Surabaya is a fast-growing city facing challenges in infrastructure development, posing a threat to cultural heritage and historic areas. The Kalimas area has been abandoned, negatively impacting the environment. Cultural heritage is valuable as it instills pride, holds significance in civilization, and can improve the quality of life (QOL). The World Health Organization (WHO) defines the quality of life as an individual's perception of differences in life based on culture and the surrounding environment. This study aims to determine the impact of physical conditions in slum settlements on the QOL of the community and identify the slum settlement variables that can improve residents' QOL. The study uses a quantitative approach with analytical techniques such as literature review and multiple linear regression to analyze land characteristics, socio-economic factors, and physical characteristics. QOL is measured using the WHOQOL questionnaire. The data collection methods include secondary data from the Department of Housing, Settlement Areas and Land, and Bappedalitbang of Surabaya City, as well as primary data from observations, questionnaires, and interviews with the research sample. The results indicate that slum settlement variables significantly affect four domains of QOL: physical health, psychology, environment, and social relationships. However, physical characteristics partially do not affect the psychological, environmental, and social relationship domains.