Background: Adolescence is a critical period for the development of health-related behaviors and the onset of psychological distress, including anxiety, depression, and stress. Physical activity has been associated with improved mental health, but its specific relationship with psychological distress in adolescents remains unclear.Objective: To evaluate the association between physical activity levels and psychological distress (stress, anxiety, and depression) in adolescents.Methods: A cross-sectional study was conducted on 109 adolescents aged 14-19 years from the University of Lahore and Beacon House School System, Valencia Campus, Lahore. Participants were recruited through non-probability convenience sampling. Psychological distress was assessed using the DASS-21, and physical activity levels were measured with the PAQ-A. Data were analyzed using Spearman’s rank correlation and Chi-square tests via SPSS version 23.Results: Significant but weak negative correlations were found between physical activity and stress (Spearman’s rho = -0.236, p = 0.013) and depression (Spearman’s rho = -0.219, p = 0.022). The association with anxiety was not significant (p = 0.075).Conclusion: Higher physical activity levels were associated with lower stress and depression among adolescents, suggesting potential mental health benefits of regular exercise.