You have accessJournal of UrologyTransplantation & Vascular Surgery: Renal Transplantation & Vascular Surgery III (MP59)1 Apr 2020MP59-15 TUMOUR-BEARING KIDNEYS AS POTENTIAL TRANSPLANT DONORS : A NATIONAL ONLINE UK SURVEY Matthew Trail*, Ali Thwaini, Wesam Elbaroni, Aisling Courtney, Tim Brown, Ghulam Nabi, David Cranston, David Nicol, and Zeeshan Aslam Matthew Trail*Matthew Trail* More articles by this author , Ali ThwainiAli Thwaini More articles by this author , Wesam ElbaroniWesam Elbaroni More articles by this author , Aisling CourtneyAisling Courtney More articles by this author , Tim BrownTim Brown More articles by this author , Ghulam NabiGhulam Nabi More articles by this author , David CranstonDavid Cranston More articles by this author , David NicolDavid Nicol More articles by this author , and Zeeshan AslamZeeshan Aslam More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000928.015AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The deficiency in available donor organs for patients with end-stage renal failure (ESRF) awaiting renal transplantation is an increasingly important global health issue. In the UK, 4757 adult patients were awaiting renal transplant as of 2018. Meanwhile, 3272 transplant procedures were performed that year and 1200 patients died whilst awaiting transplant. To address the deficiency in donor organs, novel organ donor sources have been suggested and trialled - including transplantation of kidneys with small renal tumours (cT1) after ex-vivo tumour excision and histopathology confirming benign or low grade disease with clear margins. According to the British Association of urological Surgeon’s (BAUS) national audit, up to 7700 nephrectomy operations are performed each year in the UK, 2900 of which are for cT1 renal cancer. In existing studies which have trialled this concept, reported outcomes were positive, with neglible tumor recurrence and a high graft and patient survival. We explored the acceptability amongst UK clinicians of the consideration of utilising cT1 tumour-bearing kidneys as potential organ donors after ex-vivo tumour excision with pathology confirming benign or low grade disease and clear margins. METHODS: An online survey of UK urologists with an interest in renal surgery, transplant surgeons and transplant nephrologists was carried out between November and December 2018 to establish clinician attitude towards accepting such kidneys for transplantation in a carefully-selected group of dialysis-dependent patients which includes elderly patients, those in whom dialysis is poorly tolerated, those having difficulties finding a match or those with significant comorbidity. Reported outcomes were positive, with a high graft and patient survival. RESULTS: In all, 110 urologists, 50 transplant surgeons and 70 nephrologists were approach, with a response rate of 57%, 66% and 63% respectively. We identified six centres within the UK currently performing this procedure.Forty five (73%), 20(55%) and 30(91%) of the urologists, nephrologists and transplant surgeons respectively supported the concept of using these kidneys for selected transplant recipients. However, questions were raised – with some respondents with some expressing concern regarding the potential for higher recurrence risk in immunosuppressed post-transplant patients. CONCLUSIONS: This survey has demonstrated an interest for this concept amongst clinicians directly involved with renal cancer surgery or renal transplantation throughout the UK. Whilst associated ethical and logistical challenges must be carefully considered, widespread adoption of this concept may have potential to reduce waiting list burden and increase life expectancy in a specific cohort of patients awaiting renal transplantation. In light of the responses to this survey and existing studies which have demonstrated positive outcomes, there may be potential to establish a national clinical trial to investigate this concept further. Source of Funding: Nil © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e886-e886 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Matthew Trail* More articles by this author Ali Thwaini More articles by this author Wesam Elbaroni More articles by this author Aisling Courtney More articles by this author Tim Brown More articles by this author Ghulam Nabi More articles by this author David Cranston More articles by this author David Nicol More articles by this author Zeeshan Aslam More articles by this author Expand All Advertisement PDF downloadLoading ...
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