Wound dressings can be used prophylactically or during actual treatment. Preventative dressings have become a standard of care to prevent pressure ulcers in patients while in bed. While the mechanism of the preventative benefit has not been completely explained, the friction between the dressing and linen is hypothesized as being a key performance factor. The objective of this project was to quantify the static and kinetic coefficients of friction (COF) of various brands of prophylactic dressings under the stresses experienced in situ, while the dressings are in contact with bed linen materials. The COF of six commercial dressings were calculated using tribometer measurements. The ranges of static COF were 0.333-0.542 and kinetic COF were 0.333-0.513. Four dressings exhibited COF that were consistent with skin-linen values reported in the literature and all dressing COF appear to be lower than the COF of moist skin against linen.