The current research work enlightens the novelistic approach for trans-cranial specificity of API which can be achieved by designing an effective nanosized aripiprazole loaded bio-nanoemulgel. In this research work an effort was made to isolate a novel biopolymer from Nelumbo nucifera and screened its biopolymeric potential & in-built retardability. The isolated biopolymer is used as bio-stabilizer and bio-retardant for designing the formulation.All the formulations were evaluated for its evaluation parameter including in-vitro release studies, pharmacokinetic and pharmacodynamics parameters. In this study insignificant amount of drug was noticed in the blood which indicates that majority of drug might has been reached to brain via neural pathway mechanism.Apart from this, the biopolymer can be used to deliver APIs for both systemic and local deliveryby suitably designing formulations like nanogels, hydrogels, bio-nanogels, in-situ nanogels, flexy films, bio-niosome, pro-niosome, transferosome, desmosomes, cubosomes, liposome, solid-lipid nanoparticle, colloidal gels. In this research work an innovative attempt has been made to isolate biopolymer fromNelumbo nucifera. The biopolymer possesses unique in-built property like stabilizer and retardant due to its proteinaceous and carbohydrate nature. The biopolymers are completely safe, nontoxic and Generally Regarded as Safe (GRAS) and gentle to cell line hence this biopolymer can be used as bio-carrier for various drug loaded novel drug delivery systems like nanosized transdermal patches, nanosuspensions, nanocrystals and nanocomposites.