Cognitive Impairment In Chinese Population Research Articles

Evaluation of a simple versus composite plasma biomarker model as screening strategy for the diagnosis of cognitive impairment in Chinese population

Evaluation of a simple versus composite plasma biomarker model as screening strategy for the diagnosis of cognitive impairment in Chinese population

Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults

Background Hypertension (HTN) is a very prevalent public health problem and as the population ages, cognitive impairment (CI) is also going to be a public health burden. However, the relationship between hypertension duration and cognitive function declination worldwide is still unknown. The aim of the study was to investigate the effects of HTN duration on CI in Chinese population. Methods At baseline, 1 386 HTN patients and 293 normotensive (NT) people were enrolled. The HTN patients were further divided into four subgroups (duration of HTN <6 years, 6–10 years, 11–20 years, and >20 years) according to the HTN duration and were screened for cognitive function with neuropsychological tests including mini-mental-stateexamination (MMSE) and clock-drawing-test (CDT) in comparison with the NT group. Results More HTN patients had CI (45.3%) than NT subjects (30.4%), and increased with HTN duration (P <0.000 1). Compared with the scores of MMSE and CDT in the NT group, the declines were higher in the HTN patients (P <0.000 1), and in the four HTN subgroups, both MMSE and CDT scores fall when the HTN duration increased (P <0.05). Furthermore, in the HTN population without CI, the trend in alteration of CI was relatively mild but still existed (P <0.05). Conclusion People with HTN are more likely to have CI and the possibility and aggravation increases the prolongation of HTN duration, both in amnesic and nonamnesic function.

A cross sectional study to examine the association between dietary patterns and cognitive impairment in older Chinese people in Hong Kong.

Dietary patterns can be identified using a priori and a posterior approaches. Few studies have related dietary patterns with cognitive impairment in Chinese population. This study examined the risk of cognitive impairment associated with dietary patterns identified by both approaches. Baseline data on 1,926 Chinese men and 1,744 Chinese women aged > 65 years participating in a cohort study examining the risk factors for osteoporosis in Hong Kong were analyzed. Dietary data were collected using a validated food frequency questionnaire. Adherence to a priori dietary patterns, namely the Mediterranean Diet Score (MDS) was assessed. Factor analysis (FA) identified three a posterior dietary patterns: "vegetables-fruits" pattern which was rich in vegetables, fruits, soy products and legumes, "snacks-drinks-milk products" pattern which was a mixture of healthy and unhealthy food groups including fast food, sweets and desserts, nuts, milk products and whole grains, and "meat-fish" pattern which included frequent intake of meat, fish and seafood. Cognitive function was assessed by the Community Screening Instrument for Dementia (CSI-D). Multivariate logistic regression examined the risk of cognitive impairment with adjustment for potential confounders. A total of 221 men and 656 women was classified as cognitive impaired. Neither the MDS nor the dietary patterns identified by FA were associated with risk of cognitive impairment in men. In women, higher "vegetables-fruits" pattern score was associated with reduced risk of cognitive impairment [Adjusted OR=0.73 (95% CI: 0.54-1.00) of the highest quartile of "vegetables-fruits" pattern score compared with the lowest quartile, ptrend=0.018]. Similar inverse trend was observed for "snacks-drinks-milk products" pattern score [Adjusted OR=0.65 (95% CI: 0.47-0.90) of the highest quartile of "snacks-drinks-milk products" pattern score compared with the lowest quartile, ptrend=0.003]. There was no association of "meat-fish" pattern or the MDS with risk of cognitive impairment in women. Higher "vegetables-fruits" and "snacks-drinks-milk products" pattern scores were associated with reduced risk of cognitive impairment in Chinese older women in Hong Kong.

Metabolic syndrome and cognitive impairment amongst elderly people in Chinese population: a cross‐sectional study

Recent studies have demonstrated an association between metabolic syndrome (MetS) and cognitive impairment in elderly individuals, however a relationship between MetS and cognitive impairment in the Chinese population has been less frequently reported. Therefore, the present study was designed to investigate the relationship between MetS and cognitive impairment in an elderly Chinese population. Of 3216 participants (1740 men and 1476 women), aged 60 years old and over were selected from three districts of Chongqing City. The presence of MetS was defined according to the updated Adult Treatment Panel III criteria, and cognitive function was measured by Mini-Mental State Examination and the Activity of Daily Living tests. Of the 3216 participants, 733 (22.8%) fulfilled the criteria for MetS, and 470 participants (14.6%; 236 men and 234 women) fulfilled the criteria for cognitive impairment. Amongst those with MetS, 183 participants (25%) also had cognitive impairment. In univariate analysis, MetS was significantly associated with cognitive impairment [odds ratio (OR) 2.55; 95% confidence interval (CI) 2.07-3.13]. Taking age, current smoking, hypertension and diabetes into account, multivariate logistic regression analysis showed that MetS was significantly associated with cognitive impairment (OR 2.31; 95% CI 1.91-2.95). MetS is associated with cognitive impairment amongst elderly people in the Chinese population.