This paper has studied the issue of agitations for self-determination in Nigeria from an African philosophical point of view. It studied these agitations in the light of the amalgamation treaty of 1914, the Constitution of the Federal Republic of Nigeria and most importantly, extant international laws. The beauty of this piece is that it focused on major issues which constitute the basis for the agitations for self-determination in Nigeria namely religious marginalization, ethnic marginalization, economic marginalization and political marginalization. The burden of this piece is the issue of the problem of co-existence in Nigeria. This paper articulated its position based on Igwebuike philosophy as a theoretical framework, which emphasizes dialogue, justice and inclusive leadership as indispensable pathways to integration and national unity. For the purpose of this study, the historical and analytical methods of inquiry were patronized given that historical events were studied and the outcome of such events analysed. It submits that, rather than using force to quell the agitation for self-determination, the path of justice, dialogue and inclusive leadership should be explored as most cases of cessation are responses to the absence of these state ideals.