Cognitive Capacity Research Articles

Yoga-Nidra as a mental health booster: A narrative review

Mental health disorders are treated with all the available advanced health techniques. The pioneers of Indian philosophy, sages, saints, and yogis, through their experiences and rational explanations, expressed the importance of yoga, and their treatment effects. Yoga-Nidra (YN), one of a particular forms of yoga, is described as a simple and precise way of dealing with mental disorders. The use of YN as an intervention has been reported to reduce anxiety, anger, depression, post-traumatic stress disorder (PTSD), and other different kinds of psycho-physiological abnormalities. In addition to the role of Yoga-Nidra as an intervention tool, it also brings relaxation to the mind and brain, mental catharsis, a positive attitude, self-improvement, and personality refinement. At the same time, YN contributes to boost concentration, memory, and other cognitive capacities, including attention, and thoughts.Because of its important therapeutic contribution to psychological well-being and mental health, it is currently used as a therapy and medical intervention. Yoga-Nidra and other yogic practices will play an important role in treating mental, physical, and psychological problems and improving cognitive abilities, and will help to connect with oneself.

29 Regulate to Remember: Cognitive Reappraisal Ability Impacts Prospective Memory Performance

Objective:Emotion regulation is generally thought of as the process of overriding one's initial emotional response to personally relevant events. One frequently investigated type of emotion regulation is cognitive reappraisal, which describes one's ability to cognitively alter the meaning of an event. Cognitive reappraisal is associated with better cognitive, social, and health outcomes compared to other emotion regulation strategies. The cognitive building blocks of cognitive reappraisal are related to executive cognitive control processes, which broadly describe one's ability to engage in non-automatic and goal-oriented behaviors. Crucially, executive control processes are also relevant in demanding cognitive tasks such as prospective memory since, similarly to cognitive reappraisal, they involve effortful and purpose driven efforts. However, cognitive reappraisal has thus far not been investigated regarding prospective memory performance despite findings that suggest that emotionally evocative stimuli improve prospective memory performance. The present study investigated whether cognitive reappraisal state and trait measures as well as other types of emotion regulation strategies are associated with prospective memory accuracy of negatively valenced prospective memory targets.Participants and Methods:A total of 45 participants (69% women; M = 22.62 years, SD = 5.69 years) took part in this cross-sectional study. Cognitive reappraisal and prospective memory tasks were administered on the computer. A total of 106 pictures were shown in the prospective memory task, including 12 prospective memory hits. A 2-back paradigm was used as the effortful ongoing task. Dependent measures included accuracy of and reaction times to negative prospective memory hits. A total of 45 pictures were shown in the cognitive reappraisal task. Participants were asked to decrease their negative emotions when looking at previously normed negatively valenced pictures versus merely looking at them (Lang et al., 2001). Dependent measures in the cognitive reappraisal task included success of downregulating negative emotion after the DECREASE versus LOOK instruction. A mood manipulation check and a questionnaire asking about participants' reappraisal strategies was conducted. Trait based measures of emotion regulation included the Emotion Regulation Questionnaire and the Dysfunction of Emotion Regulation Scale.Results:Participants endorsed significantly higher negative mood after looking at negative versus neutral pictures, t(48) = 22.77, p , .05). Ratings further indicated that participants were able to significantly decrease how negative they felt when reappraising versus looking at negative pictures, t(44) = 12.82, p , .05. Regarding the relationship between prospective memory accuracy of negatively valanced prospective memory targets and cognitive reappraisal ability, no significant bivariate correlation was found (p > .05). However, a significant bivariate correlation was found between reaction times to negatively valenced prospective memory targets and cognitive reappraisal ability (rs = -.32, p = .03). No significant relationship was observed between prospective memory accuracy of or reaction times to negatively valenced prospective memory targets and trait based measures of emotion regulation (all ps > .05).Conclusions:Hypotheses were partly supported. Higher state-based cognitive reappraisal abilities may be associated with lower cognitive costs when asked to remember negatively evocative pictures and/or higher overall cognitive capacity. The importance of assessing emotion regulation when utilizing emotionally evocative stimuli and their clinical significant is discussed.

9 Predictive Ability of the Performance Assessment of Self-Care Skills (PASS) in a Sample of Predominantly Low-Income, Community Dwelling, African American Older Adults

Objective:Mild decline in independent functioning is a core diagnostic criterion for Mild Cognitive Impairment. Performance-based assessments have been considered the gold standard to identify subtle deficits in functioning. Existing assessments were largely designed using demographically homogenous samples (white, highly educated, middle class) and often assume tasks are performed similarly across populations. The current study aimed to validate the utility of the Performance Assessment of Self-Care Skills (PASS) in determining cognitive status in a sample of predominantly African American, low-income older adults.Participants and Methods:Cognition and functional capacity were measured in n=245 older participants (aged 50+ years) who were recruited from a larger community study located in Pittsburgh, PA. Cognitive status was defined by a mean split on the Modified Mini Mental Status Examination (3MS) score (84/100). Participants above the cutoff were classified as unlikely cognitive impairment (UCI) and those below classified as potential cognitive impairment (PCI). Functional capacity was assessed using the number of cues provided on three PASS subtasks: shopping, medication management, and critical information retrieval (higher score = worse functioning). Self-reported cognitive and functional decline was assessed via the Everyday Cognition (ECog) questionnaire (higher score = greater decline). Generalized linear models compared performance scores between groups adjusting for literacy (WRAT3), age, and education. Receiver operating characteristic curve (ROC) analyses were run for select functional performance scores to assess their predictive ability in discriminating between PCI and UCI.Results:Compared to the UCI group (N = 179), the PCI group (N = 66) was older (68 vs. 65 years, p = 0.05), less educated (11 years vs. 12 years, p < 0.01), had lower WRAT3 z-scores (0.19 vs. -0.55, p < .01), and required more cues on the shopping (4.33 vs. 8.54, p < 0.01) and medication management PASS subtasks (2.74 vs. 6.56, p < .01). Both groups reported elevated levels of subjective cognitive complaints on the ECog (1.46 vs. 1.56, p = .09) and performed similarly on the critical information retrieval PASS subtask (0.25 vs 0.54, p = .06). When discerning between UCI and PCI groups, the PASS Shopping subtask had an optimal cut-off score of 4, sensitivity of 0.86, specificity of 0.47, positive predictive value (PPV) of 0.37, and area under the curve (AUC) of 0.71. PASS Medication Management had an optimal cut-off score of 3, sensitivity of 0.77, specificity of 0.56, PPV of 0.39, and AUC of 0.74.Conclusions:Subjective functional decline and performance on the critical information retrieval subtask were not associated with cognitive groups. PASS shopping and medication management had moderately high AUCs, suggesting they can reliably distinguish between groups. However, both tasks also exhibited low PPVs, low levels of specificity, and high levels of sensitivity, making them strong “rule-out” tests but poor “rule-in” tests in this sample. Because accurate assessment of functioning is useful for MCI and critical to dementia diagnosis, it is imperative we understand how these tasks function across different populations. Future work should 1) validate measures of functional ability across different populations and 2) develop population-appropriate assessments for use in clinical and research settings.

47 Social Cognition and Moral Decision Making in Korsakoff's Syndrome

Objective:Korsakoff's syndrome (KS) is a neuropsychiatric disorder, caused by vitamin B1 insufficiency. KS is characterized by severe declarative amnesia. Often, also executive disorders are present. Emotion recognition and theory of mind are gold-standard measures of social cognition. Moral decision making is often assessed by means of moral dilemmas. Surprisingly social cognition and moral decision making has received hardly any attention in research on KS, although the severity of behavioural problems in KS suggest possible problems in both domains. The aim of this study was therefore to broadly assess social cognition and moral decision-making capacities in patients with KS.Participants and Methods:20 KS patients and 20 age-, education-, and gender-matched healthy controls were assessed on standardized tests for social cognition, namely the mini-Social Cognition and Emotional Assessment battery (mini-SEA), and a specialized version of the Sally-Anne Test. Moral decision making was assessed by means of the Moral Behaviour Inventory (MBI) for everyday moral dilemmas, and ten cartoons of abstract moral dilemmas. For moral decision making, “yes” and “no” responses were scored, together with a scoring for moral reasoning according to the Kohlberg stages of moral maturity.Results:KS patients have large impairments in both cognitive and affective aspects of social cognition. Their ability to recognize emotions, take the perspective of others, and understand socially awkward situations is vastly compromised. While KS patients were able to replicate the Sally Anne storyline, their task performance was on chance level. Regarding moral decision making, there was a tendency to more frequently carry out the moral dilemma. Moral maturity, as indexed by means of their reasoning behind the decision was of a lower level. Of interest, moral immaturity could find its origin already before the onset of the KS diagnosis, as suggested by elevated premorbid levels of delinquent behavior.Conclusions:Both social cognition and moral decision making are compromised in KS patients. Specifically social cognitive disorders are the direct result of KS, and are likely to strongly relate to social and neuropsychiatric issues in KS. Moral decision making was more likely to be already of a lower level of maturity, based on a strong relationship between premorbid delinquency and moral immaturity in KS patients. This study highlights the importance to properly index social cognition in neuropsychological assessments for individuals with a possible KS diagnosis

Knowledge forms and gendered moralities in policies of infant care in Brazil

Inspired by the anthropology of social policy, this article explores the labyrinth of knowledge forms, politics and morality through which a certain programme for early childhood development (ECD) has unfolded in Brazil. By tracking the materiality of ideas – the actors who defend them, the experiments that back them, and the institutional vectors that assure them legitimacy – I weave together variegated threads from neuroscientists, BBC documentaries and Brazilian politicians to moralised motherhoods, criminal brains and, finally, a surprising appraisal on the diminished cognitive capacity of a whole population. Nurtured in the critical analyses of intensive parenting and correlated discussions on ‘chaotic concepts’, I hope to seize on the Brazilian experience to incorporate a new variable into the cost-benefit equation often used to favour ECD – that of the moral fall-out concerning visions of gender, family and class.

Transplanting old organs promotes senescence in young recipients

In clinical organ transplantation, donor and recipient ages may differ substantially. Old donor organs accumulate senescent cells that have the capacity to induce senescence in naïve cells. We hypothesized that the engraftment of old organs may induce senescence in younger recipients, promoting age-related pathologies. When performing isogeneic cardiac transplants between age-mismatched C57BL/6 old donor (18 months) mice and young and middle-aged C57BL/6 (3- or 12- month-old) recipients , we observed augmented frequencies of senescent cells in draining lymph nodes, adipose tissue, livers, and hindlimb muscles 30 days after transplantation. These observations went along with compromised physical performance and impaired spatial learning and memory abilities. Systemic levels of the senescence-associated secretory phenotype factors, including mitochondrial DNA (mt-DNA), were elevated in recipients. Of mechanistic relevance, injections of mt-DNA phenocopied effects of age-mismatched organ transplantation on accelerating aging. Single treatment of old donor animals with senolytics prior to transplantation attenuated mt-DNA release and improved physical capacities in young recipients. Collectively, we show that transplanting older organs induces senescence in transplant recipients, resulting in compromised physical and cognitive capacities. Depleting senescent cells with senolytics, in turn, represents a promising approach to improve outcomes of older organs.

Individuals with developmental disabilities make their own stylistic contributions to text written with physical facilitation

IntroductionFor individuals with developmental disabilities (DD) such as autism, Down syndrome, or cerebral palsy, learning to express with language is a two-fold challenge because atypical cognitive capacity is compounded by sensorimotor coordination deficits. One approach to assisting linguistic expression in these individuals is to physically support them, for example, by touching their torso or arm as they type. The neurophysiological mechanism of such motor assistance for linguistic expression is not known, but recently it has been proposed that light touch may reduce the cognitive load associated with the sensorimotor coordination of typing, thereby releasing shared cognitive resources to the task of generating content. Historically, there has been significant controversy over the extent to which the facilitator and not the user authors texts written with touch assistance. User groups and a few researchers have argued that the user can express their thoughts through such techniques, but the prevailing view among researchers is that these texts are entirely the by-products of the facilitators' ideomotor cueing of users' movements. If the user is not a source of the produced text, the only linguistic style detectable in the text should be the facilitator's.MethodsHere, we use quantitative linguistic analysis to investigate whether DD users typing text with touch assistance exhibit their own stylistic signatures alongside those of their facilitators. In Study 1, we investigate whether the stylometric fingerprints of a set of users are detectable when they are all assisted by the same facilitator. In Study 2, we examine whether the users' stylometric characteristics are retained even when they are assisted by multiple facilitators.ResultsAcross both studies, the results show that the users' stylistic signature is detectable alongside that of facilitators. This suggests that the texts generated by DD users withphysical assistance should be viewed as coauthored rather than wholly authored by facilitators via ideomotor processes.DiscussionThe users' stylometric presence in these texts suggests that touch-assistance may serve as a developmental scaffold and should be re-appraised as a teaching aid even where unassisted linguistic expression is an unlikely end goal.

Applying artificial intelligence to determination of legal age of majority from radiographic data

Forensic odontologists use biological patterns to estimate chronological age for the judicial system. The age of majority is a legally significant period with a limited set of reliable oral landmarks. Currently, experts rely on the questionable development of third molars to assess whether litigants can be prosecuted as legal adults. Identification of new and novel patterns may illuminate features more dependably indicative of chronological age, which have, until now, remained unseen. Unfortunately, biased perceptions and limited cognitive capacity compromise the ability of researchers to notice new patterns. The present study demonstrates how artificial intelligence can break through identification barriers and generate new estimation modalities. A convolutional neural network was trained with 4003 panoramic-radiographs to sort subjects into 'under-18' and 'over-18' age categories. The resultant architecture identified legal adults with a high predictive accuracy equally balanced between precision, specificity and recall. Moving forward, AI-based methods could improve courtroom efficiency, stand as automated assessment methods and contribute to our understanding of biological ageing.

“Where lies the grail? AI, common sense, and human practical intelligence”

AbstractThe creation of machines with intelligence comparable to human beings—so-called "human-level” and “general” intelligence—is often regarded as the Holy Grail of Artificial Intelligence (AI) research. However, many prominent discussions of AI lean heavily on the notion of human-level intelligence to frame AI research, but then rely on conceptions of human cognitive capacities, including “common sense,” that are sketchy, one-sided, philosophically loaded, and highly contestable. Our goal in this essay is to bring into view some underappreciated features of the practical intelligence involved in ordinary human agency. These features of practical intelligence are implicit in the structure of our first-person experience of embodied and situated agency, deliberation, and human interaction. We argue that spelling out these features and their implications reveals a fundamental distinction between two forms of intelligence in action, or what we call “efficient task-completion” versus “intelligent engagement in activity.” This distinction helps us to see what is missing from some widely accepted ways of thinking about human-level intelligence in AI, and how human common sense is actually tied, conceptually, to the ideal of practical wisdom, or good (normative) judgment about how to act and live well. Finally, our analysis, if sound, also has implications for the important ethical question of what it means to have AI systems that are aligned with human values, or the so-called “value alignment” problem for artificial intelligence.

Study on the Reconstruction of the Concept of Criminal Sanctions in the Juvenile Justice System

Objective: This research examines the reconstruction of the concept of criminal sanctions in the juvenile justice system with a focus on rehabilitative approaches and protecting children's rights. Theoretical framework: International scientific reports, articles, and publications served as the basis for the theoretical contents. Additionally, actual materials from criminal cases were used to explain the issue under investigation in a more thorough and objective manner. Method: Used to analyze the experiences, views, perceptions, and social context involved in the research subjects. This research involved interviews with legal practitioners, judges, social workers, and individuals related to juvenile justice cases, as well as collecting data from legal documents such as court decisions and related legislation. The data collection process begins with the selection of key informants who have knowledge and experience in the juvenile justice system. Results and conclusion: The research findings indicate that traditional criminal sanctions are less effective in changing children's behavior and may exacerbate their situation. Therefore, the recommendation is to change the concept of criminal sanctions in the juvenile justice system to prioritize rehabilitative, educational and social reintegration approaches. The need to respect children's rights, the principles of restorative justice, and community protection are also stressed. Comparison with the adult justice system shows that the juvenile justice system is more focused on rehabilitation and education. In conclusion, the concept of criminal sanctions in the juvenile justice system has a major impact on the effectiveness of the rehabilitation of juvenile offenders and the protection of their rights, with the importance of prioritizing rehabilitative approaches and children's rights in the application of criminal sanctions. Originality/value: The juvenile justice system is an important aspect of the legal system which aims to protect, educate and rehabilitate children involved in criminal acts. The concept of criminal sanctions in the context of juvenile justice has a very crucial role in achieving these goals. Children as a vulnerable group require a different legal approach to adults, considering their limitations in terms of experience, cognitive capacity, and physical and emotional development. In dealing with the complexity of juvenile crimes, it is necessary to adopt an approach that is more educational and supportive of children's development, rather than merely punishing.

Guinea baboons are strategic cooperators.

Humans are strategic cooperators; we make decisions on the basis of costs and benefits to maintain high levels of cooperation, and this is thought to have played a key role in human evolution. In comparison, monkeys and apes might lack the cognitive capacities necessary to develop flexible forms of cooperation. We show that Guinea baboons (Papio papio) can use direct reciprocity and partner choice to develop and maintain high levels of cooperation in a prosocial choice task. Our findings demonstrate that monkeys have the cognitive capacities to adjust their level of cooperation strategically using a combination of partner choice and partner control strategies. Such capacities were likely present in our common ancestor and would have provided the foundations for the evolution of typically human forms of cooperation.

Risky and non-risky financial investments and cognition

Much policy attention has been placed on encouraging saving behaviours to avoid financial deprivation at older adulthood. However, optimising financial investments is highly dependent on cognitive capacity, which can be deteriorated by the natural ageing process. This paper explores the relationship between age-related cognitive deterioration with risky and non-risky financial investments. The data analysed comes from eight waves (2002 to 2019) of the English Longitudinal Study of Ageing (ELSA) which, for a nationally representative sample, contains information about cognitive ability and their ownership of financial investments over time. Cognition emerges as one of the strongest predictors of the type and number of financial products that individuals hold. Specifically, the results show a positive relation of cognitive level with risky and non-risky financial investments. Even alongside other important factors – such as education, labour status, age, and household wealth – the explanatory power of cognition is found to be significant at the 0.1% significance level. The results are robust when accounting for unobservables and when using a genetic measure of cognition as main explanatory variable. More importantly, cognitive deterioration is only significantly associated with risky financial investments. That means, individuals reduce their risky financial investments when they start suffering old age related cognitive deterioration, while they do not change their holdings in non-risky ones in a significant manner. There are also no significant differences in the reactions to stock-market fluctuations due to cognitive level. In other words, individuals react to stock market fluctuations changing their financial holdings, but those reactions do not differ due to their cognitive level.

Transmission Versus Truth, Imitation Versus Innovation: What Children Can Do That Large Language and Language-and-Vision Models Cannot (Yet)

Much discussion about large language models and language-and-vision models has focused on whether these models are intelligent agents. We present an alternative perspective. First, we argue that these artificial intelligence (AI) models are cultural technologies that enhance cultural transmission and are efficient and powerful imitation engines. Second, we explore what AI models can tell us about imitation and innovation by testing whether they can be used to discover new tools and novel causal structures and contrasting their responses with those of human children. Our work serves as a first step in determining which particular representations and competences, as well as which kinds of knowledge or skill, can be derived from particular learning techniques and data. In particular, we explore which kinds of cognitive capacities can be enabled by statistical analysis of large-scale linguistic data. Critically, our findings suggest that machines may need more than large-scale language and image data to allow the kinds of innovation that a small child can produce.

The fear of loss of autonomy as lever for vaccination of the elderly: a qualitative study

Abstract The COVID-19 pandemic has highlighted the challenges of vaccination and the infectious risks among the elderly. According to available data, vaccination rates for recommended vaccines in this population are insufficient in France. The aim is to identify the levers and obstacles to vaccination among seniors, and then to shed light on the possible arguments that could lead to a commitment to new vaccination behaviours. A qualitative survey based on 14 semi-structured interviews was conducted with people aged 65 and over, living at home in the Auvergne Rhône-Alpes region (France) from March to May 2022. The interviews were recorded, transcribed in their entirety and then subjected to a thematic content analysis by two independent persons. The participants declared themselves to be in good health and to be concerned about maintaining their health by keeping their physical and cognitive capacities and their autonomy. To this end, they mentioned carrying out preventive behaviours, such as regular physical activity and a balanced diet. However, vaccination, which is associated with infectious disease prevention, was not mentioned as a factor in the prevention of good ageing during the interviews. Participants’ experiences of the polio epidemic and the COVID-19 pandemic highlighted older people's fears of infections. While infections are not a source of fear, their after-effects, more specifically, physical and cognitive alterations leading to a loss of autonomy, are a source of apprehension. These elements could be a good lever to bring hesitant elderly people to think about their own vaccination. In the light of these elements, given the protection against cardiovascular events provided by vaccinations for the elderly (influenza, shingles, pneumococcus), this argument could be the starting point for a prevention campaign aimed at the elderly. This avenue will be tested more precisely and with a larger number of subjects in a quantitative study based on a questionnaire. Key messages • the protection against cardiovascular events provided by vaccinations for the elderly (influenza, shingles, pneumococcus) seems to be argument could be change vaccination behavior. • Older people are not afraid of infections but of the consequences they can have, such as loss of autonomy.

P076 Comparing Four Different Simulated Shiftwork Schedules on Higher order Cognitive Function

Abstract Introduction Changes in cognitive performance during shiftwork due to fatigue and circadian misalignment are well-documented. However experimental evaluations of shiftwork schedules are often limited to basic tasks such as vigilance and attention. The current study evaluated several higher order cognitive functions such as memory and task switching during four simulated shiftwork schedules. Methods N=27 completed a 10-day laboratory shiftwork simulation. They were randomly assigned to one of four shiftwork conditions: Condition A, 4h-on/4h-off/8h-on/8h-off schedule; Condition B, 6h-on/6h-off schedule; Conditions C and D represented to different sections of a 4h-on/4h-on call/4h-off/4h-on/4h-on call/4h-off schedule. The Automated Neuropsychological Assessment Metrics (ANAM) was used to assess cognitive function. The tasks included in this analysis were Code Substitution (CDS/CDD), Pursuit Tracking (PUR), Matching to Sample (M2S), and Switching Task (SWT). Stability of performance during waking was compared between the conditions using Kruskal-Wallis tests. Results The analysis of cognitive performance tasks yielded mixed findings. Performance on all tasks was ranked from best to worst: Condition D (>Conditions A, B, C; all p < .05), Condition A (>Conditions B, C; p < .05 and p <.001, respectively), Condition B, Condition C. Regarding stability of higher order cognitive function across the waking day, Condition A exhibited the worst stability, and was the only condition whereby performance degraded across the wake period. Discussion These findings highlight the variability in cognitive capacities during different shiftwork schedules. It is important to examine higher order cognitive function, and other cognitive abilities during shiftwork, when evaluating different shiftwork schedules.

“DINO Vs. DINI” educational game to increase children's cognitive abilities—what are its level elements?

Games designed for children have the potential to serve as educational tools, incorporating learning components that promote engagement and facilitate the child's cognitive and developmental progress, tailored to their specific age group. The significance of Early Childhood Cognitive Abilities is in their association with everyday tasks and functions. The promotion of cognitive development in individuals with AUD necessitates the provision of many opportunities for cognitive stimulation. Children must attain fundamental competencies commensurate with their chronological age in cognitive development. The objective of developing this educational game is to assist early childhood education (PAUD) teachers and parents in delivering instruction through imaginative and inventive simulations. This study employs the Research and Development (R&D) technique, utilizing a 4D model. The instructional game incorporates many level features that assess difficulty, accuracy, memory, and thinking abilities. This educational game encompasses four distinct learning modules tailored for early infant development. These modules include word completion exercises, counting activities, picture guessing tasks, color identification exercises, and competitive elements. The utilization of educational games is anticipated to facilitate the enhancement of children's cognitive capacities, thereby preparing them for the subsequent stages of their primary education.

A Leibniz-Informed Approach to Nietzsche’s Drive Psychology

Abstract Despite drives’ importance for Nietzsche’s explanation of individuals’ values, controversies persist over how to interpret Nietzsche’s attribution of normative capacities to the drives themselves. On one reading, drives evaluate their aims and recognize the normative authority of other drives’ aims. On another, drives’ normative properties reduce to nonnormative, causal properties. Neither approach is satisfying. The former commits Nietzsche to the homuncular fallacy by granting drives complex cognitive capacities. The latter reading either commits Nietzsche to the naturalistic fallacy, having him derive normative conclusions from descriptive premises, or eliminates normativity from his thought altogether. In response to this impasse, this article advances a Leibniz-informed interpretation of Nietzsche’s drive psychology. By construing the normative and efficient causal orders as parallel modes of explanation distinguished by one’s perspective, a Leibniz-informed reading captures the benefits of extant interpretations while avoiding their drawbacks.

The impact of early life stress and schizophrenia on motor and cognitive functioning: an experimental study

BackgroundEarly life stress (ELS) and parental psychopathology, such as schizophrenia (SZ), have been associated with altered neurobiological and behavioral outcomes later in life. Previous studies have investigated the effects of ELS and parental SZ on various aspects of behavior, however, we have studied the combined effects of these stressors and how they interact, as individuals in real-life situations may experience multiple stressors simultaneously.ObjectiveThe aim of this study was to investigate the impact of ELS and schizophrenia on locomotor activity, anxiety-like behavior, exploratory tendencies, and spatial memory in Sprague Dawley (SD) rats.MethodsMale and female SD pups were randomly assigned to eight groups: control, ELS, schizophrenia, and ELS + schizophrenia. ELS was induced by prenatal stress (maternal stress) and maternal separation (MS) during the first 2 weeks of life, while SZ was induced by subcutaneous administration of ketamine. Behavioral tests included an open field test (OFT) for motor abilities and a Morris water maze (MWM) for cognitive abilities. ANOVA and post hoc Tukey tests were utilized to analyze the data.ResultsOur results show that ELS and parental psychopathology had enduring effects on SZ symptoms, particularly psychomotor retardation (p < 0.05). The OFT revealed increased anxiety-like behavior in the ELS group (p = 0.023) and the parental psychopathology group (p = 0.017) compared to controls. The combined ELS and parental psychopathology group exhibited the highest anxiety-like behavior (p = 0.006). The MWM analysis indicated impaired spatial memory in the ELS group (p = 0.012) and the combined ELS and parental psychopathology group (p = 0.003) compared to controls. Significantly, the exposure to ELS resulted in a decrease in the population of glial fibrillary acidic protein-positive (GFAP+) astrocytes. However, this effect was reversed by positive parental mental health.ConclusionOur findings highlight the interactive effects of ELS and parental psychopathology on anxiety-like behavior and spatial memory in rats. ELS was linked to increased anxiety-like behavior, while SZ was associated with anhedonia-like behavior. Positive parenting augments neuroplasticity, synaptic function, and overall cognitive capacities.

Improved Cochlear Implant Performance Estimation Using Tonotopic-Based Electrocochleography

Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating patient prognosis. To assess whether ECochG-total response (ECochG-TR) recorded at the best-frequency electrode (BF-ECochG-TR) correlates more strongly with speech perception performance than ECochG-TR measured at the round window (RW-ECochG-TR). This single-center cross-sectional study recruited 142 patients from July 1, 2021, to April 30, 2022, with 1-year follow-up. Exclusions included perilymph suctioning, crimped sound delivery tubes, non-native English speakers, inner ear malformations, nonpatent external auditory canals, or cochlear implantation revision surgery. Cochlear implantation. Speech perception testing, including the consonant-nucleus-consonant (CNC) words test, AzBio sentences in quiet, and AzBio sentences in noise plus 10-dB signal to noise ratio (with low scores indicating poor performance and high scores indicating excellent performance on all tests), at 6 months postoperatively; and RW-ECochG-TR and BF-ECochG-TR (measured for 250, 500, 1000, and 2000 Hz). A total of 109 of the 142 eligible postlingual adults (mean [SD] age, 68.7 [15.8] years; 67 [61.5%] male) were included in the study. Both BF-ECochG-TR and RW-ECochG-TR were correlated with 6-month CNC scores (BF-ECochG-TR: r = 0.74; 95% CI, 0.62-0.82; RW-ECochG-TR: r = 0.67; 95% CI, 0.54-0.76). A multivariate model incorporating age, duration of hearing loss, and angular insertion depth did not outperform BF-ECochG-TR or RW-ECochG-TR alone. The BF-ECochG-TR correlation with CNC scores was significantly stronger than the RW-ECochG-TR correlation (r difference = -0.18; 95% CI, -0.31 to -0.01; z = -2.02). More moderate correlations existed between 6-month AzBio scores in noise, Montreal Cognitive Assessment (MoCA) scores (r = 0.46; 95% CI, 0.29-0.60), and BF-ECochG-TR (r = 0.42; 95% CI, 0.22-0.58). MoCA and the interaction between BF-ECochG-TR and MoCA accounted for a substantial proportion of variability in AzBio scores in noise at 6 months (R2 = 0.50; 95% CI, 0.36-0.61). In this case series, BF-ECochG-TR was identified as having a stronger correlation with cochlear implantation performance than RW-ECochG-TR, although both measures highlight the critical role of the cochlear-neural substrate on outcomes. Demographic, audiologic, and surgical factors demonstrated weak correlations with cochlear implantation performance, and performance in noise was found to require a robust cochlear-neural substrate (BF-ECochG-TR) as well as sufficient cognitive capacity (MoCA). Future cochlear implantation studies should consider these variables when assessing performance and related interventions.

Gesture production at encoding supports narrative recall

Existing research is inconsistent regarding the effects of gesture production on narrative recall. Most studies have examined the effects of gesture production during a recall phase, not during encoding, and findings regarding gesture’s effects are mixed. The present study examined whether producing gestures at encoding could benefit an individual’s narrative recall and whether this effect is moderated by verbal memory and spatial ability. This study also investigated whether producing certain types of gesture is most beneficial to recalling details of a narrative. Participants read a narrative aloud while producing their own gestures at pre-specified phrases in the narrative (Instructed Gesture condition), while placing both their hands behind their backs (No Gesture condition) or with no specific instructions regarding gesture (Spontaneous Gesture condition). Participants completed measures of spatial ability and verbal memory. Recall was measured through both free recall, and specific recall questions related to particular phrases in the narrative. Spontaneous gesture production at encoding benefited free recall, while instructed gestures provided the greatest benefit for recall of specific phrases where gesture had been prompted during encoding. Conversely, for recall of specific phrases where gesture had not been prompted during encoding, instructions to either gesture or not gesture suppressed recall for those higher in verbal memory. Finally, producing iconic and deictic gestures provided benefits for narrative recall, whilst beat gestures had no effect. Gestures play an important role in how we encode and subsequently recall information, providing an opportunity to support cognitive capacity.