Lack of sleep among college students is currently a massive epidemic affecting millions. Sleep duration and quality is an important determinant of overall health, and is related to health behaviors (physical activity (PA) & diet) and outcomes (mental health). But little is known about these relationships among college students. PURPOSE: Examine how PA, depression, body mass index (BMI), fruit and vegetable consumption (FVC), and academic performance differed based on sleep quality and duration. METHODS: Students completed an online survey, self-reporting their sex, height, weight, grade-point average (GPA), PA levels, FVC, and also responded to questions regarding mental health and sleep. Participants were grouped into those who reported less <4 or ≥4 nights of restful sleep/week. Paired samples t-tests examined differences in the aforementioned PA, FVC, BMI, and GPA between groups. Chi-square tests for independence examined differences in mental health (depression and stress) based between groups. RESULTS: 4380 participants responded to the sleep question, the majority of whom were women (59.2%) and non-Hispanic white (76.1%). For all participants, those who reported better sleep reported significantly higher moderate PA (p = .045), vigorous PA (p < .001), weekly MET-min (p < .001), and GPA (p < .001), whereas BMI (p = .627) and FVC (p = .107) did not differ between groups. When split by sex, the same results were revealed for women, but among men the only significant differences were in GPA (p = .042) and vigorous PA (p = .019). Those who reported better sleep also reported significantly less symptoms of depression regardless of sex (p < .001). CONCLUSION: A positive relationship between sleep and PA was found for women. In men, only vigorous PA was found to have a positive relationship with sleep. Though, a positive relationship between sleep and academic performance was evident for both sexes. In addition, better sleep was associated with better mental health regardless of sex. In summary, findings highlight the importance of more education on the importance in the relationship of sleep and better academic performance and mental health. Further research is required to examine the relationship, in particular directionality, between the amount PA and the duration of sleep in college students.