Postoperative cognitive dysfunction (POCD) is a multifactorial adverse event most frequently in elderlypatients. POCD diagnosis usually demands a long neuropsychological battery. Mental Plus® video game was developed to evaluate cognitive function. It might also be a tool to use in future neuropsychological rehabilitation. The primary study objective was MentalPlus® reliability evaluation to assess cognition in healthy volunteers. METHODS: 163 volunteers were randomized to play MentalPlus® theme versions A and B with a week interval. The volunteer’s mental state was first evaluated applying Mini-Mental State Examination, and the study excluded volunteers with scores below 18 or 23 related to educational scores. Kappa index and McNemar test evaluated MentalPlus® applicability and reproducibility. RESULTS: The results disclosed the following characteristics: mean age of 36±16 years; 46 % male; School rank level mean of 5±2 years, the average benefits of 4.6± 3 Brazilian minimum wages. The Mini-Mental score was 28±3, for an expectation of more than 25±3. The MentalPlus® A and B theme versions results disclosed resulting kappa coefficients assessing reliability tests. General cognitive function presented a kappa coefficient of 0.7122 (p<0.005); selective attention and alternating attention revealed 0.4004 and 0.3998 (p<0.005); long-term memoryand inhibitory control had similar coefficients: 0.4103 and 0.4406 (p<0.005); and executive function, through constructing inhibitory control presented a kappa coefficient of 0.4406, There was a marked dispersion for visual perception, concerning to motion and resolution of objects: 0.2029 and0.2453 (p<0.005). The cognitive function scores in MentalPlus® were displayed as a mean and standard deviation and confidence interval of 95%, α=0.05. MentalPlus® theme versions A and B results were comparable with values utilized by researchers. CONCLUSION: MentalPlus® digital game displayed reliable evidence for cognitive function evaluation. It might be a future feasible instrument for POCD assessment and rehabilitation. Trial registration: www.clinicaltrials.gov Identifier: NCT02551952.