Collagen Supplementation Research Articles

Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects.

Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects. Forty healthy adult non-pregnant/non-lactating women (aged 38-50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow's feet region; as well as hair strength and hair fall. It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value <0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value <0.01. SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow's feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.

Influence of available oral collagen supplementation on the function of joints and skin

Introduction and purpose: In our work, we focused on presenting the role of collagen supplementation and its impact on skin and joint health. We considered studies discussing the differences in the effects of collagen from various plant and animal sources. We also examined the influence of the degree of hydrolysis on the absorbability of the supplement. The aim of the paper is to comprehensively summarize knowledge on collagen supplementation, differentiating between its sources and forms. Material and methods: In our paper, we endeavored to address the subject of oral collagen supplementation comprehensively. We explored studies about various forms and sources of collagen. We also delved into the collagen supplementation impact on skin and joints health and impact of additives in enhancing the positive effect of collagen . State of knowledge: Oral collagen supplementation can be beneficial for skin and joints health. It promote collagen synthesis in human body increasing strength of skin and joints. The higher the degree of collagen hydrolysis, the more easily it is absorbed by the body. Additives in the form of vitamin C and A can enhance collagen synthesis. Results and conclusions: This review article indicates a growing interest in oral collagen supplementation and its impact on health. Although there are encouraging findings regarding positive effects, further research is necessary to better understand and determine the optimal conditions for achieving maximum supplementation benefits. This information may be crucial for clinical decisions made by physicians regarding joint reinforcement and anti-aging effects on the skin.

Supplementation of hydrolyzed collagen to the aging process of the skin: A review

Background: The aging of the skin has emerged as a significant concern, not only among older individuals but also among the younger population, given the increasing trend of longevity. Consequently, there has been a notable rise in the utilization of dietary supplements in recent years. Furthermore, a substantial body of scientific research suggests that the inclusion of hydrolyzed collagen in supplementation can play a significant role in mitigating the visible signs of skin aging. The primary aim of this study is to compile and present a comprehensive summary of the existing evidence pertaining to the effects of hydrolyzed collagen supplementation on human skin. Methods: This study conducted a narrative review to assess the efficacy of collagen administration in addressing skin aging. The literature search employed the keywords (collagen) AND (skin aging) to identify relevant articles, and the search was conducted on the PubMed database. The included articles' findings were systematically reviewed and presented in a narrative format to provide an overview of the current understanding of collagen supplementation in relation to its impact on skin aging. Results: We included fourteen articles in this review based on the eligibility criteria. Skin hydration was higher in most of the studies that favored collagen compared to placebo. Ten of 14 articles reported higher skin elasticity following collagen administration. There were six articles assessing skin roughness between both groups and all of them reported lesser skin roughness in the collagen group. Conclusion: Hydrolyzed collagen can delay and improve the signs of skin aging by improving skin hydration and elasticity, and reducing skin roughness.

Nutritional interventions for preventing and treating pressure ulcers.

Nutritional interventions for preventing and treating pressure ulcers.

Maxillary Sinus Augmentation with Xenogenic Collagen-Retained Heterologous Cortico-Cancellous Bone: A 3-Year Follow-Up Randomized Controlled Trial.

Sinus augmentation procedures have become a valuable solution for patients with posterior maxillary edentulism. The objective of this study was to explore the efficacy and safety of porcine xenograft with collagen supplementation as a potential alternative to autologous bone grafts in lateral sinus augmentation over a three-year follow-up period. Twelve patients, each with bilateral posterior maxillary edentulism, were enrolled and randomly allocated to receive either a porcine xenograft or an autologous graft. Comprehensive assessments, including clinical and radiographic evaluations, were conducted at specific intervals, including implant stability, marginal bone loss, prosthetic and biological complications, and patient preferences. The results demonstrated no significant differences between the two graft materials in terms of implant survival, marginal bone loss, and patient preferences after three years of follow-up. Only one implant was affected by peri-implantitis, and prosthesis-related complications were present in one patient possibly due to bruxism. In conclusion, these findings suggest that a porcine xenograft with collagen supplementation may be a viable alternative to an autograft in lateral sinus augmentation procedures. The high implant survival rate, minimal complications, and patient satisfaction indicate the potential clinical relevance of this graft material and should be further investigated to confirm these promising results.

Clinical studies and meta-analysis on the effects of collagen, vitamin, and nutrient supplementation for the rejuvenation of collagenic fibers: a systematic review

Introduction: Collagen prevails in connective tissues, constituting 80% of the dry weight of human skin. Aging induces a decline in enzymes involved in the post-translational processing of collagen, reducing the number of fibroblasts that synthesize collagen and the vessels that irrigate the skin. Oral ingestion of hydrolyzed collagen together with vitamins and nutrients (especially apple exosomes) increases the levels of collagenderived peptides in the bloodstream and improves skin properties. Objective: It was to carry out a systematic review to elucidate the main results of clinical studies and meta-analyses of clinical studies on the effects of supplementation of types of collagen, vitamins, and nutrients for the rejuvenation of collagen fibers. Methods: The search was carried out from October to December 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 122 articles were found, and 12 articles were evaluated in full, and 07 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 26 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=62.4%&gt;50%. Oral nutritional supplements containing collagen peptides can reduce skin vulnerability in the elderly and thus prevent conditions such as skin lesions. The direct effects of collagen peptides on fibroblasts, M2-like macrophages, and mechanisms related to oral tolerance are the possible mechanisms for the beneficial effects of collagen supplementation. Special collagen peptides together with acerola extract, vitamin C, vitamin E, biotin, and zinc showed a significant improvement in the skin's collagen structure. The proven positive nutritional effect on collagen structure was fully consistent with the quality of healthy skin. Finally, apple-derived nanovesicles (exosomes) also reduce the degradation of the extracellular matrix, increasing collagen synthesis (COL3A1, COL1A2, COL8A1, and COL6A1) and negatively regulating the production of metalloproteinases.

Oral collagen supplementation in 2nd degree burn and chronic pressure ulcers

Oral collagen supplementation in 2nd degree burn and chronic pressure ulcers

A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen.

Hydrolysed collagen supplements are reported to fight the signs of aging and improve skin appearance, but more authoritative clinical evidence is needed to support efficacy. This randomised, double-blind, placebo-controlled study evaluated the efficacy of a supplement containing hydrolysed collagen and vitamin C (Absolute Collagen, AC) on biophysical parameters and visible signs of aging for skin, scalp, and hair, when taken daily or every 48 hours. We measured dermal collagen using confocal microscopy and high-resolution ultrasound. Hydration, elasticity, wrinkles, and clinical trichoscopy were measured in parallel to expert visual grading. Efficacy measures were recorded at baseline, week 6, and week 12. Following 12 weeks daily use of the AC supplement, using confocal microscopy, we observed a significant 44.6% decrease in fragmentation vs. placebo (p < 0.01). We also measured a change in the ultrasound LEP (low echogenic pixel) ratio comparing upper and lower dermis (-9.24 vs. -7.83, respectively, p=0.05), suggesting collagen improvements occurred more in the upper dermal compartment. After 12 weeks vs. placebo, skin hydration was increased by 13.8% (p < 0.01), R2 elasticity index was increased by 22.7% (p<0.01), and Rz profilometry index was decreased by 19.6% (p < 0.01). Trichoscopy showed an average 11.0% improvement in scalp scaling and a 27.6% increase in the total number of hairs counted vs. placebo (p=n.s.). This was associated with a 31.9% increase in clinical grading score for hair healthy appearance (p < 0.01). The AC supplement has shown clinical benefits for skin, scalp, and hair, when used either daily or every 48 hours, over a 12-week period.

A study on the knowledge and attitudes of dietitians and their clients about collagen

This study aimed to assess the opinions of dietitians and their clients regarding their knowledge and use of collagen and to determine their level of knowledge regarding the use of collagen supplements. It was conducted on 30 dietitians and 125 clients in Istanbul, Balıkesir, Antalya and Hatay provinces between March and April 2023. Online data was collected from participants via Google Forms. 56.7% (n=17) of dietitians and 54.4% (n=68) of their clients use collagen (P&gt;0.05). While 36.7% (n=11) of dietitians said, it was beneficial for the skin, 23.3% (n=7) used it for weight control and digestive regulation, 38.4% (n=48) said it was beneficial for the skin and 34.4% (n=43) for joint density and pain relief. There was also no statistically significant difference (P&gt;0.05) between dietitians' and clients' information about collagen use. However, while 17.5% (n=3) of dietitians were concerned about the reliability, certification, and brand of collagen, 22.1% (n=15) of consumers were concerned about its reliability. In addition, the opinions of the dietitians and clients participating in the study regarding the use of collagen were not found to be statistically significant (P&gt;0.05).

Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.

With increasing life expectancy, the quest for skin rejuvenation has gained prominence among individuals of diverse age groups. The popularity of nutricosmetics, notably dietary supplements, has garnered significant attention in recent years. Many scientific investigations have amassed compelling evidence highlighting the positive impact of hydrolyzed collagen supplementation in mitigating the visible signs of skin aging.This study aims to know the powerful effect of hydrolyzed collagen on the skin. This research method is to conduct a systematic review followed by a meta-analysis of the clinical trial focusing on randomized, double-blind, and controlled trials that examined the oral consumption of hydrolyzed collagen and reported outcomes related to skin aging, wrinkles, moisture levels, elasticity, and firmness. The selected articles from CENTRAL, PubMed, Google Scholar, and ScienceDirect databaseswere published from 2017 to 2023.The subsequent meta-analysis, comprising 14 distinct studies and a collective cohort of 967 participants, revealed encouraging findings favoring hydrolyzed collagen supplementation. It consistently demonstrated substantial enhancements in skin moisture levels and elasticity compared to the placebo group, a trend robustly corroborated by subgroup analysis. These compelling findings underscore the effectiveness of a 12-week regimen of hydrolyzed collagen supplementation in revitalizing the skin by augmenting its hydration and elasticity.

Snakehead Fish Extract in Increasing Skin Collagen &amp; Fibroblasts

This study aim is to gain a deeper understanding of the mechanisms by which snakehead fish extract affects the skin, opening doors for the development of more effective and natural skincare products. The study employs a systematic literature review method using PRISMA strategy, identifying 156 relevant articles through platforms such as PubMed, Google Scholar, Scopus, SINTA, spanning from 2018 to 2023. Findings encompass increased VEGF production and NO levels with snakehead fish extract dosages, wounds healing potential of honey and snakehead fish skin combination in hydrogel formulations, increased fibroblast counts, reduced skin erythema, and decreased wound crust formation. Additionally, marine collagen exhibits promise in skin healing and bone repair. Collagen supplements, whether oral or topical, also prove beneficial in delaying skin aging. The study reveals crucial insights into the potential of snakehead fish extract in skincare and wound healing, supporting the development of more effective and natural skincare products.

The Collagen Synthesis Response to an Acute Bout of Resistance Exercise Is Greater when Ingesting 30 g Hydrolyzed Collagen Compared with 15 g and 0 g in Resistance-Trained Young Men

BackgroundResistance exercise (RE) stimulates collagen synthesis in skeletal muscle and tendon but there is limited and equivocal evidence regarding an effect of collagen supplementation and exercise on collagen synthesis. Furthermore, it is not known if a dose–response exists regarding the effect of hydrolyzed collagen (HC) ingestion and RE on collagen synthesis. ObjectiveTo determine the HC dose–response effect on collagen synthesis after high-intensity RE in resistance-trained young men. MethodsUsing a double-blind, randomized crossover design, 10 resistance-trained males (age: 26 ± 3 y; height: 1.77 ± 0.04 m; mass: 79.7 ± 7.0 kg) ingested 0 g, 15 g, or 30 g HC with 50 mg vitamin C 1 h before performing 4 sets’ barbell back squat RE at 10-repetition maximum load, after which they rested for 6 h. Blood samples were collected throughout each of the 3 interventions to analyze procollagen type Ⅰ N-terminal propeptide (PINP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX) concentration, and the concentration of 18 collagen amino acids. ResultsThe serum PINP concentration × time area under the curve (AUC) was greater for 30 g (267 ± 79 μg·L−1·h) than for 15 g (235 ± 70 μg·L−1·h, P = 0.013) and 0 g HC (219 ± 88 μg·L−1·h, P = 0.002) but there was no difference between 0 and 15 g HC (P = 0.225). The AUCs of glycine and proline were greater for 30 g than for 15 and 0 g HC (P < 0.05). Plasma β-CTX concentration decreased from −1 to +6 h (P < 0.05), with no differences between interventions. ConclusionsIngesting 30 g HC before high-intensity RE augments whole-body collagen synthesis more than 15 g and 0 g HC in resistance-trained young males.

Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes—A Quasi-Randomized Trial

Athletic injuries are commonly implicated in the development of early osteoarthritic (EOA) changes in the knee. These changes have a significant impact on athletic performance, and therefore the early detection of EOA is paramount. The objective of the study is to assess the impact of different interventions on individuals with EOA, particularly focusing on recreational athletes. The study aims to evaluate the effectiveness of three treatment groups in improving various aspects related to knee EOA, including pain, range of motion, strength, and function. A study was undertaken with 48 recreational athletes with EOA who were assigned to one of three groups by the referring orthopedic surgeon: collagen (Col), exercise (Ex), or collagen and exercise (ColEx) groups. All the participants received their respective group-based intervention for 12 weeks. Visual analog scale (VAS), knee flexion range of motion (ROM) knee flexors and extensors strength, and KOOS were assessed at baseline, and after 4 weeks, 8 weeks, and 12 weeks of intervention. VAS for activity improved in all treatment groups, with no difference between groups. The between-group analysis for knee ROM revealed a significant difference (p = 0.022) in the Col vs. Ex group at 12 weeks. The knee flexor and extensor strength and the KOOS scores improved considerably in the Ex and the ColEx group (p &lt; 0.05) at 12 weeks. Exercise therapy improved pain, strength and function in subjects with EOA, whereas the association of collagen seems to have accentuated the effects of exercise in bringing about clinical improvements.

The Potential Benefic Effect of Nicotinamide Riboside in Treating a Murine Model of Monoiodoacetate-Induced Knee Osteoarthritis.

Knee osteoarthritis (KOA), one of the most common orthopedic disorders concerning the adult population worldwide, is a condition characterized by progressive destruction of the articular cartilage and the presence of an inflammatory process. The aim of our study was to assess whether nicotinamide riboside (NR), a popular anti-aging supplement, can reduce the rate of cartilage destruction and alleviate the inflammatory response compared to the commonly prescribed collagen supplement in a murine monoiodoacetate (MIA)-induced KOA model. Twenty Wistar rats were randomly assigned to 4 groups: sham (S), MIA and NR, MIA and hydrolyzed collagen (HC), and MIA. At the end of the experiment, the right knees and blood samples were collected for histological assessment and biochemical evaluation of nitric oxide, malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase, myeloperoxidase, and tumoral necrosis factor-alpha (TNF-α). The study determined that the treatment with NR in a similar dose with HC decreased blood/serum levels of oxidative stress biomarkers and the histological lesions in almost the same manner. The present findings suggest that NR may exhibit chondroprotective and anti-inflammatory effects in MIA-induced KOA in rats.

Effects of Collagen and Exercise on Tendon Properties and Pain: A Critically Appraised Topic.

Achilles tendon ruptures are prevalent and devastating injuries that require the need for extensive rehabilitation. The methods for preventing these injuries vary between different exercise methods and nutritional supplementation. Although proven effective for decreasing pain and increasing tendon properties, the influence of these 2 methods in combination has not yet been evaluated. Does exercise combined with collagen supplementation improve Achilles tendon structural and mechanical properties and diminish subsequent patient-reported pain compared with exercise alone in adults? Exercise training, including eccentric training protocols and concentric resistance training protocols, combined with collagen supplementation influence Achilles tendon properties and subsequent patient-reported pain compared with exercise alone. Evidence supports that collagen along with exercise training has a significant influence on pain mitigation, augmented cross-sectional area, and tendon thickness, but may have little to no influence on tendon stiffness and microvascularity compared with exercise alone. Further research is needed to determine the effects of combined methods on various populations. Collectively, the body of evidence included to answer the clinical question aligns with the strength of recommendation of A.

A Pilot Study of the Effects of Collagen vs. Whey Protein Supplementation on Delayed Onset Muscle Soreness in Healthy Individuals

Introduction: Delayed onset muscle soreness (DOMS) is a common condition characterized by muscle stiffness, pain, and inflammation following intense or unaccustomed exercise. Despite its prevalence, the underlying mechanisms of DOMS remain unclear. This study aimed to investigate the effects of collagen supplementation on tissue repair and pain associated with DOMS in exercise-trained individuals. Methods: Fourteen exercise-trained men (n=7) and women (n=7) were enrolled in a randomized, counterbalanced, crossover trial. Participants were assigned to either a whey protein group (n=8) or a collagen protein group (n=6). Each participant consumed 40g of their respective protein supplement daily for four consecutive days. Peak soreness was assessed using self-reported ratings and algometer measurements. Statistical analysis included independent samples t-tests and Levene's test for equality of variances. Results: The analysis revealed no significant difference in peak soreness between the whey protein and collagen protein groups at the 24-hour time point (t(12) = 1.33, p = 0.208). Both groups experienced a decrease in peak soreness over the 24-hour period, but the reduction was not statistically different between the groups. No significant differences were observed in other variables measured. Conclusions: These findings suggest that collagen protein supplementation did not significantly reduce peak soreness associated with DOMS compared to whey protein supplementation in exercise-trained individuals. While collagen supplementation has shown potential benefits in tissue repair and joint health, further research is needed to explore its specific effects on DOMS. Larger studies with different dosages and participant populations are warranted to obtain a more comprehensive understanding of collagen's impact on muscle soreness and tissue repair.

Development of a new method for the determination of 4-hydroxyproline as a measurement of collagen content in meat products and dietary supplements by cyclodextrin-assisted electrokinetic chromatography

The rise in consumption of ultra-processed meat and dietary collagen supplements challenges food quality control. 4-hydroxyproline stands out as collagen signature amino acid, and its determination is a well-known way to estimate collagen content, although for this measurement, the majority of the methods require a mandatory derivatization step. Therefore, this study aimed to develop an innovative method using cyclodextrin-assisted electrokinetic chromatography with indirect UV detection to determine 4-hydroxyproline for collagen monitoring in dietary supplements and meat products. Separations were performed in fused silica capillaries, at 12.5 °C, detection at 220 nm, 30 kV voltage, and hydrodynamic injection. Background electrolyte consisted of histidine 25 mmol L-1, butylamine 180 mmol L-1, and β-cyclodextrin 10 mmol L-1 at pH 11.4. Samples were hydrolyzed with sulfuric acid, and their removal was accomplished by simultaneous neutralization/precipitation reactions using strontium carbonate. Validation assured method detectability, accuracy (recoveries 88% - 102%), and precision (CV < 7%). Dietary supplements and meat products were successfully evaluated, indicating that this method is a feasible quality control alternative.

A QUALITATIVE ASSESSMENT OF THE LABELING INFORMATION OF COLLAGEN-CONTAINING FOOD SUPPLEMENTS

The use of collagen dietary supplements (CDS) has increased dramatically, creating a large market for these products. With so many options available, it is important for consumers and medical professionals to be well-informed about the composition of these supplements. The aim of this study was to compare the information provided on the labels of CDS with science-based literature. The study conducted an electronic search of randomized, double-blind, control, and pilot studies, which all evaluated the use of oral native or hydrolyzed CDS. All studies were searched in PubMed, and had to be published in English between 2009-2022, August in PubMed. After the initial search, 33 were used for analysis. These studies were then compared to 147 CDS labels registered with the Food Veterinary Service (FVS) in Latvia. The results showed that while studies confirm the benefits of CDS for health, the labels registered in FVS often lack important information about the collagen source, dosage, and duration of use. This results in a significant frequency of errors and potential misuse compared to current scientific knowledge. This makes it challenging for consumers and medical professionals to make informed decisions when purchasing and using collagen supplements.

Collagen Supplementation

Collagen Supplementation

ORAL COLLAGEN AND AGING

ABSTRACT&#x0D; Background and Objective: Skin is a barrier that protects the body from the outer environtment and has a cosmetic function. Aging is biological process that marked by deterioration of physiological function of the body. Collagen has responsible in stability and strength of body tissues. In recent years, oral collagen supplementation has become popular because it’s distributed to peoples as an anti aging therapy. The aim of this study is investigating that there is effect of oral collagen in order to prevent aging. Methods: I reviewed studies about oral collagen and aging. Studies were published within five years priors to 2020. I searched studies about them using keywords including aging, anti aging, oral collagen, and collagen. Conclusion: Oral collagen plays an important role in order to prevent aging. It can be absorbed effectively because the most form of oral collagen is hydrolyzed collagen, so our body doesn’t need to change it to a smaller molecule before use it. Oral collagen also doesn’t have side effects to our body. Therefore, it can be used to prevent aging together with controlling of intrinsic and extrinsic factors that contributing in skin aging.&#x0D; Keywords: aging, oral collagen, collagen.