The purpose of this study is to investigate the effect of local wall thinning on the collapse of elbow subjected to internal pressure and bending moment. Thus, the nonlinear three-dimensional finite element analyses were performed to obtain the collapse moment of elbow containing various wall thinning defects located at intrados and extrados under two loading modes (closing and opening modes) with internal pressure. From the results of analysis, the effect of wall thinning defect on the global moment-rotation behavior of elbow was discussed, and the dependence of collapse moment of elbow on wall thinning depth, length, and circumferential angle was investigated under different loading mode and defect location.