Cognitive Function In Elderly People Research Articles

Improved Cognitive Function and Emotional Condition Measured Using Electroencephalography in the Elderly during Horticultural Activities

The aim of this study was to compare the physiological and psychological effects in the elderly during horticultural and nonhorticultural activities as leisure activities. A total of 58 participants aged 65 or older (29 men and 29 women; average age, 74.0 ± 4.7) whose cognitive function was within the normal range were included in this study. Participants performed four horticultural and four nonhorticultural activities for 2 min, respectively. The study had a cross-over experimental design. Electroencephalography was performed during all the activities. Subjective evaluation of emotions was performed using the Profile of Mood States immediately after each activity. The collected statistical data were analyzed using Duncan’s test as a post-analysis of variance test to verify the differences in the results of electroencephalography and the Profile of Mood States according to the different activities. In the results of the electroencephalography, the relative beta, gamma, low-beta, and ratio of sensorimotor rhythm to theta indices indicate that the degree of brain activity in the prefrontal lobe was high during activities such as washing leaves, transplanting plants, and reading news. The results of the Profile of Mood States showed that during activities such as arranging flowers, transplanting, and washing leaves, the total mood disorder score was lowered, indicating a positive effect on the mood of the participants. This study shows that activities such as washing leaves, transplanting, and reading news have a positive effect on the cognitive function of elderly people by increasing brain activity.

An fMRI Investigation into the Effects of Ketogenic Medium-Chain Triglycerides on Cognitive Function in Elderly Adults: A Pilot Study.

Evidence suggests that oral intake of medium-chain triglycerides (MCTs), which promote the production of ketone bodies, may improve cognitive functions in elderly people; however, the underlying brain mechanisms remain elusive. We tested the hypothesis that cognitive improvement accompanies physiological changes in the brain and reflects the use of ketone bodies as an extra energy source. To this end, by using functional magnetic resonance imaging, cerebral blood oxygenation level-dependent (BOLD) signals were measured while 20 healthy elderly subjects (14 females and 6 males; mean age: 65.7 ± 3.9 years) were engaged in executive function tasks (N-back and Go-Nogo) after ingesting a single MCT meal (Ketonformula®) or placebo meal in a randomized, double-blind placebo-controlled design (UMIN000031539). Morphological characteristics of the brain were also examined in relation to the effects of an MCT meal. The MCT meal improved N-back task performance, and this was prominent in subjects who had reduced grey matter volume in the dorsolateral prefrontal cortex (DLPFC), a region known to promote executive functions. When the participants were dichotomized into high/low level groups of global cognitive function at baseline, the high group showed improved N-back task performance, while the low group showed improved Go-Nogo task performance. This was accompanied by decreased BOLD signals in the DLPFC, indicative of the consumption of ketone bodies as an extra energy source.

Music Recommendation System Driven by Physiological Evaluation Appearing in Fingertip Skin Temperature

In recent years, music therapy has been performed with the aim at recovering the cognitive function of elderly people. In the previously reported system, it was necessary to input the subjective evaluation of the user to determine the next recommended song. In this study, variations in fingertip skin temperature were used as input instead of subjective evaluation, focusing on evaluation of emotion expressed as physiological response through variations in fingertip skin temperature. Our system can be used with no support for users.

THE EFFECT OF VIRTUAL REALITY ON COGNITIVE FUNCTIONS IN LADIES WITH DEMENTIA: LITERATURE REVIEW

Introduction: The decline in cognitive function that occurs in the elderly with dementia will have an impact on decreasing daily physical and social activities in the elderly resulting in decreased quality of life for the elderly. One of the interventions that can be used to maintain cognitive function in the elderly is by using virtual reality. Purpose: The purpose of this study is to explain the effect of virtual reality on cognitive function in elderly people with dementia based on empirical studies in the last five years. Method: the process of searching for journals or articles using a database indexed by Scopus, ProQuest, and Science Direct using adequate keywords. The framework used for the review was PICOS and the inclusion criteria used were English-language journals with issues from 2015 to 2020. Data analysis and tabulation were carried out in articles or journals. Title, abstract, full text, and methodology are assessed to determine the eligibility of the article or journal. Results: 758's articles were identified, ten articles fit the research criteria. Virtual reality affects cognitive function where it can improve memory, attention, executive function and can increase the overall scale of the MoCA. The advantage over the use of virtual reality for the elderly with dementia is that it not only improves cognitive but also improves motor coordination, reduces behavioral and psychological symptoms, and can be used to detect cognitive impairments early. Conclusion: In carrying out cognitive rehabilitation programs in the elderly can use technology-based interventions by using virtual reality.

Influence of manganese exposure on cognitive function, plasma APP and Aβ levels in older men

BackgroundElevated manganese (Mn) exposure impairs cognition in adults and children, but the association between Mn and cognitive function in elderly people is unclear. Previous studies have linked Mn neurotoxicity in AD to Aβ-dependent mechanisms. However, the association between Mn and plasma APP and Aβ in the general elderly population remains unknown. This study aimed to investigate the association between Mn exposure and cognitive function, plasma APP and plasma Aβ in older adults. MethodsCognitive abilities in 375 men aged 60 and older in Guangxi, China were assessed using the Mini-Mental State Examination (MMSE) and cognitive impairment were identified using education-stratified cut-off points of MMSE scores. Urinary Mn levels and plasma APP, and Aβ levels were measured using ICP-MS and ELISA, respectively. ResultsA total of 109 (29.07 %) older men were identified as having cognitive impairment. The median urinary Mn level was 0.22 μg/g creatinine. Urinary Mn levels were negatively correlated with MMSE scores (β = −1.35, 95 % CI: −2.65 to −0.06; p = 0.041). In addition, higher concentrations of urinary manganese were associated with a greater risk of cognitive impairment (OR = 2.03, 95 % CI: 1.14–3.59; comparing the highest and lowest manganese; p = 0.025). Moreover, plasma APP levels were inversely associated with urinary Mn levels (r = −0.123, p = 0.020), and positively associated with MMSE scores (r = 0.158, p = 0.002). Surprisingly, no correlations were observed between plasma Aβ42, Aβ40, Aβ40/Aβ42, or Aβ42/Aβ40 and urinary Mn levels and MMSE scores. ConclusionThese results suggested that Mn exposure is negatively associated with older men’s cognition and plasma APP levels, but not plasma Aβ levels.

DEMENTIA IN DR. SOETOMO GENERAL HOSPITAL SURABAYA: A SYNTHETIC REVIEW OF ITS CHARACTERISTICS

Background: Dementia is a clinical syndrome characterized by progressive loss of cognitive function in elderly people interferes the ability to function independently. The number of elderly patients increased so fast in worldwide. The prevalence of dementia rapidly increases due to increasing of population. Aging demographic transition is proceeding rapidly especially in China, India, and Latin America, where dementia is rapidly becoming the major public health problem. Demographic data of elderly patients of dementia in Indonesia is still a little. Dementia’s research data in Indonesia were only obtained from Bali and Yogyakarta, while data from Surabaya were not obtained. Our research data is taken from Dr. General Hospital Soetomo Surabaya, East Java, Indonesia. This study is important for dementia epidemiological data and baseline data for further treatment of dementia patients in Surabaya. Objective: The purpose of this study to determine the characteristics profile of elderly patients with dementia in Dr. Soetomo General Hospital Surabaya, East Java, Indonesia. Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2017 to December 2017 based on inclusion and exclusion criterias that have been set. The data was taken from the patient's medical record which had been written and examined by neurologists from the neurology department in the neurobehaviour sub-department of Dr. Soetomo Surabaya. Results: The majority of dementia patients are men (51,7%); the age group which is most at risk for dementia is between age of 75-79 years; most of the patients are jobless; more than half of patients are high school graduates; and Vascular Dementia (VaD) is the type of dementia that most people suferred Conclusion: This characteristic’s data of dementia can be used for providing information about dementia to make public health care provides a better facillities and treatment for elderly patients to prevent dementia burden.

Effects of serum homocysteine, depression and instrumental daily living ability on cognitive function in elderly people at high altitudes

AbstractBackgroundTo explore the level Homocysteine (Hcy), depressive state and daily living ability on the decline of cognition ability in elderly under hypoxic environment.MethodBetween June 2017 and June 2019, 288 participants of elderly (mean aged 67.13 years) Han subjects living in Xining City (altitude 2,260 meters) of Qinghai Province were divided into three groups: 125 Mild cognitive impairment (MCI), 20 Alzheimer’s disease (AD), 83 control. Serum HCY level was determined by BECKMAN COULTER biochemical analyzer. The cognition ability were used by Mini‐mental State Examination (MMSE), Geriatric Depression Scale (GDS), Auditory Verbal Learning Test (AVLT),Digit Span Test)DST),Activities Daily Living (BADL), Instrumental Activities of Daily Living (IADL). Fund project: National Key R&D Program of China (No : 2018YFC1315201).Result1. There was no significant difference in age, gender, educational level among the three groups. 2. Compared with controland MCI groups, Hcy of AD group was significantly increased (p<0.05). GDS and IADL scores of AD group was significantly higher than MCI and control groups (p<0.05,p<0.01). 3. Compared with control group, BADL score of AD group was significantly increased (p<0.01), while there was no significant difference the BADL score between control and MCI group (p> 0.05). 4. The scores of DST, AVLT and MMSE in the forward and reverse direction, delayed memory, attention, calculation and working memory and visuospatial ability of HHcy group were significantly lower than those of normal Hcy group (p<0.01, p<0.05, p<0.05). 5. MMSE score was negatively correlated with Hcy, IADL and GDS (r=‐0.324, ‐0.228,‐0.191;p<0.01,p<0.05). Logistic analysis showed that HCY was the risk factor of cognitive dysfunction (OR=1.005, 95% CI: 1.005‐1.109, p<0.05).ConclusionThe decline of cognition ability in the elderly at high altitude is correlated with Hcy, IADL and GDS. HHcy is the major risk factor for cognitive dysfunction. Combined MMSE, GDS and IADL scale scores provide objective basis for the warning, prevention and control of early cognitive dysfunction in the elderly under hypoxic environment.

The Importance of Physical Activity in the Interaction of Motor and Cognitive Functions in Elderly People

Background. It is predicted that in 2060, the number of elderly people in Lithuania (62 and over years of age) will be 31.2% (Tamutienė & Naujanienė, 2013). The maintenance of stable posture requires particular attention because it gets more difficult to sustain it while doing multiple moves at the same time when you are getting older (Woo, Davids, Liukkonen, Chow, & Jaakkola, 2017). The aim of the study was to determine the importance of physical activity for the interplay of motor and cognitive functions in elderly people.
 Methods. Evaluation of static equilibrium by posturographic method, evaluation of cognitive functions, statistical analysis.
 Results. The results of the physically active and inactive research subjects were statistically significant (p = .043) in memory task with the eyes closed and in a simple position. A statistically significant difference in the sway velocity (Vsc) between the physical activity groups with eyes closed in simple position was also observed (p = .044). Double task with eyes closed resulted in worse balance performance.
 Conclusions. 1. Physical activity did not affect the motor function of the elderly. There were no differences between the physically active and inactive subjects in the assessed behavioral indices. 2. Physical activity did not affect the cognitive functions of the elderly. All elderly subjects were equally mistaken in their cognitive memory task. 3. The motor functions of the physically active elderly are controlled statistically significantly better when performing additional cognitive tasks than those of the physically inactive ones.
 Keywords: balance, elderly, physical activity.

Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.

Matcha Green Tea Powder contains a variety of active ingredients beneficial to health, such as tea catechins, lutein and vitamin K. It is also known that these ingredients confer benefits upon cognitive functions of elderly people. Therefore, we aimed to investigate the relationship between a daily supplementation of Matcha and the change in cognitive functions of community-dwelling elderly people. A randomized, double-blind, placebo-controlled 12-week trial was performed. Sixty-one participants were recruited and randomly assigned to receive test drink containing 3 g powder from fresh Matcha or placebo powder per day. Changes in cognitive function were assessed utilizing a psychometric test battery. Daily food intake was assessed by a Brief-type Self-administered Diet History Questionnaire (BDHQ). In the gender-specific analysis, a significant cognitive enhancement was observed in the Montreal Cognitive Assessment (MoCA) score in the active group of women. In dietary analysis, we found a significant inverse correlation between consumption of vitamin K in daily diet, excluding test drinks, and change in MoCA. The present study suggests that daily supplementation of Matcha Green Tea Powder has protective effects against cognitive decline in community-dwelling elderly women.

The effect of whole body vibration by sonic waves on mood, the autonomic nervous system, and brain function in elderly

The purpose of this study was to clarify the effect of sonic wave vibration (SWV) on mood, the autonomic-nervous system, brain function and cognitive function in elderly people. We randomly assigned 24 late-stage elderly people (M 88.0±5.0 yrs) into a SWV group and a control group. The SWV group conducted 10 minutes of SWV per day, 5 days a week for 8 consecutive weeks. For evaluation purposes, we analyzed the moods with TDMS, heart rate variability (HRV), resting energy expenditure (REE), and brain activation during the Stroop test using near-infrared spectroscopy (NIRS). The stability level and pleasure level of mood increased significantly immediately after SWV. Simultaneously, the levels of the parasympathetic nervous system index of HRV significantly increased while the levels of the sympathetic nervous system index significantly decreased. REE also significantly increased. These results suggest that SWV has a relaxation effect as well as increasing the energy expenditure for elderly people. After intervention, Stroop B's execution time significantly decreased suggesting an improvement in the processing speed. The NIRS revealed that SWV may therefore activate the frontal lobe function. These results suggest that SWV may have a positive effect on mood, the autonomic nervous system, cognitive function and brain functions, and thus such treatment may be useful for elderly people.

Acupuncture for mild cognitive impairment in elderly people: Systematic review and meta-analyses.

Background:Acupuncture has an unique role in preventing and managing mild cognitive impairment (MCI) in nonpharmaceutical therapies because of its small wound, mild pain, and high security for many years. However, there is no systematic review evaluating safety and efficacy of acupuncture for MCI in elderly people. Therefore, this study will provide a protocol to explore the effectiveness and safety of acupuncture for MCI in the elderly.Methods:Retrieval from 8 electronic databases was conducted to determine eligible trials published until May, 2019. Homogeneity qualified studies were included for data were extracted such as study country location, demographic characteristics, and measure outcomes, and were analyzed by a random effect model and sensitivity analyses to identify heterogeneity. Review Manager (Revman Version 5.3) software will be used for data synthesis, sensitivity analysis, meta regression, subgroup analysis, and risk of bias assessment. A funnel plot will be developed to evaluate reporting bias.Results:A total of 15 randomized control trials involving 1051 subjects were included. The results were as follows: Compared with the control group, the clinical efficacy rates of acupuncture was better, odds ratio = 2.52, 95% confidence interval (CI) (1.86, 3.42), P < .00001, mini-mental state examination scores (mean difference [MD] = 1.53, 95% CI [1.04, 2.01], P < .00001), Montreal cognitive assessment scores (MD = 2.05, 95% CI [1.17, 1.92], P < .00001), activity of daily living scale (MD = 1.71, 95% CI [–1.38, 4.79], P > .05), and clock drawing task scores (MD = 1.91, 95% CI [1.74, 2.08], P < .00001).Conclusion:This study shows that acupuncture is beneficial for improving aspects of cognitive function in elderly people with MCI, which suggests that acupuncture may be an effective alternative and complementary approach to existing therapies for elderly people. More rigorous experimental studies and longer follow-up studies should be conducted in the future.

Hypoglycemia and the risk of cognitive impairment and dementia in elderly and senile patients with type 2 diabetes

Research results show that poor glycemic control and recurrent episodes of severe hypoglycaemia are associated with a decrease in cognitive function in elderly people with type 2 diabetes mellitus (T2DM). On the other hand, patients with diabetes mellitus associated with cognitive impairment/dementia are most at risk of developing hypoglycaemic conditions. It is obvious that the relationship between hypoglycaemia and dementia is very complex and has a mutually aggravating nature.&#x0D; Studies also show that individuals of older age groups with diabetes and cognitive impairment have a high risk of developing hypoglycaemic conditions, such as unwanted side effects from glucose-lowering therapy. In this case, of particular interest is the question that is being actively studied at the present time, which is concerning the effect of different groups of glucose-lowering antidiabetic drugs on the cognitive status and the rate of cognitive decline in diabetic patients with cognitive impairment.&#x0D; In this review, we attempted to summarise, systematise, and present data available in the literature concerning the effect of hypoglycaemia on the risk of cognitive impairment and dementia in elderly and senile patients with type-2 diabetes, as well as the degree of participation in this process of of various groups of sugar-lowering antidiabetic drugs.

The Study of the Correlation between Cognition Function and Quality of Sleep in the Elderly

Background/Objectives: Sleep function affects human health,Recently, studies on various variables affecting mental health management and cognitive function of elderly people are being actively conducted due to the increase of elderly population. The purpose of this study was to investigate the correlation between cognitive function and quality of sleep in the elderly.Method/Statistical Analysis: The participation was 33 normal elders over 65-year-old. Cognition function was evaluated with the Montreal Cognitive Assessment (MoCA), and quality of sleep was evaluated with sleep Scale A. The data were then analyzed for frequency and correlation by using statistical software (SPSS 21.0).Findings: The average age of the study subjects was 82.4 years. The average MoCA score was 17.1±3.8 and sleep scale A score was 29.6±8.9. The results of MoCA and sleep scale A showed a positive correlation(r = .417, p<.05).Improvements/Applications: The results of the study show that the lower the quality of sleep in the elderly, the lower the cognitive function. The results of this study will discuss whether sleep quality can be used to predict mental health in older adults.

Effect of Obesity on Cognitive Functions in Elderly People

Aim: We aimed to evaluate effect of obesity on cognitive functions in 65 years and older patients. Methods: This study was conducted in the Recep Tayyip Erdogan University Family Medicine outpatient clinic between November 2018 and January 2019. 65 years and older 83 voluntary patients were included in our study. All participants evaluated by a survey for their socio-demographic characteristics, Standardized Mini Mental Examination Test and Rey Auditory and Verbal Learning Test. Statistical comparison was made between patients’ body mass indexes and their test scores. Results: Mini Mental Test total score was statistically higher in men. Besides that, working patients had higher Mini Mental Test total score compared to retired patients and housewives. As participants’ waist circumference and body mass index increase, their Mini Mental Test language scores were decreasing. Conclusions: We found that as body mass index increases, Mini Mental Test language scores were significantly decreasing. In literature there are studies that suggesting obesity is related to decline in cognitive functions, but there are also studies that suggesting obesity has protective effect for cognitive decline. More comprehensive prospective studies are required for clearer results. Keywords: geriatrics, obesity, cognitive dysfunction

The Effect of Eucalyptol on Nursing Home Residents

Eucalyptol is one of the most popular volatile components. It is used in many essential oils for relieving sinus and lung congestion caused by a variety of conditions. This pilot study sought to analyze clinical evidence for the effect of the scent of eucalyptol on the cognitive function of elderly people. Seventy nursing-home residents with cognitive impairment were recruited. Three one-week experiments were performed: eucalyptol scent was diffused in bedrooms with a diffuser only at wake-up time in the first experiment, and at wake-up time and bedtime in the second and third experiments. Results showed that although an improvement was not seen when using Mini Mental State Examination (MMSE) and Cohen-Mansfild Agitation Inventory (CMAI) measures, Dementia Behavior Disturbance Scale (DBD) scores improved significantly, even though no subject reported perceiving the scent. The significant improvements of the behaviour were found not only among the subjects whose room had a diffuser but also among the subjects who were exposed to an unperceivable level of eucalyptol drifted in the living room.

Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.

ObjectiveCardiovascular diseases are representative risk factors for the onset of cognitive decline. The purpose of this study was to confirm the relationship between diastolic blood pressure and cognitive function in elderly people in Korea. MethodsData from subjects who were enrolled in the prospective Korean Longitudinal Study on Cognitive Aging and Dementia were used in this study. Data from 701 subjects whose diastolic blood pressure range did not change (≤79 mm Hg or ≥80 mm Hg) over 2 years were analyzed. To analyze the differences in cognitive function between the groups at the 2-year follow-up, an analysis of covariance was performed with covariates, which were significantly different between the two groups, and the baseline cognitive function. ResultsSignificant differences were observed between the two groups, and the mean scores on the constructional praxis (η2=0.010) and word list recall tests (η2=0.018) in the diastolic blood pressure ≥80 mm Hg group were higher than those in the diastolic blood pressure ≤79 mm Hg group at the 2-year follow-up. ConclusionThese results indicate that maintaining a DBP below 79 mm Hg presents a greater risk of cognitive decline in Korean elderly people.

Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice.

Neuroinflammation accompanies or even precedes the development of cognitive changes in many brain pathologies, including Alzheimer’s disease. Therefore, dampening inflammatory reactions within the brain is a promising strategy for supporting cognitive functions in elderly people and for preventing the development of neurodegenerative disorders. Nicotinic acetylcholine receptors containing α7 subunits (α7 nAChRs) are involved in regulating cell survival, inflammation, and memory. The aim of our study was to evaluate the efficiency of α7-specific therapy at different stages of inflammation and to compare the effects of orthosteric agonist PNU282987 and type 2 positive allosteric modulator (PAM) PNU120596 in mice after a single injection of lipopolysaccharide (LPS). The data presented demonstrate that PNU282987 protected mice from LPS-induced impairment of episodic memory by decreasing IL-6 levels in the blood, stabilizing the brain mitochondria and up-regulating the brain α7-, α3-, and α4-containing nAChRs. Such treatment was efficient when given simultaneously with LPS or a week after LPS injection and was not efficient if LPS had been injected 2 months before. PNU120596 also decreased IL-6, stabilized mitochondria and up-regulated the brain nAChRs. However, its memory-improving effect was transient and disappeared after the end of the injection cycle. Moreover, cessation of PNU120596 treatment resulted in a sharp increase in IL-1β and IL-6 levels in the blood. It is concluded that activating α7 nAChRs protects the mouse brain from the pathogenic effect of LPS in the early stages of inflammation but is not efficient when irreversible changes have already occurred. The use of a PAM does not improve the effect of the agonist, possibly potentiates the effect of endogenous agonists, and results in undesirable effects after treatment cessation.

Estimating cognitive function in elderly people using information from outdoor walking

Estimating cognitive function in elderly people using information from outdoor walking

Supplementation of Catfish (Clarias gariepinus) Oil Enriched with Omega-3 Soft Capsule Improves Oxidative Stress and Cognitive Function in Elderly.

Elderly is defined as an age group that is susceptible to various diseases. The aging process in the elderly is associated with an increase in oxidative stress activity which can lead to various health problems which are a major cause of high mortality and morbidity. This study aimed to analyze the effect of supplementation of catfish (Clarias gariepinus) oil enriched with omega-3 soft capsule on oxidative stress and cognitive function of elderly people. The design of this study was a single blind randomized control trial. A total of 29 elderly subjects were chosen following these inclusion criteria: aged >60 y; had dyslipidemia; and signed the informed consent. Subject were divided into three groups i.e. SO (soybean oil), CFO (commercial fish oil), and CO with omega-3 (catfish oil enriched with omega-3). The intervention was 1,000 mg oil/d administered for 90 d. The results showed that different supplementation groups had significant effects on oxidative stress and cognitive function (p<0.05). Supplementation of catfish oil enriched with omega-3 was able to significantly decreased malondialdehyde (MDA) level (p<0.05) and significantly increased mini mental state examination (MMSE) score (p<0.05). Overall, CO with omega-3 supplementation for 90 d was able to improve oxidative stress and cognitive function of the elderly better than other groups.

The Efficacy of Cognitive Training for Elderly Chinese Individuals with Mild Cognitive Impairment.

The age of the population is shifting toward the elderly range, which may lead to an increased risk of mild cognitive impairment (MCI). The aims of this study are to evaluate the cognitive function in elderly people using the Montreal Cognitive Assessment (MoCA), to identify the relationship between cognitive function and different characteristics, and to evaluate the efficacy of the intervention after six months of cognitive training. In this study, we included 2886 subjects aged ≧60 years in the baseline survey, and 140 subjects with MCI who participated in the baseline survey were randomly divided into an intervention group (N = 70) and a control group (N = 70). The control group was not provided any intervention measures, and the intervention group was administered cognitive training. The education level, monthly income, sleep time, exercise time, reading times, and time spent engaging in community activities and performing housework were positively correlated with MoCA scores, but age was negatively correlated with MoCA scores. The total MoCA score of the intervention group increased from 19.77 ± 2.24 points to 21.09 ± 2.20 points after six months of cognitive training, but the score of the control group decreased from 20.41 ± 2.10 points to 19.17 ± 2.57 points. The two-way repeated-measures ANOVA revealed a very significant effect of the interaction between time and cognitive training on the total MoCA score. Seventeen participants in the intervention group improved to normal levels, and no participants progressed to dementia after six months of cognitive training. Thus, the efficacy of the intervention was statistically significant. Our study concludes that older age is associated with a cognitive decline. Factors that are more likely to protect against cognitive decline included a higher education level and monthly income, sufficient sleep time, regular physical exercise and reading, frequently engaging in community activities, and continuing to perform housework. Moreover, the cognitive training intervention is effective and may help to decrease the deterioration of cognitive function in patients with MCI, and the interaction between intervention time and cognitive training significantly improves cognitive function.