Adjustment of cerebral blood flow (CBF) to neuronal activity (neurovascular coupling) is essential for normal neuronal function. Oxidative stress occurring with aging impairs neurovascular coupling contributing to the risk of vascular cognitive impairment. Resveratrol is a polyphenolic compound with anti-aging protective effects. We investigated the capacity of resveratrol to improve neurovascular coupling in aging. In aged (24 mo) mice NO-mediated CBF responses to whisker stimulation and to the endothelium-dependent dilator acethylcholine (ACh) were impaired compared to young (3 mo) mice. Treatment of aged mice with resveratrol rescued neurovascular coupling and ACh-induced responses associated with down-regulation of cortical NADPH oxidase expression and decreased levels of oxidative/nitrative stress (3-nitrotyrosine, 8-isoprostanes). Resveratrol attenuated age-related increases in ROS production in cultured cerebromicrovascular endothelial cells (DCF fluorescence). In conclusion, treatment with resveratrol rescues cortical neurovascular coupling in aged mice likely by restoring cerebromicrovascular endothelial function via down-regulation of NADPH-oxidase derived ROS production. Cerebromicrovascular effects of resveratrol may contribute to its protective effects on cognitive function in aging.