Cognitive Function In Older People Research Articles

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety

Objectives: Poor social connections may be associated with poor cognition in older people who are not experiencing mental health problems, and the trajectory of this association may be moderated by cognitive reserve. However, it is unclear whether this relationship is the same for older people with symptoms of depression and anxiety. This paper aims to explore social relationships and cognitive function in older people with depression and anxiety.Method: Baseline and two-year follow-up data were analysed from the Cognitive Function and Ageing Study–Wales (CFAS-Wales). We compared levels of social isolation, loneliness, social contact, cognitive function, and cognitive reserve at baseline amongst older people with and without depression or anxiety. Linear regression was used to assess the relationship between isolation and cognition at baseline and two-year follow-up in a subgroup of older people meeting pre-defined criteria for depression or anxiety. A moderation analysis tested for the moderating effect of cognitive reserve.Results: Older people with depression or anxiety perceived themselves as more isolated and lonely than those without depression or anxiety, despite having an equivalent level of social contact with friends and family. In people with depression or anxiety, social isolation was associated with poor cognitive function at baseline, but not with cognitive change at two-year follow-up. Cognitive reserve did not moderate this association.Conclusion: Social isolation was associated with poor cognitive function at baseline, but not two-year follow-up. This may be attributed to a reduction in mood-related symptoms at follow-up, linked to improved cognitive function.

Relationship between mild cognitive decline and oral motor functions in metropolitan community-dwelling older Japanese: The Takashimadaira study

BackgroundDiminished oral motor function is considered to be a factor influencing cognitive decline, but this association has not been clarified. The aim of the present study was to clarify the association between cognitive and oral motor function in older people with either from normal cognitive function or mild cognitive decline. MethodsA cross-sectional study was conducted across 1118 older people (445 men, 673 women) aged ≥70 years (mean age, 77.0 ± 4.7 years) who lived in a city of Tokyo Metropolis, Japan. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Older people who had an MMSE score of 23 points or lower were excluded. To investigate the relationship between cognitive and oral motor function, Pearson’s correlation, multiple linear regression, and path analysis were performed. ResultsPearson’s correlation revealed that, among the oral motor functions assessed, masticatory performance, occlusal force, and tongue pressure were correlated with MMSE score. Multiple linear regression showed that tongue pressure and oral diadochokinesis (ODK) were significantly associated with MMSE score. Path analysis revealed that decreases in tongue pressure and in ODK were directly associated with decreases in MMSE score. Decreases in tongue pressure were also indirectly associated with decreases in MMSE score via decreases in ODK. ConclusionsAmong the oral motor functions assessed, tongue pressure and ODK were associated with cognitive function in older people ranging from those with normal cognitive function to those with mild cognitive decline. Diminished tongue pressure and ODK might thus lead to cognitive decline.

Relationship between the FRAX index and physical and cognitive functioning in older people

Objective: To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people.Patients and methods: Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected.Results: A total of 375 patients were included (60% female) Patients with a low-risk FRAX for hip fractures had a higher Mini-mental (25, 95% CI = 24–27 vs. 22, 95% = 21 to 23, p = .0001), a higher Barthel index (88, 95% CI = 84–93 vs 72, 69 to 76, p = .0001) without differences in the Charlson index. Bivariate analysis showed an inverse association between FRAX and scales but logistic regression showed only female sex (OR 4.4, 95% CI = 2.6–7.6) and the non-dependent Barthel index (OR = 0.104, 95% CI = 0.014–0.792) remained significant and. Barthel index/Mini-mental constructed a significant model capable of predicting a risk of hip fracture of >3% measured by the FRAX index, with an area under the curve of 0.76 (95% CI = 0.7–0.81).Conclusions: The FRAX index is related to other markers of geriatric assessment and the association between these variables can predict a risk of hip fracture of >3% measured by the FRAX index.Key messagesGeriatric assessment indexes may be as important as the FRAX index, which is based on clinical risk factors, in predicting the fracture risk in older patient.

The Association Between Gait Speed and Cognitive Status in Community-Dwelling Older People: A Systematic Review and Meta-analysis.

Gait speed and cognitive performance tend to decline with age. A better understanding of the dynamics of the association between gait speed and cognitive status may identify preclinical markers and improve diagnostic assessments. The objective was to quantify the association between gait speed and cognitive status in later life. A systematic search was undertaken of relevant databases for original articles published prior to June 2017, measuring the association between gait speed and cognition cross-sectionally or longitudinally among the community-dwelling population. A meta-analysis pooled results of the mean difference between concurrent measures of gait speed in the normal cognition group compared to non-normal cognition groups. Thirty-six studies were selected, providing data from 29,520 participants. The majority of studies reported a significant association between slower gait speed and worse cognitive function in older people. Results of the meta-analysis of 27 studies showed that, compared to normal controls, clinically meaningful reductions in gait speed ranged from 0.11 m/s in those with cognitive impairment, to 0.20 m/s in those with mild dementia, and to 0.41 m/s in those with moderate dementia. The strength of evidence for an association between gait speed and cognition was demonstrated by the number and consistency of results, as well as quality of the studies. Identification of diagnostic markers of motor-cognitive risk has led to increasing interest in the effects of interventions for prevention of gait speed loss and cognitive decline in aging.

An active lifestyle and cognitive function: Evidence from China

Abstract How does an active lifestyle at baseline relate to cognitive functioning in later periods? To answer this question, we draw unique panel data from the China Health and Retirement Longitudinal Study (CHARLS). The analysis reveals that greater overall activity is associated with higher levels of memory and numeracy. The beneficial effects of being active vary across different activity types and aspects of cognition, but not so with respect to gender. Overall, these findings provide new empirical evidence on the relationship between an active lifestyle and cognitive functioning of older people in China.

A busy day has minimal effect on factors associated with falls in older people: An ecological randomised crossover trial

Fatigue is a common complaint in older people. Laboratory-induced muscle fatigue has been found to affect physical functions in older populations but these protocols are rigorous and are unlikely to accurately reflect daily activities. This study used an ecological approach to determine the effects of a busy day on self-reported fatigue and fall-related measures of physical and cognitive function in older people. Fifty community-dwelling adult volunteers, aged 60–88 (mean 73) years participated in this randomised crossover trial. Participants undertook assessments of balance, strength, gait, mobility, cognitive function and self-reported fatigue, before and after a planned rest day and a planned busy day (randomly allocated) at least one week apart. Participants wore an activity monitor on both the rest and busy days. On average, participants undertook twice as many steps and 2.5 times more minutes of activity on the busy, compared with the rest day. Participants had a significant increase in self-reported fatigue on the afternoon of the busy day and no change on the rest day. Repeated measures ANOVAs found no significant day (rest/busy) × time (am/pm) interaction effects, except for the timed up and go test of mobility, resulting from relatively improved mobility performance over the rest day, compared with the busy day. This study showed few effects of a busy day on physical and cognitive performance tests associated with falls in older people.

Relations Between Exercise Habit and Visual Attentional Ability in Older Adult Community Dwellers: Evidences From the Yakumo Study

Objective: The relation between mild everyday exercise and cognitive ability in healthy older people was examined using cohort study database. Methods: Individually calculated linear regression coefficients in digit cancelation task performances for 11 years age from 65 to 75 years were compared between mild exercise habit holders and non-holders. Results: Exercise habit holders showed significantly smaller age-related decline than non-holders, irrespective of task difficulty. Discussion: The results suggested that even mild exercise habit for long years possesses benefits on sustaining cognitive function in older people as well as the physical activities such as programmed in a sport gym. It also becomes clear that it is difficult for ordinary older adult to continue exercising habits for many years. Therefore, more substantial ways are required for local health officials to advertise the effectiveness of mild exercise habits and to devise the necessary work to become a habit.

Influence of Sequential vs. Simultaneous Dual-Task Exercise Training on Cognitive Function in Older Adults.

Emerging research indicates that exercise combined with cognitive training may improve cognitive function in older adults. Typically these programs have incorporated sequential training, where exercise and cognitive training are undertaken separately. However, simultaneous or dual-task training, where cognitive and/or motor training are performed simultaneously with exercise, may offer greater benefits. This review summary provides an overview of the effects of combined simultaneous vs. sequential training on cognitive function in older adults. Based on the available evidence, there are inconsistent findings with regard to the cognitive benefits of sequential training in comparison to cognitive or exercise training alone. In contrast, simultaneous training interventions, particularly multimodal exercise programs in combination with secondary tasks regulated by sensory cues, have significantly improved cognition in both healthy older and clinical populations. However, further research is needed to determine the optimal characteristics of a successful simultaneous training program for optimizing cognitive function in older people.

The Neighborhood Built Environment and Cognitive Function of Older Persons: Results from the Singapore Longitudinal Ageing Study

Background: We investigated the association of subjective (perceived) and objective (geographical information system [GIS]-based) measures of the neighborhood built environment (BE) attributes with cognitive function among older persons, and the mediating effect of transportation physical activity (TPA) and leisure time (physical, social and productive) activities (LTA). Method: A cross-sectional study of 402 residents aged 55 years and above in the Singapore Longitudinal Ageing Study. Perceived neighborhood BE attributes (residential density, street connectivity, land use mix - diversity, land use mix - access, infrastructure for walking or cycling, aesthetics, traffic safety, and crime safety) and objective GIS measures of walkability and accessibility were related to participants' cognitive global and domain-specific performance measured by Repeatable Battery for the Assessment of Neurocognitive Status (RBANS). Results: Controlling for age, sex, education, race, chronic medical illnesses, self-rated health, Geriatric Depression Scale depression score, POMA measures of balance and gait, and other BE attributes, the subjective measure of land use mix-diversity (standardized coefficient β = 0.161, p = 0.008) and GIS measure of walkability (β = 0.163, p = 0.002) were positively and significantly associated with RBANS global z-score, and immediate and delayed memory recall, visuospatial/ constructional ability and language, except attention. In hierarchical modeling, TPA and LTA attenuated the effect estimates, but the associations remained significant. Conclusion: BE features which increase opportunities and easy access to a diversity of destinations for services and facilities that promote physical, social and cognitively stimulating activities is associated with better cognitive functioning in older people.

Tackling the Toll of Hearing Loss on Executive Function

Tackling the Toll of Hearing Loss on Executive Function

The association between subjective memory complaint and objective cognitive function in older people with previous major depression.

The goal of this study is to investigate associations between subjective memory complaint and objective cognitive performance in older people with previous major depression–a high-risk sample for cognitive impairment and later dementia. A cross-sectional study was carried out in people aged 60 or over with previous major depression but not fulfilling current major depression criteria according to DSM-IV-TR. People with dementia or Mini-Mental State Examination score less than 17 were excluded. Subjective memory complaint was defined on the basis of a score ≧4 on the subscale of Geriatric Mental State schedule, a maximum score of 8. Older people aged equal or over 60 without any psychiatric diagnosis were enrolled as healthy controls. Cognitive function was evaluated using a series of cognitive tests assessing verbal memory, attention/speed, visuospatial function, verbal fluency, and cognitive flexibility in all participants. One hundred and thirteen older people with previous major depression and forty-six healthy controls were enrolled. Subjective memory complaint was present in more than half of the participants with depression history (55.8%). Among those with major depression history, subjective memory complaint was associated with lower total immediate recall and delayed verbal recall scores after adjustment. The associations between subjective memory complaint and worse memory performance were stronger in participants with lower depressive symptoms (Hamilton Depression Rating Scale score<7). The results suggest subjective memory complaint may be a valid appraisal of memory performance in older people with previous major depression and consideration should be given to more proactive assessment and follow-up in these clinical samples.

Blood pressure variability and cognitive decline in older people: a 5-year longitudinal study.

Cognitive impairment is common in later life. Identifying potential modifiable risk factors for cognitive decline may ameliorate the burden of disease. Cross-sectional studies show an association between blood pressure (BP) variability and impaired cognitive function in patients with hypertension and/or dementia. However, research examining the association between BP variability and cognitive function in the general older population is scarce. In this study, we examined the association between BP variability and cognitive function over 5-year follow-up in an unselected community-dwelling cohort. Ambulatory BP monitoring was performed in 353 community-dwelling people aged at least 65 years. Cognitive assessment, using the Mini Mental State Examination (MMSE) and Cambridge Cognitive Examination (CAMCOG), was performed at baseline and at 5-year follow-up. BP variability was calculated using the coefficient of variation. Cognitive change over 5 years was defined as baseline score minus follow-up score. Increased daytime systolic variability was associated with poorer performance on the CAMCOG total score and subscores. Daytime diastolic variability was associated with poorer performance on total CAMCOG, CAMCOG executive score, and MMSE. These findings were independent of demographic and cardiovascular risk factors. Daytime systolic variability was also independently associated with greater decline in total CAMCOG and MMSE scores over 5-year follow-up. Increased BP variability is associated with poorer cognitive function in older people and may represent a novel modifiable risk factor for cognitive decline.

Auditory speed tasks as potential candidates for the study of cognitive ageing

ABSTRACTSpeed of information processing is an important cognitive ability. It facilitates the efficient operation of higher order cognitive functions, such as reasoning, and is implicated in various models of cognitive decline. The present study considers the potential benefits of expanding the measurement of processing speed to include the auditory modality. It examines the reliability and factorial structure of a variety of auditory and visual speed tasks in a sample of N = 138 older adults aged between 51 and 82 years. Our findings demonstrate that auditory measures can be used to assess processing speed as indexed by existing widely used tests of this ability. Moreover, the inclusion of auditory tasks significantly increases the relationship between processing speed and general cognitive ability. This novel research provides strong evidence of the suitability of auditory speed tasks for the study of cognitive function in older people, and demonstrates the importance of expanding cognitive measurement to include alternate modalities.

A Bespoke Kinect Stepping Exergame for Improving Physical and Cognitive Function in Older People: A Pilot Study.

Systematic review evidence has shown that step training reduces the number of falls in older people by half. This study investigated the feasibility and effectiveness of a bespoke Kinect stepping exergame in an unsupervised home-based setting. An uncontrolled pilot trial was conducted in 12 community-dwelling older adults (mean age 79.3 ± 8.7 years, 10 females). The stepping game comprised rapid stepping, attention, and response inhibition. Participants were recommended to exercise unsupervised at home for a minimum of three 20-minute sessions per week over the 12-week study period. The outcome measures were choice stepping reaction time (CSRT) (main outcome measure), standing balance, gait speed, five-time sit-to-stand (STS), timed up and go (TUG) performance, and neuropsychological function (attention: letter-digit and executive function:Stroop tests) assessed at baseline, 4 weeks, 8 weeks, and trial end (12 weeks). Ten participants (83%) completed the trial and reassessments. A median 8.2 20-minute sessions were completed and no adverse events were reported. Across the trial period, participants showed significant improvements in CSRT (11%), TUG (13%), gait speed (29%), standing balance (7%), and STS (24%) performance (all P < 0.05). There were also nonsignificant, but meaningful, improvements for the letter-digit (13%) and Stroop tests (15%). This study found that a bespoke Kinect step training program was safe and feasible for older people to undertake unsupervised at home and led to improvements in stepping, standing balance, gait speed, and mobility. The home-based step training program could therefore be included in exercise programs designed to prevent falls.

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.

The aim of our scoping review was to summarize the state of the art regarding micronutrients in order to identify which of them might effectively improve health status in the areas typically impaired in older people: bone, skeletal muscle, and cognitive function. Scoping review. The Italian Study Group on Healthy Aging by Nutraceuticals and Dietary Supplements (HANDS) performed this scoping review, based on the following steps: doing a list of micronutrients related with musculoskeletal or cognitive functions, included in dietary supplements and nutraceuticals commercialized in Italy; planning a research on PubMed, according to an evidence-based approach, in order to the most relevant positive study for each micronutrient into each of the three areas involved (bone, skeletal muscle and cognitive function); identifying the micronutrients effective in maintaining or achieving an adequate health status in older people, specifying the effective and safe daily doses, according to the selected studies. In literature we found 12 relevant positive studies (1 international society guidelines/recommendations, 1 systematic review, 7 randomized controlled trials, and 3 prospective cohort studies). We showed that only 16 micronutrients resulted to have appropriate scientific evidences in terms of improving musculoskeletal health and/or cognitive function in older people: beta-alanine, calcium, creatine, fluorides, leucine, magnesium, omega-3 fatty acids, potassium, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K2, and zinc. This scoping review showed that selected micronutrients in adequate doses might have an ancillary role in musculoskeletal health and cognitive functions in older people.

Study Protocol on Hormonal Mediation of Exercise on Cognition, Stress and Immunity (PRO-HMECSI): Effects of Different Exercise Programmes in Institutionalized Elders.

Physical activity (PA) in elders has been shown to have positive effects on a plethora of chronic diseases and to improve immunity, mental health, and cognition. Chronic stress has also been shown to have immuno-suppressive effects and to accelerate immunosenescence. Exercise could be a significant factor in ameliorating the deleterious effects of chronic stress, but variables such as the type, intensity, and frequency of exercise that should be performed in order to effectively reduce the stress burden need to be defined clearly. PRO-HMECSI will allow us to investigate which hormonal and immunological parameters are able to mediate the effects of exercise on mucosal immunity, psychological/biological stress, and cognitive functioning in older people. Phase I consists of an observational cross-sectional study that compares elders groups (n = 223, >65 years) by functional fitness levels aiming to identify biomarkers involved in maintaining immune and mental health. Neuroendocrine and immune biomarkers of stress, psychological well-being related to mental health, neurocognitive function, functional fitness, and daily PA will be evaluated. Phase II consists of a 28-week intervention in elders with mild cognitive impairment (MCI) profile (n = 149, >65 years, divided in three groups of exercise and one control group), aiming to investigate whether the positive effect of three different types of chair-based exercise programs on physical and psychological health is mediated by an optimal endocrine environment. Primary outcomes are measures of cognitive function and global health. Secondary outcomes include the evaluation the other dimensions such as immune function, psychological health, and depression. Few studies addressed the effects of different types of exercise interventions in older population samples with MCI. We will also be able to determine which type of exercise is more effective in the immune and hormonal function of this population.

Dietary Nitrate Reduces Blood Pressure And Improves Walking Economy And Cognitive Function In Older People

Nitric oxide (NO), produced by the enzyme nitric oxide synthase (NOS), is a signalling molecule that regulates vascular tone, neurotransmission and mitochondrial function. NOS activity declines in older age contributing to increased morbidity and reduced exercise capacity. Increasing the intake of dietary inorganic nitrate (NO3-) might elevate NO bioavailability via an alternative NO3- -nitrite (NO2-) -NO reduction pathway and therefore compensate for NOS dysfunction. PURPOSE: To determine whether dietary supplementation with nitrate-rich (BR), compared to nitrate-depleted (PL), beetroot juice in healthy older adults will reduce blood pressure (BP), lower pulmonary O2 uptake (VO2) during walking and improve cognitive function. METHODS: 30 participants (age 73±3 yr, BMI 25±3 kg/m2) underwent 10-day supplementation periods with BR (~0.6 g NO3-/d) and PL (negligible NO3-) separated by a 10-day wash-out in a double-blind randomised cross-over design. The speed and accuracy of components of cognitive function were assessed via a computer-based Rapid Visual Information Processing (RVIP) test. Pulmonary VO2 was measured during three 6-min bouts of walking at 80% of gas exchange threshold. RESULTS: Plasma [NO3-] and [NO2-] were greater after BR (361 ± 55 μM and 969 ± 687 nM) than PL (34 ± 26 μM and 162 ± 96 nM) (both P<0.05). Systolic BP was lower after BR (124 ± 14 mmHg) than PL (129 ± 15 mmHg; P<0.05) but diastolic BP was not different between BR (69 ± 7 mmHg) and PL (70 ± 8 mmHg; P>0.05). Steady state VO2 during treadmill walking was lower after BR (861 ± 195 mL/min) than PL (892 ± 196 mL/min; P<0.05). The number of correct responses (BR: 20 ± 5, PL: 19 ± 6; P>0.05) and reaction time (BR: 726 ± 200, PL: 715 ± 146 ms; P>0.05) during the RVIP test were not different, but the number of errors made was lower in BR (6 ± 8) than PL (10 ± 11; P<0.05). CONCLUSIONS: The 4% reduction in systolic BP following BR may reduce the incidence of adverse cardiovascular events in older age. The lower O2 cost of walking and the lower number of errors made in the RVIP task in BR compared to PL suggests positive effects on cellular metabolism and cognitive function following NO3- supplementation. Collectively, these findings may have important implications for enhancing quality of life in older age.

Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people.

Physical exercise, especially aerobic training, improves physical performance and cognitive function of older people. Furthermore, it has been speculated that age-associated deteriorations in physical performance and cognitive function could be counteracted through exposures to passive intermittent normobaric hypoxia (IH). Thus, the present investigation aimed at investigating the effect of passive IH combined with subsequent aerobic training on hematological parameters and aerobic physical performance (V˙O2max) as well as peripheral levels of the neurotrophin brain-derived neurotrophic factor (BDNF) and cognitive function. Randomized controlled trial in a repeated measure design. 34 older participants were randomly assigned to an intervention group (IG) or control group (CG). While IG was supplied with passive IH for 90min, CG breathed ambient air. Subsequently, both groups underwent 30min of aerobic training three times per week for four consecutive weeks. Aerobic physical performance and cognitive function was tested with spiroergometry and the Stroop test. Blood samples were taken to measure hematological parameters and the peripheral serum BDNF-level. We found increases in the values of hematological parameters, the time to exhaustion in the load test and an augmented and sustainable improvement in cognitive function within the IG of the older people only. However, in both groups, the V˙O2max and serum BDNF-level did not increase. Based on these results, hypoxic training seems to be beneficial to enhance hematological parameters, physical performance and cognitive function in older people. The current hypoxic-dose was not able to enhance the serum BDNF-level or V˙O2max.

Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial.

Background:Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia.Objectives:To investigate effects of exercise on cognitive function in people with dementia.Method:The Umeå Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umeå, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean Mini-Mental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity. Blinded assessors measured global cognitive function using the MMSE and the Alzheimer’s disease Assessment Scale – Cognitive subscale (ADAS-Cog), and executive function using Verbal fluency (VF) at baseline and 4 months (directly after intervention completion), and MMSE and VF at 7 months.Results:Linear mixed models showed no between-group effects in mean difference from baseline (95% confidence intervals, CI) at 4 months in MMSE (–0.27; 95% CI –1.4 to 0.87, p = 0.644), ADAS-Cog (–1.04, 95% CI –4 to 1.92, p = 0.491), or VF (–0.53, 95% CI –1.42 to 0.35, p = 0.241) or at 7 months in MMSE (–1.15, 95% CI –2.32 to 0.03, p = 0.056) or VF (–0.18, 95% CI –1.09 to 0.74, p = 0.707).Conclusion:A 4-month, high-intensity functional exercise program had no superior effects on global cognition or executive function in people with dementia living in nursing homes when compared with an attention control activity.

Cognitive Impairment Risk Factors in Elders

Purpose: This study was done to provide ways to prevent cognitive deterioration by identifying the risk factors for cognitive impairment. Methods: Data were collected by questionnaires from elders using Senior Centers. Participants were 210 people, 105 with suspicious dementia and 105 with normal cognitive function. Measures were MMSE-DS, ADL, IADL, social relationships and SGDS-K. Data were analyzed using descriptive statistics, x2-test, t-test and logistic regression analysis with SPSS/WIN 22.0 program. Results: In logistic regression analysis, the probability of having suspicious dementia was 2.6 times (95% CI 1.02~6.76) higher for elderly women than elderly men. Elders age 80 or over had 2.6 times (95% CI 1.26~5.38) more chance of exposure to suspicious dementia than elders age of 65~79. Also, non-educated elders had 4.2 times (95% CI 2.05~8.62) more probability than elders with elementary school graduation or above, elders and older persons with mild depression had 3.1 times (95% CI 1.09~8.62) more probability of suspicious dementia than elders with major depression. Conclusion: To maintain and promote the cognitive function of older people, it is necessary to consider these cognitive impairment risk factors and develop nursing intervention programs to prevent cognitive deterioration.