Introduction: Medical practice, particularly in Neurology, is often influenced by cognitive biases that can compromise diagnostic and therapeutic accuracy, leading to significant patient consequences. Clinical reasoning strategies are fundamental, yet the complexity of these processes is frequently underestimated. Understanding these strategies is crucial to ensure accurate diagnoses and effective treatments, thereby reducing clinical errors and optimizing patient outcomes. Despite extensive literature on cognitive biases, there is a need for a systematic synthesis addressing the peculiarities of neurological clinical reasoning, considering heuristics (mental shortcuts or rules of thumb that simplify decision-making) and hermeneutics (the theory and methodology of interpretation, especially of textual and symbolic content). Objectives: To review and systematize the main clinical reasoning strategies in Neurology, highlighting common biases and proposing methods to improve diagnostic and therapeutic accuracy. Methodology: A comprehensive literature review focusing on familiarity biases, Dual Process Theory, and heuristics (anchoring, availability, and representativeness). Additionally, the application of hermeneutics in hypothesis formulation and the importance of understanding the patient as a complex system were analyzed. Results: Specialized neurologists often rely on heuristics, which means a cognitive shortcut. Recognizing this process can mitigate anchoring and availability biases. The hermeneutic approach, on the other hand, is essential for interpreting variables in the patient’s context, integrating historical and social aspects. Conclusion: Understanding clinical reasoning processes and systematically teaching these strategies are crucial to enhancing the efficiency and effectiveness of clinical decision-making, reducing diagnostic errors, and improving patient outcomes.
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