Training and learning methods for engineering students, in the disciplines of product design and manufacturing, are becoming more difficult and complex since they have to integrate theoretical technical knowledge, skills in computer-aided applications (CAx) and skills in collaborative work practices. Product Lifecycle Management (PLM) tools support structured collaborative practices and CAx supports engineering content creation. Both types of software applications are key in the Industry 4.0 development. They also evolve over time, incorporate new functionalities, and change their graphical user interface (GUI), adding complexity to the learning process. Traditionally, engineering education addresses the learning of CAx and PLM tools separately, hindering a holistic learning experience to the students. This communication presents a structured integrated vision of these tools and their learning. Project-Based Learning (PBL) is proposed as a learning approach suitable to provide a learning experience that facilitates the development of Industry 4.0 skills and competences.