Collagen-calcium Phosphate Research Articles

Formation of mineralized scar tissue induced by implants containing collagen-calcium phosphate gel

The ability of a collagen-calcium phosphate gel to induce physiologic closure of subcutaneous polyethylene tube implants was tested. The openings of several tubes that had been filled with the gel were occluded by scars of mineralized connective tissue. Differentiation of cells into palisading fibroblasts and elaboration of a linear collagen matrix at the tissue-gel interface was seen.