Open innovation is a concept of collaboration of ideas, knowledge, and resources that originates from within the organization and involves external organizations. University-industry collaboration is a factor driving innovation and competitiveness. Most research on interactions between universities and industry concentrated on the industrial side meanwhile, universities, as knowledge producers, play a vital role in creating an open innovation ecosystem that encourages realizing innovations that benefit society. Therefore, the problem raised in this research is how university collaboration can support open innovation. This research aims to identify research trends, the latest technologies, and inter-university collaboration frameworks that can support open innovation. The methodology used is Kitchenham's Systematic Literature Review (SLR) and bibliometric. SLR consists of Identification Study, Selection Studies, Quality Assessment, Data Extraction and Study Synthesis. From the SLR stages, 21 papers published between 2019 and 2023 were obtained. Synthesis and additional literature review were carried out to identify trends, technologies, and frameworks related to the topic comprehensively. In terms of trend, based on the application bibliometric, it was found that there was an increase in the number of publications and the top list of open innovation journals. University collaboration in open innovation more frequently takes place in the UK, and the industries mostly involved are small-medium enterprises. Quantitative research methodology and data analyses, comprising of hypothesis test, regression test, and descriptive statistics, are mostly preferred. Meanwhile, descriptive data analysis is the most common means of qualitative data analysis. Numerous suggestions on topics for future research were also identified. In addition, data analysis using machine learning survival data is identified as a novelty among data analysis methods. Technology transfer and the use of digital platforms may support open innovation processes, and the use of blockchain technology may promote digital platforms development. Seven domains form the framework for university collaboration in open innovation, namely Social Behavior, People, Process, Organization, Environment, Technology, and Performance. The findings of trends, technologies, and frameworks in this research may serve as a foundation for research on similar topics, and the identified framework domains could serve as framework components that might be used by universities to collaborate with partners in implementing open innovation processes. The research have contributes to knowledge management theoretically and practically. Theoretically, open innovation can expand the knowledge base by supporting the concept that knowledge and expertise can be found outside organizational boundaries. Practically, it can enrich knowledge management practices by emphasizing the importance of utilizing digital platform technology in supporting knowledge management sourced from external knowledge and collaboration services in the open innovation process.