Cognitive Level Research Articles

The Neural Specificity of Interference Resolution in Phonological, Semantic, and Visual Domains at Different Ages.

The question of whether cognitive control is specific to certain domains or domain-general remains an extensively debated question at both cognitive and neural levels. This study examined the neural substrates associated with resistance to interference (RI) in phonological, semantic, and visual domains by using strictly matched tasks and determining the domain-general or domain-specific manner in which aging affects the neural substrates associated with RI. In an fMRI experiment, young and older participants performed a similarity judgment task with phonological, semantic, or visual interference buildup. For both age groups, domain-specific RI effects were observed at the univariate level, with increased involvement in the phonological domain of the right angular gyrus and the right lingual gyrus, in the semantic domain of the bilateral inferior frontal gyrus, the bilateral superior parietal and angular gyri and the left middle temporal gyrus, and in the visual domain of the middle/superior frontal gyri and occipital gyri. At the multivariate level, although RI effects could be decoded from neural patterns in the bilateral inferior frontal gyrus for all domains and age groups, between-domain prediction of RI conditions was associated with Bayesian evidence for the null hypothesis. This study supports the domain specificity of neural substrates associated with RI while stressing its age independency.

Comparing the effectiveness of individual occupation-based reminiscence therapy at home and in a dementia care centre on cognitive function in older adults with mild dementia: a pilot randomised controlled trial.

The need for research on individual home therapies to promote continued community-dwelling among older adults with mild dementia is growing. This study aimed to compare the effects of individual occupation-based reminiscence therapy at home (IOBRT-H) and individual occupation-based reminiscence therapy in a dementia care centre (IOBRT-DCC) on cognitive function, depression, and instrumental activities of daily living (IADL) among community-dwelling older adults with mild dementia. This study was a randomised controlled trial. Twenty-six community-dwelling older adults with mild dementia were randomised to the IOBRT-H (n = 13) and IOBRT-DCC (n = 13) groups. The intervention was conducted for 10 weeks, with one session a week and each session lasting 60 min for both groups. Cognitive function was assessed using the Allen Cognitive Level Screen (ACLS), depression with the short form of the Geriatric Depression Scale Korean version (SGDS-K), and IADL using the Seoul-Instrumental Activities of Daily Living (S-IADL). Both the IOBRT-H and IOBRT-DCC groups showed significant improvements in ACLS scores (P < 0.01 and P < 0.01, respectively). The SGDS-K score decreased only in the IOBRT-H group (P < 0.01). Between the groups, the IOBRT-H group had significantly greater improvements in both ACLS and SGDS-K scores than the IOBRT-DCC group (P < 0.05 and P < 0.05, respectively). This study's results indicated the potential for applying IBORT-H as an intervention to improve cognitive function and reduce depression in community-dwelling older adults with mild dementia. We expect the findings of this study to serve as useful foundational data for developing home-visiting cognitive programs.

LLM-generated competence-based e-assessment items for higher education mathematics: methodology and evaluation

In this article, we explore the transformative impact of advanced, parameter-rich Large Language Models (LLMs) on the production of instructional materials in higher education, with a focus on the automated generation of both formative and summative assessments for learners in the field of mathematics. We introduce a novel LLM-driven process and application, called ItemForge, tailored specifically for the automatic generation of e-assessment items in mathematics. The approach is thoroughly aligned with the levels and hierarchy of cognitive learning objectives as developed by Anderson and Krathwohl, and takes specific mathematical concepts from the considered courses into consideration. The quality of the generated free-text items, along with their corresponding answers (sample solutions), as well as their appropriateness to the designated cognitive level and subject matter, were evaluated in a small-scale study. In this study, three mathematical experts reviewed a total of 240 generated items, providing a comprehensive analysis of their effectiveness and relevance. Our findings demonstrate that the tool is proficient in producing high-quality items that align with the chosen concepts and targeted cognitive levels, indicating its potential suitability for educational purposes. However, it was observed that the provided answers (sample solutions) occasionally exhibited inaccuracies or were not entirely complete, signalling a necessity for additional refinement of the tool's processes.

Scientific Skills Present in Chilean School Textbooks from First to Fourth Grade in Natural Sciences

Objective: This research focused on identifying and classifying the scientific skills present in Chilean school textbooks of Natural Sciences from the first to the fourth year of Basic Education. Theoretical Framework: We sought to determine their presence, frequency, cognitive level and types of skills, comparing them with curricular documents and UNESCO declarations on the subject. Method: The study, descriptive in nature, employed the integrative method, using document analysis to compile quotations, patterns of behavior and categories. For quantitative aspects, descriptive statistics were used, analyzing by course and thematic units. Results and Discussion: It was found that the most promoted skills were observation and explanation, fundamental for scientific learning. Scientific skills were identified at all educational levels, varying in frequency. Third and fourth year showed a greater frequency and variety of higher cognitive level skills, although some, such as creating, evaluating, reflecting and imagining, did not have the expected frequency. The lower cognitive skills did not show significant differences between educational levels. The scientific skills present in the school texts coincide in general with those declared in the Curricular Bases and by UNESCO, both in type and educational level. Implications of the investigation: the investigation implies that the scientific skills that declare the Curriculum Bases and scientific literature are promoted, mostly, in school texts on Natural Sciences for basic education, verifying correspondence between the documents. Originality/Value: the study contributes to literature by contributing new knowledge to the state of affairs of the knowledge of Natural Sciences in basic education, as well as highlighting the need to promote more creativity and imagination in school texts. At the same time, the results will be an input for teachers to pay more attention to higher-level scientific processes.

2022 개정 특수교육 기본 교육과정 수학과 성취기준 분석: Bloom의 신교육목표분류학에 기초하여

Objectives This study aims to provide implications for the achievement standards of the basic curriculum for mathematics in the 2022 Revised Special Education Basic Curriculum by analyzing them based on Bloom's revised taxonomy of educational objectives. Methods To this end, a total of 182 mathematics achievement standards of the revised 2022 special education basic curriculum were analyzed for five grade groups and five mathematics areas based on Bloom's new taxonomy of educational objectives. Results First, the achievement standards for each grade were analyzed. As a result, among Bloom's knowledge dimensions in all grade groups, ‘factual knowledge’ was the highest with 104 (57.1%), and among the cognitive process dimensions, ‘Understanding’ was the highest with 89 (48.9%). A binary classification analysis of knowledge and cognitive process levels, the achievement standards for remembering factual knowledge were found in 55 achievement standards(30.2%). There were no achievement standards for ‘Meta-cognitive knowledge’, ‘Evaluation’, and ‘Create’. Second, as a result of analyzing the achievement standards by mathematics area, ‘Factual knowledge’ was the highest in the knowledge dimension with 45 achievement standards (48.9%) for numbers and operations, 28 (87.5%) for shapes, and 24 (92.2%) for measurement. ‘Conceptual knowledge’ was the highest with 12 (70.5%) in the regularity area and 9 (60%) in the data and probability area. In the cognitive process, ‘Remember’ was the highest with 29 (31.5%) in the number and calculation areas and 18 (56.3%) in the measurement areas was the highest with 17 achievement standards (65.3%), the regularity area with 7 achievement standards (41.1%), and the data and probability area with 9 achievement standards(60.0%). There were no achievement standards for ‘Meta-cognitive knowledge’, ‘Evaluation’, and ‘Create’. Conclusions Based on the results of this study, implications for the development of mathematics achievement standards of the basic curriculum for special education and suggestions for future research were made.

Analysis of the effect of CICARE communication nursing on the improvement of serum IL-10, IL-6, IL-4, IL-2 and lung function in outpatients with acute bronchitis

Abstract: OBJECTIVE: The objective of the study was to investigate the impact of CICARE communication nursing on the improvement of serum interleukin-10 (IL-10), interleukin-6 (IL-6), interleukin-4 (IL-4), and interleukin-2 (IL-2) and lung function in outpatients with acute bronchitis (AB). METHODS: One hundred and twenty suffers with AB who are treated in the outpatient department during Revised to 2021 to March 2023 are chosen and grouped according to the time of admission and different nursing practices. The control group consists of 60 patients from March 2021 to March 2022 who receive routine outpatient care; the experimental group consists of 60 patients from April 2022 to March 2023, and CICARE communication nursing is implemented additionally. Before and after intervention, the cognitive level of self-care knowledge, the level of peripheral blood inflammatory factors, and the improvement of lung function are compared. RESULTS: Before intervention, there were no remarkable differences in self-care knowledge cognition scores, peripheral blood inflammatory factors, and lung function levels between them (P &gt; 0.05). After intervention, the cognitive scores of treatment coordination, medication method, daily attention, diet, and activity in experimental groups are superior to control group (P &lt; 0.05). The levels of IL-10, IL-6, IL-4, and IL-2 in test groups are inferior to control group (P &lt; 0.05). Forced vital capacity, forced expiratory volume in 1 s, maximum air volume, and peak flow rate in test groups are superior to control group (P &lt; 0.05). CONCLUSION: CICARE communication nursing can improve the cognition level of self-care knowledge of patients with AB, reduce the inflammatory response of the body, and promote the recovery of lung function.

Effects of activity participation and cognitive levels on depression in middle-aged and older adults with chronic illness: a national cross-sectional study.

The world population is rapidly aging, and depression mainly affects middle-aged and older adults with chronic diseases and cognitive impairments. The sample for this study was obtained from the China Health and Retirement Longitudinal Study (CHARLS) public database. The sample size for inclusion was 12,767. There were 6,773 females and 5,994 males, with an overall low level of education. This study aims to provide a theoretical and practical reference basis for the clinical non-pharmacological treatment of depression in middle-aged and older adults (age ≥ 50 years) with chronic diseases. Additionally, the study seeks to promote the development of mental health interventions for middle-aged and older adults (age ≥ 50 years) with chronic diseases, ultimately enhancing the sense of well-being and quality of life for this demographic. Cognitive functioning and depressive symptoms of the study participants were assessed using the Mini-Mental State Examination Scale (MMSE) and the short version of the Center for Epidemiological Studies Depression Scale (CESD-10). Binary logistic regression results showed that among middle-aged and older adults (age ≥ 50 years) with chronic diseases, participation in physical activity [OR = 1.397; 95% CI (1.181-1.651); p < 0.05] was more effective than participation in social activities [OR = 0.997; 95% CI (0.924-1.076); p < 0.05] for preventing depression. Those with cognitive impairment [OR = 1.206; 95% CI (1.089-1.335); p < 0.05] were more likely to experience depression than those without cognitive impairment. Activity participation (physical activity and social activity) had a more significant effect on mild and moderate depression compared to no depression, and cognitive level had a more pronounced effect on moderate depression [OR = 1.491; 95% CI (1.278-1.740); p < 0.05] and major depression [OR = 2.231; 95% CI (1.282-3.884); p < 0.05]. Within the specific cohort of middle-aged and older adults (age ≥ 50 years) with chronic diseases, both activity participation and cognitive level exert a significant influence on the prevention and intervention of depression. Engagement in physical activity, participation in social activities, and enhanced cognitive functioning emerged as protective factors against depression. Therefore, the policy-maker should strengthen the prevention and treatment of depression in a comprehensive manner through the promotion of physical and social activities and the enhancement of cognitive level, so as to safeguard the mental health of middle-aged and older adults with chronic diseases.

The Study of National Identity in the Framework of Chinese Ethnopsychology

The population of the Chinese nation makes up a quarter of the total population of the globe. If studies of the self-consciousness of the Chinese nation are not conducted in world psychology, then a significant gap will appear in this field of knowledge. It is no exaggeration to say that the study of Chinese national identity plays an important role in the field of world psychology. The self-awareness of the Chinese nation at the cognitive level is manifested in a full understanding of the traditional cultures of various Chinese ethnic groups, a rational attitude to ethnic cultural differences and the constant improvement of cultural adaptability. The self-awareness of the Chinese nation on an emotional level manifests itself in the form of close exchanges and contacts between various ethnic groups, constantly reducing the psychological distance between these groups, forming complex and harmonious ethnic relations; The will and beliefs are manifested as the will and determination of all ethnic groups in the process of realizing the great renaissance of the Chinese nation. A complete understanding of the conceptual system of self-awareness of the Chinese nation from the point of view of ethnic psychology is of great importance for building a Chinese national community.

LINGUOCOGNITIVE AND LINGUOCULTURAL FOUNDATIONS OF THE PROCESSES OF TERMINOLOGIZATION IN MODERN KAZAKH AND TURKISH LANGUAGES

The intensification of the activity of the Kazakh language in accordance with its state status in all spheres of society, the renewal of its potential strengthened the connection of the language with the form of linguistic consumption, began to influence the requirements of everyday practice. This is evident from the active process of terminology creation in the social, economic, political, scientific and technical spheres. In addition, the core of the neonominational process, which created the interrelationships of language~ society, language~consciousness, language ~ culture, etc., is not only scientific and informational, but also cultural and social content. This is the basis for improving not only the quantitative, but also the qualitative level of modern language development. Therefore, the recognition of the influence of language and culture on each other in the form of new terms and the function of language as a unique means of transmitting culture within the framework of cultural representation is especially relevant. Based on this, new names and terms in the Kazakh language, which also serve as a unique feature of the cognitive level of language users, are considered in the article as a “linguistic picture of the world” in accordance with the process of updating the language. In this regard, the purpose of this article is to compare and characterize the linguocognitive and linguocultural foundations of terminologization processes in modern Kazakh and Turkish languages. The following methods were used in the course of the study: descriptive, comparative, cognitive, ethnolinguistic and conceptual. Also, to determine the cultural and national component structured in the mind of a native speaker in a terminologized word, diachronic, contrasting, definitive were used, and discursive analysis, connotative approach, and motivation methods were used to recognize the process of terminologization. The value of the research: by describing and showing the linguocognitive and linguocultural foundations of terminologization processes in modern Kazakh and Turkish languages, we contribute to the improvement and strengthening of the “Turkic world”. The linguistic data and conclusions presented in the article can be used as practical and theoretical material for research by students, undergraduates, doctoral students and young people studying at the faculties of Philology, Translation Studies, Oriental Studies and Turkology.

Automatic generation of physics items with Large Language Models (LLMs)

High-quality items are essential for producing reliable and valid assessments, offering valuable insights for decision-making processes. As the demand for items with strong psychometric properties increases for both summative and formative assessments, automatic item generation (AIG) has gained prominence. Research highlights the potential of large language models (LLMs) in the AIG process, noting the positive impact of generative AI tools like ChatGPT on educational assessments, recognized for their ability to generate various item types across different languages and subjects. This study fills a research gap by exploring how AI-generated items in secondary/high school physics aligned with educational taxonomy. It utilizes Bloom's taxonomy, a well-known framework for designing and categorizing assessment items across various cognitive levels, from low to high. It focuses on a preliminary assessment of LLMs ability to generate physics items that match the Bloom’s taxonomy application level. Two leading LLMs, ChatGPT (GPT-4) and Gemini, were chosen for their strong performance in creating high-quality educational content. The research utilized various prompts to generate items at different cognitive levels based on Bloom's taxonomy. These items were assessed using multiple criteria: clarity, accuracy, absence of misleading content, appropriate complexity, correct language use, alignment with the intended level of Bloom's taxonomy, solvability, and assurance of a single correct answer. The findings indicated that both ChatGPT and Gemini were skilled at generating physics assessment items, though their effectiveness varied based on the prompting methods used. Instructional prompts, particularly, resulted in excellent outputs from both models, producing items that were clear, precise, and consistently aligned with the Application level of Bloom's taxonomy.

Examining the impact of personalization and carefulness in AI-generated health advice: Trust, adoption, and insights in online healthcare consultations experiments

Artificial intelligence (AI) technologies, exemplified by health chatbots, are transforming the healthcare industry. Their widespread application has the potential to enhance decision-making efficiency, improve the quality of healthcare services, and reduce medical costs. While there is ongoing discussion about the opportunities and challenges brought by AI, more needs to be known about the public's attitude towards its use in the healthcare domain. Understanding public attitudes can help policymakers better grasp their needs and involve them in making decisions that benefit both technological development and social welfare. Therefore, this study presents evidence from two between-subjects experiments. This study aims to compare the public's adoption and trust levels in health advice provided by human vs. AI doctors and explore the potential effects of personalization and carefulness on the public's attitudes. Experimental designs adopt a trust-centered, cognitively and emotionally balanced perspective to study the public's intention to adopt AI. In Experiment 1, the experimental conditions involve the types of decision-makers providing online consultation advice, either AI or human doctors. In Experiment 2, the experimental conditions involve varying levels of perceived personalization and carefulness (high vs. low). A total of 734 participants took part in the study. They were randomly assigned to one of the intervention conditions and responded to manipulation checks after reading the materials. Using a seven-point Likert-type scale, participants rated their cognitive and emotional trust levels and intention to adopt the advice. Partial Least Squares Structural Equation Modeling (PLS-SEM) is conducted to estimate the proposed theoretical perspective. Qualitative interviews on both real-world and AI-generated treatment recommendations further enriched the understanding of public perceptions.The results show that AI-generated advice is generally slightly less trusted and adopted by the public. However, a noticeable inclination towards AI-generated advice emerges when AI demonstrates proficiency in understanding individuals' health conditions and providing empathetic consultations. Further analyses confirm the mediating influence of emotional trust between cognitive trust and adoption intention. These findings provide deeper insights into the process of adoption and trust formation. Moreover, they offer guidance to digital healthcare providers, empowering them with the knowledge to co-design AI implementation strategies that cater to the public's expectations.

More than law‐abiding: A multi‐staged consumer study on brand morality

AbstractToday's consumers expect brands to act morally to win their hearts and wallets. Yet, existing marketing literature provides little clarity on what this behavior entails and how it differs from acting ethically. This study aims to clarify these concepts and inspire further research. Our consumer‐centric research adopted a multi‐theory and multi‐method approach, coupling Moral Foundations with Morality as Cooperation theories, 12 in‐depth interviews and three surveys with 1229 respondents from two opposite national cultures. We present a Brand Morality scale involving three meaningful dimensions: brand care, brand compliance and brand competency. Brand care is more influential in establishing a moralistic image than the other dimensions. We also learn that while consumers from different national cultures may value the same set of BM dimensions on a cognitive level, they may interpret and react differently on a behavioral‐intent level. Our unique contributions include (i) presenting a 12‐item Brand Morality scale that is theoretically meaningful and practically applicable to brands, (ii) demonstrating the co‐utility of two under‐considered theories, (iii) clarifying the nuanced distinctions of brands acting morally versus ethically, and (iv) shedding light on consumers' perceptual definitions of BM may be consistent between nations, but their behavioral interpretations may vary depending on their local cultures.

Executive green cognition and corporate ESG performance

This paper examines how executive green cognition influences corporate ESG performance using data from Chinese listed companies. The results indicate that higher level of executive green cognition substantially enhance ESG performance. Specially, this paper finds that this positive impact is achieved through advancements in green innovation and improvements in the quality of environmental information disclosure. Additionally, heterogeneity analysis reveals that the benefits of executive green cognition on ESG performance are more significant in industries with lower competition and among non-state-owned enterprises. This paper introduces a novel perspective on enhancing ESG performance, offering valuable insights for promoting sustainable development within enterprises.

“3 + X D” structured report in radiology standardized resident training: Can it meet high-level teaching objectives?

PurposeTo evaluate the impact of the innovative “3 + X D” structured report (SR) designed based on Bloom’s taxonomy on the learning outcomes of radiology residents during standardized training. MethodsThis is a prospective study that recruited 120 radiology residents from our hospital between 2020 and 2022. Randomly selected 60 residents from the 2020 grade to constituted the control group, and randomly selected 60 residents from the 2021 grade to formed the experimental group. The former group was trained utilizing the Free-text Reports (FTR) template, while the latter group received training with the “3 + X D” structured reports (SR) template. The learning outcomes of both groups was evaluated utilizing both objective and subjective measures. Objective assessments encompassed examinations of theoretical knowledge, diagnostic skills, and total scores, aligning with the cognitive domains of remembering, understanding, applying, and analyzing as outlined by Bloom’s Taxonomy. Subjective assessments, on the other hand, comprised survey questionnaires administered to residents and feedback from clinical instructors, which correlated with the higher-order cognitive level of analyzing, evaluating, and creating within Bloom’s Taxonomy. ResultsOn 60 residents (mean age, 24.15 years ± 2.11[SD]; 25 male) from control group, and 60 residents (mean age, 24.58 years ± 1.88 [SD]; 27 male) from experimental group. Following the training, significant improvements were observed in the theoretical knowledge, diagnostic skills, and total scores for both groups (p < 0.001). Furthermore, the experimental group demonstrated significantly higher diagnostic skills and total scores compared to the control group (p < 0.001). However, no significant difference was observed in the theoretical knowledge exam between the two groups (p = 0.236). The questionnaire used for subjective assessments had good reliability (Cronbach α was 0.826) and acceptable validity (The KMO was 0.692). Additionally, the survey questionnaires indicated that the experimental group rated higher than the control group in terms of cultivating imaging thinking ability, diagnostic confidence, diagnostic speed, and the convenience of the templates (p < 0.001). Clinicians’ feedback scores for the experimental group markedly surpassed those for the control group (p < 0.05). ConclusionsUtilizing the “3 + X D” SR template grounded in Bloom’s taxonomy for training, the professional competency of radiology residents, particularly their diagnostic skills, saw a marked enhancement, successfully meeting the higher-level educational objectives. Consequently, the “3 + X D” SR template is highly recommended for the standardized training of radiology residents.

A cognitive modelling of translation

Abstract This paper attempts to usher in a cognitive linguistic theory into (cognitive) translation studies and offers a theoretical model of translation from the construal perspective. In this construal-based theory, translators are modelled as construers which are featured by subjectivity, and meaning decoding and encoding in translation are equated with construal which is manifested at two levels. At the cognitive level, translators construe the source text whereas at the linguistic level the construal established by the translators is packaged in the target language. Translation process involves translators’ construal operations such as perspective, selection, prominence and dynamicity, and imagination. Since construal is situated in context, it is impossible to recreate the construals of the source text author but optimal construal can be envisioned if the situated contexts for the source text author(s) as well as that for the target text are best accommodated.

Conservation of structural brain connectivity in people with multiple sclerosis

ABSTRACT Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. Structures affected in MS include the corpus callosum, connecting the hemispheres. Studies have shown that in mammalian brains, structural connectivity is organized according to a conservation principle, an inverse relationship between intra- and interhemispheric connectivity. The aim of this study was to replicate this conservation principle in subjects with MS and to explore how the disease interacts with it. A multicentric dataset has been analyzed including 513 people with MS and 208 healthy controls from seven different centers. Structural connectivity was quantified through various connectivity measures, and graph analysis was used to study the behavior of intra- and interhemispheric connectivity. The association between the intra- and the interhemispheric connectivity showed a similar strength for healthy controls (r = 0.38, p &amp;lt; 0.001) and people with MS (r = 0.35, p &amp;lt; 0.001). Intrahemispheric connectivity was associated with white matter fraction (r = 0.48, p &amp;lt; 0.0001), lesion volume (r = −0.44, p &amp;lt; 0.0001), and the Symbol Digit Modalities Test (r = 0.25, p &amp;lt; 0.0001). Results show that this conservation principle seems to hold for people with MS. These findings support the hypothesis that interhemispheric connectivity decreases at higher cognitive decline and disability levels, while intrahemispheric connectivity increases to maintain the balance.

Prevalence and risk factors of subjective cognitive decline in older adults in Baotou, China: a cross-sectional study.

Subjective cognitive decline (SCD) as a stage between healthy cognition and early neurocognitive disorders, has been proposed to be helpful in the diagnosis of prodromal neurocognitive disorders. To investigate the prevalence of SCD and the related risk factors on the prevalence. A cross-sectional study involving 1,120 elderly subjects residing in Baotou, China. From June 2021 to June 2023, the data were gathered by research assistants with training utilizing standardized questionnaires. The following factors were evaluated: subjective cognitive decline, physical and cognitive activity levels, past medical history, demographics, instrumental activities of daily living, and cognitive function. Risk factors of SCD were used chi-square tests and multivariate logistic regression analysis. The prevalence of SCD was 43.8%. Permanent residence, marital status, BMI, dietary habits, average sleep duration per night, smoking, diabetes, coronary heart disease, and visual impairment were significantly associated with SCD (p < 0 0.05). Multivariable logistic regression analysis showed obesity, vegetarian-based, smoking for a long time, diabetes and coronary heart disease, visual impairment, no spouse, and average sleep duration per night <6 h were independent risk factors for SCD. Based on the gender analysis, the difference in marital status, dietary habits, average sleep duration per night, smoking, drinking, and hypertension was statistically significant (p < 0.001). The prevalence of subjective cognitive decline was high among elder adults. We discovered significant differences in the prevalence or risk factors for SCD between men and women based on their sex. This study provides a more theoretical basis for the early prevention and screening of cognitive impairment diseases in the elderly population.

Forget About Memory: Disentangling the Amnestic Syndrome in Idiopathic Normal Pressure Hydrocephalus.

Idiopathic normal pressure hydrocephalus (iNPH) can present with both episodic amnestic syndrome and biomarkers of Alzheimer's disease (AD) pathology. To examine the associations between amnestic syndrome and cerebrospinal fluid (CSF) AD biomarkers in iNPH and the CSF tap test response in iNPH patients with amnestic syndrome. We used the Free and Cued Selective Reminding Test to divide iNPH into amnestic and non-amnestic patients. We compared their clinical, biological, and radiological characteristics and examined the reversibility of gait spatiotemporal parameters and neuropsychological performances after a CSF tap test. Univariate and multiple linear regression models examined the association between memory performance and clinical-biological characteristics. Sixty-two non-amnestic patients (mean age 77.0±7.0 years, 38.7% female) and thirty-eight amnestic patients (mean age 77.0±5.9 years, 36.8% female) presented similar levels of AD biomarkers and clinical-radiological profiles. Global cognition and education levels were lower in the amnestic iNPH group. We found no association between AD biomarkers and memory performances (total tau: β= -4.50; 95% CI [-11.96;2.96]; p = 0.236; amyloid-β (1-42): β= 8.60, 95% CI [-6.30;23.50]; p = 0.240). At baseline, amnestic iNPH patients performed worse on executive functions, attention, and gait speed but improved similarly to the non-amnestic iNPH patients after the tap test. In our clinical sample of iNPH patients, we confirm the lack of specificity of the amnestic profile for predicting AD pathology. Clinicians should not preclude amnestic iNPH patients from undergoing an invasive procedure of CSF derivation.

The Development of Liveworksheets-Assisted Discovery Learning Model Worksheets for Improving Student’s Critical Thinking Ability

Student Worksheets (LKS) are an interactive bridge between teachers and students, this is also related to measuring student learning outcomes. The use of worksheets affects the level of effectiveness in working on test questions. Stimulating students' cognitive critical thinking can be obtained, including from learning mathematics with the right approach method. One of the students' learning goals is to be innovative and creative in solving problems with solutions. The aim of this research is to develop a LKPD (Learner Worksheet) model of discovery learning assisted by a live worksheet to make it more effective and efficient and have the potential impact of growing students' cognitive level of critical thinking. The research method used is a design research model which is divided into two parts, namely preliminary (preliminary study and LKPD-Liveworksheet design) and formative evaluation including self-evaluation, prototyping (expert review, one-to-one, and small groups) research field tests as well revision. Research data was analyzed quantitatively and qualitatively. The research results show students' critical thinking abilities for Liveworksheet LKPD teaching materials with exponents and logarithms in the "Legal" and "Easy" categories according to experts and practitioners. The results of the research show that the LKPD developed is feasible, effective and influences students' critical thinking skills using the discovery learning model. The activities in this research have resulted in a product being developed in the form of a critical thinking worksheet using a discovery learning model assisted by a live worksheet which creates productive learning.

Effects of Combined Visual-Motor Response Training on Cognitive Function and Brain Plasticity Mechanisms in Various Populations: Protocol for a Single-Center, Open-Label, Controlled Clinical Trial.

Cognitive impairment is one of the major diseases facing the aging population. The progressive decline of cognitive function can lead to declining health or even the loss of life, work, and social ability. Exercise and behavioral stimulation can increase neurotransmitters in the brain and improve overall health and cognitive function. Reactivity training can mobilize neuromuscular function and induce changes in brain plasticity, which may effectively improve cognitive dysfunction and delay the occurrence and development of Alzheimer disease; however, the evidence supporting its effectiveness is still limited. This study aims to explore the effectiveness and reliability of visual-motor reaction training in improving cognitive function, thereby promoting the application of novel nonpharmacological therapies. This study is a single-center, open-label, controlled clinical trial. A total of 78 participants will be recruited for the study, including an equal number of athletes, ordinary healthy college students, and ordinary older adults in the community. Participants will receive 2 weeks of visual-motor response training. The primary outcome of this study is to assess differences in functional magnetic resonance imaging (fMRI) at 2 weeks. The secondary outcomes were the following: acousto-optic response time, Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Mini Mental State Examination (MMSE), Activity of Daily Living (ADL) Scale, Subjective Cognitive Decline Questionnaire-9 (SCD-Q9), a 10-word memory test, and safety. The study was approved by the Shanghai Clinical Research Ethics Committee on January 2, 2024 (SECCR/2023-162-01). As of September 11, 2024, we have completed the recruitment of all 3 groups of volunteers. We expect to complete data collection and analysis by February 2025. The purpose of this study is to compare improvements in brain perceptual motor functions and cognitive levels across different populations through response ability training and to explore the efficacy and safety of exercise-based nonpharmacological therapies in improving cognitive function. Other potential benefits include understanding the functional differences and perceptual characteristics of the brain's perceptual-motor system between athletes and the general population and exploring the adaptability of the brain in acquiring skills during competitive sports training. This could provide an evidence base for early sports talent development and broader youth development. Chinese Clinical Trial Registry ChiCTR2400079602; https://tinyurl.com/23fbbndw. DERR1-10.2196/56424.