The zero waste approach introduces a novel perspective to waste management, allowing for the categorization of waste at its origin. This enables each identified waste group to be assessed and optimized individually. One of these optimization studies is the optimization of waste collection and transportation. Container numbers, placement and collection routes of vehicles are very important for optimizing collection and transportation. In this study, the number of containers placed in Karaman, their placement, the distance between the containers and the optimum distances that should be and the vehicle route optimization were made. The analysis of the number of containers and their placement in Karaman shows us that the number of containers is not used properly and the distance between the containers is very short (33 meters). Moreover, studies on optimizing routes in five pilot areas have led to an average efficiency gain of 32%, characterized by saving 17 kilometers, 50 minutes, and 8 liters of fuel per route. Based on these findings, a 32% improvement is anticipated not only in economic and time efficiency but also in reducing the carbon footprint during the collection and transportation stages.