstrates real-world applicability, as confirmed by interference analysis and successful testing with various water samples. Additionally, it is found that a 20 × concentration of dextran-coated gold nanoparticles could be attained without any changes in the particle morphology. This concentration is achieved through a straightforward process that does not require the use of a centrifuge machine. This finding highlights the practicality and simplicity of the method, indicating its potential for scalable and cost-effective production of concentrated dAuNPs without compromising their structural integrity.

Isotonic hydroxyethyl starch is ineffective in restoring blood pressure during experimental septic shock: Implications for fluid resuscitation strategies

Objectives: The objectives of the study were to evaluate the effect of isotonic or hypertonic hydroxyethyl starch (HES) solutions on blood pressure and to assess the influence of the neurohypophyseal system on this response during experimental septic shock. Male Wistar rats were randomly allocated to undergo either cecal and ligation puncture (CLP) or a simulated surgical procedure (sham). Materials and Methods: Of 6 h post-surgery, either isotonic saline (0.9% sodium chloride, 4 mL/kg), isotonic (HES; at doses of 4, 8 or 16 mL/kg), or hypertonic saline-HES (HS-HES; 4 mL/kg) was administered through the endovenous route, followed by the recording of blood pressure and heart rate. In addition, the levels of sodium, vasopressin, and oxytocin were evaluated after the fluid infusion. Results: The administration of HES did not have a significant effect on blood pressure in our study. However, the HS-HES solution increased plasma osmolality, sodium, vasopressin, and oxytocin levels. Furthermore, the HS-HES induced a transient elevation in blood pressure immediately after infusion, which could be completely blunted by the pre-administration of a V1-vasopressin antagonist. Conclusion: Our results demonstrate that the infusion of an isotonic blood volume expander during experimental septic shock is ineffective in restoring blood pressure due to blood vessel compliance. In contrast, the infusion of a hypertonic solution stimulates vasopressin secretion and can transiently restore blood pressure.

A Review on Polymers for In situ Drug Delivery System

In situ gels have become one of the most popular and widely used techniques. These systems offer a number of benefits, including simple manufacturing, ease of use, improved adherence, and patient comfort by reducing drug administration frequency thanks to the unique characteristics of the sol to gel transition. The 'sol-gel' process involves hydrolysis, polymerization, or condensation of the precursor to form a colloidal suspension or solution. These in situ gelling methods gel at the accomplishment site since they can be administered in solution form. This review focused mostly on the introduction, advantages, disadvantages and types of polymers used to prepare in situ gels.