We are reporting a clinical case of the complex histology of an oral sample from an 8-year-old girl. The histology analysis shares characteristics of a primordial odontogenic tumor (POT) and adenomatoid odontogenic hamartoma (AOH). The clinical evaluation reveals a left submandibular soreness and the presence of 1 cm in diameter radiolucent image in the region of the mandibular third molar with expanded and thin cortical bone. After enucleation, we obtained a white soft mass, showing on histology an ameloblastic epithelium and a stellate reticulum enveloping hypercellular myxoid connective tissue. On another field, the cells morphologically resembled odontoblasts; nevertheless the duct-like structures were absent. Some odontogenic tumors are lesions that are difficult to diagnose because of their histologic complexity and, in many of these cases, they are considered as unclassifiable hybrid or collision tumors. In summary, this rare and interesting case report should be characterized by a consensus of oral pathology experts. We are reporting a clinical case of the complex histology of an oral sample from an 8-year-old girl. The histology analysis shares characteristics of a primordial odontogenic tumor (POT) and adenomatoid odontogenic hamartoma (AOH). The clinical evaluation reveals a left submandibular soreness and the presence of 1 cm in diameter radiolucent image in the region of the mandibular third molar with expanded and thin cortical bone. After enucleation, we obtained a white soft mass, showing on histology an ameloblastic epithelium and a stellate reticulum enveloping hypercellular myxoid connective tissue. On another field, the cells morphologically resembled odontoblasts; nevertheless the duct-like structures were absent. Some odontogenic tumors are lesions that are difficult to diagnose because of their histologic complexity and, in many of these cases, they are considered as unclassifiable hybrid or collision tumors. In summary, this rare and interesting case report should be characterized by a consensus of oral pathology experts.