The stress-induced release of cortisol has been linked to detrimental health outcomes. Therefore, strategies to attenuate cortisol stress responses are of interest for prevention and treatment of stress-related symptoms and problems. Previous studies have found protective effects of cognitive-behavioral stress management training--which focuses on the modification of stress-inducing cognitions--on cortisol stress responses; however, the effects of resource-oriented interventions on cortisol stress responses are unknown. The longitudinal effects of resource-oriented stress management training (Zurich resource model training) on cortisol stress responses and cognitive appraisal of a standardized psychosocial stress test were evaluated in 54 healthy male participants assigned randomly to treatment and control groups. The Trier Social Stress Test (TSST; C. Kirschbaum, Wust, & Strasburger, 1992) was administered to all participants 3 months after the treatment group underwent stress management training. Saliva cortisol samples were taken before, during, and after the TSST, and cognitive stress appraisal was assessed before the test. The treatment group had significantly attenuated cortisol responses and stress appraisals in comparison to the control group. The endocrine differences were mediated by differences in cognitive appraisals. These results indicate that resource-oriented stress management training effectively reduces endocrine stress responses to stress in healthy adults.