Coincidence Detection Circuit Research Articles

Evaluation of dual-ended readout GAGG-based DOI-PET detectors with different surface treatments.

Parallax error is a major issue in small animal positron emission tomography (PET) scanners which are used in preclinical studies or detailed scanning of human organs. Several methods have been proposed and investigated to reduce this radial artifact in PET images by estimating the depth of interaction (DOI) of 511-keV photons in the crystal. Among all, the dual-ended readout method seems to be very simple and effective as it does not have any fabrication and readout complications. In the past, some studies suggested that increasing the roughness of crystal lateral surfaces improves DOI resolution. In this paper, this was experimentally examined for four Ce:GAGG crystals with different surface structures. Four 1.2×1.2×20mm3 GAGG crystals with following surface treatment were examined: polished with optical finishing, fine grinding (using a fine surface grinding machine), fine cutting (no treatment), and coarse cutting (no treatment). These crystals were coupled individually to two SiPMs for dual-ended readout and placed in a coincidence detection circuit for electronic collimation of 511keV incidents. The crystals were compared in terms of energy response and DOI estimation capability. DOI function for each crystal was extracted and FWHM DOI resolution was calculated. DOI resolution for the polished crystal varied in the range of 0.54-4.14mm throughout the length of the crystal due to its nonlinear DOI function. The fine grinding crystal showed a linear DOI function within the dynamic range of (-0.75, 0.75), and its DOI resolution varied in the range of 1.24-1.50mm (1.37±0.13mm DOI resolution). The fine-cut crystal had almost a linear DOI function and a wider dynamic range of (-0.85, 0.85) and therefore the best performance with 1.2±0.08mm DOI resolution. However, for the crystal with the roughest surface (coarse-cut crystal), even though the dynamic range expanded to (-0.95, 0.95), its DOI function became nonlinear resulting in 1.24±0.28mm DOI resolution. This means there is an optimum surface roughness to provide the crystal with the best DOI capability. The pulse-height spectrum measured at each depth was used as a measure to compare the energy performance of the four crystals. The photopeak of 511keV was observed for all depths, all crystals. The photopeak position for the coarse-cut crystal had extensive depth dependency which results in poorer energy resolution unless the energy window is calibrated for each depth. This variation of photopeak for the fine-cut and fine grinding crystals was comparable with that of polished crystal. This paper reports 1.2±0.08mm FWHM DOI resolution for a fine-cut unpolished crystal. This resolution is as narrow as the crystal width, resulting in the complete elimination of parallax error in PET images. Results suggest that there is an optimum roughness for the best performance of the dual-ended method and further increase in the roughness, degrades DOI resolution. Thanks to the high light yield of GAGG, the energy performance of the fine-cut crystal is acceptable, and the depth dependency of the spectrum is negligible.

Post-Measurement Adjustment of the Coincidence Window in Quantum Optics Experiments

We report on an electronic coincidence detection circuit for quantum photonic applications implemented on a field-programmable gate array (FPGA), which records each the time separation between detection events coming from single-photon detectors. We achieve a coincidence window as narrow as 500 ps with a series of optimizations on a readily-available and affordable FPGA development board. Our implementation allows real-time visualization of coincidence measurements for multiple coincidence window widths simultaneously. To demonstrate the advantage of our high-resolution visualization, we certified the generation of polarized entangled photons by collecting data from multiple coincidence windows with minimal accidental counts, obtaining a violation of the Clauser-Horne-Shimony-Holt (CHSH) Bell inequality by more than 338 standard deviations. Our results have shown the applicability of our electronic design in the field of quantum information.

Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy

Evidence is lacking as to how developing neurons integrate mitogenic signals with microenvironment cues to control proliferation and differentiation. We determine that the Siah2 E3 ubiquitin ligase functions in a coincidence detection circuit linking responses to the Shh mitogen and the extracellular matrix to control cerebellar granule neurons (CGN) GZ occupancy. We show that Shh signaling maintains Siah2 expression in CGN progenitors (GNPs) in a Ras/Mapk-dependent manner. Siah2 supports ciliogenesis in a feed-forward fashion by restraining cilium disassembly. Efforts to identify sources of the Ras/Mapk signaling led us to discover that GNPs respond to laminin, but not vitronectin, in the GZ microenvironment via integrin β1 receptors, which engages the Ras/Mapk cascade with Shh, and that this niche interaction is essential for promoting GNP ciliogenesis. As GNPs leave the GZ, differentiation is driven by changing extracellular cues that diminish Siah2-activity leading to primary cilia shortening and attenuation of the mitogenic response.

Precise Frequency Comparison System Using Phase Coincidence Demarcation

The precise frequency comparison system is of great importance in many applications. A frequency comparison method based on the phase coincidence demarcation (PCD) is proposed, and a frequency comparison system based on the proposed method is realized. The proposed method solves the uncertainty problem of the phase coincidence detection circuit by using two analog-to-digital converter (ADC) chips to demarcate the phase coincidence points. The test results indicate that the precision of the realized frequency comparison system is 10−16 (Allan deviation) at 1000 s.

Out of balance: how a binaural coincidence detection circuit responds to unilateral deafferentation.

Out of balance: how a binaural coincidence detection circuit responds to unilateral deafferentation.

Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.

Binaural excitatory inputs to coincidence detection neurons in nucleus laminaris (NL) play essential roles in interaural time difference coding for sound localization. Here, we show that the two excitatory inputs are physiologically nearly completely segregated. Synaptic integration shows linear summation of EPSPs, ensuring high efficiency of coincidence detection of the bilateral excitatory inputs. We further show that the two excitatory inputs to single NL neurons are symmetrical in synaptic strength, kinetics and short-term plasticity. Modulation of the EPSCs by metabotropic glutamate receptors (mGluRs) is identical between the two excitatory inputs, maintaining balanced bilateral excitation under neuromodulatory conditions. Unilateral hearing deprivation reduces synaptic excitation and paradoxically strengthens mGluR modulation of EPSCs, suggesting activity-dependent anti-homeostatic regulation, a novel synaptic plasticity in response to sensory manipulations. Neurons in the avian nucleus laminaris (NL) receive bilateral excitatory inputs from the cochlear nucleus magnocellularis, via morphologically symmetrical dorsal (ipsilateral) and ventral (contralateral) dendrites. Using in vitro whole-cell patch recordings in chicken brainstem slices, we investigated synaptic integration and modulation of the bilateral inputs to NL under normal and hearing deprivation conditions. We found that the two excitatory inputs onto single NL neurons were nearly completely segregated, and integration of the two inputs was linear for EPSPs. The two inputs had similar synaptic strength, kinetics and short-term plasticity. EPSCs in low but not middle and high frequency neurons were suppressed by activation of group I and II metabotropic glutamate receptors (mGluR I and II), with similar modulatory strength between the ipsilateral and contralateral inputs. Unilateral hearing deprivation by cochlea removal reduced the excitatory transmission on the deprived dendritic domain of NL. Interestingly, EPSCs evoked at the deprived domain were modulated more strongly by mGluR II than at the counterpart domain that received intact input in low frequency neurons, suggesting anti-homeostatic regulation. This was supported by a stronger expression of mGluR II protein on the deprived neuropils of NL. Under mGluR II modulation, EPSCs on the deprived input show transient synaptic facilitation, forming a striking contrast with normal hearing conditions under which pure synaptic depression is observed. These results demonstrate physiological symmetry and thus balanced bilateral excitatory inputs to NL neurons. The activity-dependent anti-homeostatic plasticity of mGluR modulation constitutes a novel mechanism regulating synaptic transmission in response to sensory input manipulations.

New Approach to Generate Second Signal

A phase coincidence phenomenon between two arbitrary frequency signals is a periodic phenomenon. One application of this phenomenon is a new method to generate a stable time signal. Using two frequency signals with a certain frequency difference and a phase coincidence detection circuit to detect the phase coincidence signal of them, one can get a periodic coincidence signal. And then moving the phases of the two frequency signals properly, one can get a coincidence signal synchronizing with a standard time signal. The advantage of the new method is the second signal generated by it is easy to transmit and comparison with high resolution.

Control of a Depolarizing GABAergic Input in an Auditory Coincidence Detection Circuit

Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus magnocellularis (NM) and GABAergic inhibition from the ipsilateral superior olivary nucleus. Here, we study metabotropic glutamate receptor (mGluR)- and GABAB receptor (GABABR)-mediated modulation of synaptic transmission in NL neurons. Gramicidin-perforated recordings from acute brain stem slice preparations showed that the reversal potential of the GABAergic responses in NL neurons was more depolarized than the spike threshold. Activation of the GABAergic input produced a mix of inhibitory and excitatory actions in NL neurons. The inhibitory action is known to be critical in improving the acuity of temporal processing of sounds. The excitatory action, however, would reduce the phase locking fidelity of NL neurons in response to their excitatory inputs from the NM. We show that activation of presynaptic mGluRs or GABABRs by either exogenous agonists or synaptically released neurotransmitters reduced the GABAergic responses, preventing the excitatory action of GABA while leaving the inhibitory action intact. Unlike most CNS synapses, the glutamatergic transmission in the NL was not modulated by either mGluRs or GABABRs, indicating that fixed (nonmodulatory) excitatory inputs to the NL may be optimal for coincidence detection. This study contributes to our understanding of how selective neuromodulation is achieved to suit a particular function of neuronal circuits in the brain.

Digital coincidence detection: a scanning VLSI implementation

The authors have implemented a modular digital coincidence detection circuit in VLSI, which drastically reduces the size and increases the performance of the coincidence detection logic required in a PET (positron emission tomography) scanner. Important acquisition features contained within this integrated solution include: (1) prompt and delayed processing channels for each event-pair, with programmable coincidence time windows; (2) event time difference mode, which allows for a fast and accurate system timing calibration algorithm; (3) programmable axial event acceptance, which provides acquisition flexibility from conventional 2-D through fully 3-D sinogram sets; and (4) programmable transaxial field of view, which provides an electronic collimator to ignore event-pairs outside of the desired field of view. The modularity of the design allows it to be used on various system geometries. >

Serial measurements of positron-emitting isotope activity in rat brain.

This report describes the construction and performance characteristics of a device capable of making rapid serial measurement of rat brain radioactivity following the administration of a positron emitting isotope. Two bismuth germanate oxide (BGO) scintillation detectors in a coincidence detection circuit are used to achieve the necessary degree of collimation. Data from the device can be used to characterize cerebral biochemical and physiological processes using computer-assisted mathematical models.